Results 61 to 70 of about 48,524 (285)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Effect of drain pipes on seepage and slope stability through a zoned earth dam
Open EngineeringEarth dams must be supplied with seepage control devices to prevent piping and sloughing. One such device used for this purpose is the so-called drain pipe.
Hassan Waqed H. +2 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Analytical determination of seeping soil slopes of a constant exit gradient
, 2020 Soil slopes satisfying the condition of a constant exit gradient (constant Darcian velocity) and the seepage face (isobaricity) condition are found by complex analysis.
Kacimov A., Obnosov Y.
core
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
مجلة النهرين للعلوم الهندسية, 2017 This paper is intended to study the effect of using upstream and downstream sheet pile in double soil layer on the seepage, uplift pressure exit gradient at toe of hydraulic structure using computer program SEEP/W software.
Asmaa Abdul Jabbar Jamel
doaj
Journal of Materials Research and Technology, 2021 The adoption of high ram velocity is beneficial to enhance the production efficiency of the extrusion process, while it can cause an obvious temperature rise, resulting in rapid grain growth and even over-burning.
Liang Chen +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Emittance compensation of compact superconducting guns and booster linac system
Physical Review Special Topics. Accelerators and Beams, 2006 We discuss the mechanics of emittance compensation for a compact superconducting rf gun with a solenoid, a drift space, and a linac system, and give general rules for designing such a system.
Xiangyun Chang +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source