Results 141 to 150 of about 135,933 (245)

Hypertriglyceridemia: Causes, Consequences, Diagnosis, and Management

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Hypertriglyceridemia (HTG) arises from the interplay between genetic susceptibility and secondary or precipitating factors, leading to dysregulated triglyceride‐rich lipoprotein (TRL) metabolism. Increased TRL production and impaired clearance promote distinct risk phenotypes: accumulation of apolipoprotein B(apoB)‐containing TRL remnants contributes ...
Shanshan Qi   +9 more
wiley   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

open access: yesMedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao   +5 more
wiley   +1 more source

Bruton's Tyrosine Kinase Inhibitors: Mechanisms, Efficacy, Toxicities and Applications for the Treatment of Human Diseases

open access: yesMedComm, Volume 7, Issue 10, October 2026.
BTK inhibitors suppress malignant B‐cell signaling while simultaneously reshaping immune regulation through effects on T cells and the tumor microenvironment. These mechanisms support combination immunotherapy strategies and also underlie the expanding application of BTK inhibitors in solid tumors, autoimmune and inflammatory diseases.
Miao Sun, Dengju Li, Jia Wei
wiley   +1 more source

A Systematic Review and Meta‐Analysis of Malnutrition and Metabolic Failure in High‐Potency Incretin Therapy

open access: yesObesity Science &Practice, Volume 12, Issue 5, October 2026.
ABSTRACT Objective High‐potency incretin therapy achieved substantial weight loss, but the extreme energy deficits it induced may obscure the underlying nutritional deterioration. This meta‐analysis synthesized data from 19 randomized trials across the SURMOUNT, STEP, SCALE, and OASIS programs to quantify the nutritional and body composition ...
Eugene Ampofo   +3 more
wiley   +1 more source

Electrolyte and fluid secretion in the exocrine pancreas

open access: yes, 1987
'Electrolyte and Fluid Secretion in the Exocrine Pancreas'. With adequate illustrations the structure of the exocrine pancreas and in vivo and in vitro methods for study of electrolyte and water secretion are presented.
Schulz, I.
core  

Aetiology‐Specific Pancreatic Enzyme Dose Requirements and Treatment Outcomes in Pancreatic Exocrine Insufficiency: The Multicentre EURO‐PEI Registry

open access: yesUnited European Gastroenterology Journal, Volume 14, Issue 8, October 2026.
ABSTRACT Background Pancreatic exocrine insufficiency (PEI) is a maldigestion syndrome leading to symptoms and nutritional deficiencies. Prospective real‐world data on pancreatic enzyme replacement therapy (PERT) dose requirements across aetiologies are limited. Objective To define PERT dose requirements and treatment outcomes across PEI aetiologies in
J. Enrique Domínguez‐Muñoz   +17 more
wiley   +1 more source

Natural History of Recurrent Acute Pancreatitis: Implications for Interventional Trial Design

open access: yesAlimentary Pharmacology &Therapeutics, Volume 64, Issue 7, Page 976-984, October 2026.
In this nationwide cohort of 6894 patients with recurrent acute pancreatitis, recurrence risk increased progressively with each episode and occurred most frequently within the first year. Successive episodes were separated by shorter intervals, indicating an accelerating disease course and highlighting the importance of early preventive interventions ...
Søren S. Olesen   +7 more
wiley   +1 more source

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