Results 281 to 290 of about 153,788 (344)

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

Synaptic Vesicle Recycling at the Developing Presynapse. [PDF]

J Neurochem
Kim N, Cousin MA.
europepmc   +1 more source

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri, Lucia Santorelli, Gabriella De Blasi, Sara Costantini, Eunjoo Jun Lee, Antonio Galeone, Alessia Calcagnì, Marinella Pirozzi, Loretta L. del Mercato, Rossella Venditti, Giovanni D'Angelo, Seetharaman Parashuraman, Tiziano Verri, Giuseppe Gigli, Elizabeth S. Sztul, Paolo Grumati, Loris Rizzello, Domenico Russo, Riccardo Rizzo   +21 more
wiley   +1 more source

The Role of [beta]2-Syntrophin Phosphorylation in Secretory Granule Exocytosis

, 2005
Sandra Schubert
openalex   +1 more source

TMEM131‐Mediated Soluble TRAIL Triggered Type II Alveolar Epithelial Cell Senescence in Radiation‐Induced Lung Injury

Advanced Science, Volume 13, Issue 6, 30 January 2026.
TMEM131 recruits the COPII complex to accelerate TRAIL transportation from endoplasmic reticulum to Golgi apparatus, and promotes soluble TRAIL secretion. TRAIL inhibits mitophagy and induces senescence through DR5 receptor in type II alveolar epithelial cells, ultimately driving radiation‐induced lung injury (RILI) progression.
Linzhi Han, Chunsheng Wang, Xiuli Guo, Yuan Luo, Jianguo Zhang, Fajian He, Zihang Zeng, Jiang Luo, Wen Ouyang, Yan Gong, Conghua Xie   +10 more
wiley   +1 more source

Transport of membranes and vesicle contens during exocytosis [PDF]

, 1980
Bücher, Theodor, Gratzl, Manfred
core  

A novel cause of type 1 von Willebrand disease: impaired exocytosis of Weibel-Palade bodies due to biallelic MADD variants.

Blood
Hordijk S, Groten SA, Bürgisser PE, Laan SNJ, Korenke GC, Honzík T, Beysen D, Leebeek FWG, Skehel PA, van den Biggelaar M, Carter T, Bierings R.   +11 more
europepmc   +1 more source

Highly adaptable deep-learning platform for automated detection and analysis of vesicle exocytosis. [PDF]

Nat Commun
Chouaib AA, Chang HF, Khamis OM, Alawar N, Echeverry S, Demeersseman L, Elizarova S, Daniel JA, Tian Q, Lipp P, Fornasiero EF, Valitutti S, Barg S, Pape C, Shaib AH, Becherer U.   +15 more
europepmc   +1 more source

Perforation of the host cell plasma membrane during Toxoplasma invasion requires rhoptry exocytosis. [PDF]

EMBO Rep
Male F, Kegawa Y, Blank PS, Jiménez-Munguía I, Sidik SM, Valleau D, Lourido S, Lebrun M, Zimmerberg J, Ward GE.   +9 more
europepmc   +1 more source