Results 51 to 60 of about 931,619 (314)

Patterns of Carbon-Bound Exogenous Compounds Impact Disease Pathophysiology in Lung Cancer Subtypes in Different Ways. [PDF]

, 2023
Carbon-bound exogenous compounds, such as polycyclic aromatic hydrocarbons (PAHs), tobacco-specific nitrosamines, aromatic amines, and organohalogens, are known to affect both tumor characteristics and patient outcomes in lung squamous cell carcinoma ...
Kunzke, T., Shen, Jian, Berezowska, Sabina, Wang, Q., Walch, Axel, Kunzke, Thomas, Prade, V.M., Wang, Jun, Wang, J., Sun, N., Buck, Achim, Berezowska, S., Buck, A., Shen, J., Feuchtinger, Annette, Hu, Ronggui, Wang, Qian, Prade, Verena M, Feuchtinger, A., Walch, A., Zens, Philipp, Sun, Na, Zens, P., Hu, R.   +23 more
core   +2 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Argumentation as Exogenous Coordination [PDF]

, 2018
Formal argumentation is one of the most popular approaches in modern logic and reasoning. The theory of abstract argumentation introduced by Dung in 1995 has shifted the focus from the internal structure of arguments to relations among arguments, and temporal dynamics for abstract argumentation was proposed by Barringer, Gabbay and Woods in 2005.
Leendert W. N. van der Torre, Tjitze Rienstra, Dov M. Gabbay   +2 more
openaire   +2 more sources

Epidemiology of Exogenous Estrogens [PDF]

HSMHA Health Reports, 1971
EPIDEMIOLOGY, because of its concern with populations rather than individuals, is able to give unique insights into the etiology and prevention of disease and the influence of man's environment upon his health. The increasingly widespread use in recent years of exogenous estrogenic hormones by relatively healthy women has added a powerful new ...
R E, Markush, S L, Turner
openaire   +2 more sources

Exogenous folates stimulate growth and budding of Candida glabrata

, 2015
Folate, vitamin B9, is well recognized as being essential for cell growth. The utilization of folate is common to all cells, but the source of it may be quite different. For example, mammalian cells depend on exogenous uptake of folates, while
Afsaneh Porzoor, Ian G. Macreadie
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Beyond Plausibly Exogenous [PDF]

SSRN Electronic Journal, 2017
We synthesize two recent advances in the literature on instrumental variable (IV) estimation that test and relax the exclusion restriction. Our approach first estimates the direct effect of the IV on the outcome in a subsample for which the IV does not affect the treatment variable. Subsequently, this estimate for the direct effect is used as input for
van Kippersluis, Hans (J.L.W.), Rietveld, Niels   +1 more
openaire   +3 more sources

Cell-Based Therapies for the Treatment of Traumatic Brain Injury: Promises and Trajectories

Biologics
Traumatic Brain Injury (TBI) is a debilitating condition that poses a significant public health concern. Historically linked to motor vehicle accidents, the epidemiology of TBI has evolved.
Karl J. Habashy, Saad Omais, Benedikt Haupt, Adam M. Sonabend, Christopher S. Ahuja   +4 more
doaj   +1 more source

Attentional routes to conscious perception

Frontiers in Psychology, 2012
The relationships between spatial attention and conscious perception are currently the object of intense debate. Recent evidence of double dissociations between attention and consciousness cast doubt on the time-honored concept of attention as a gateway ...
Ana B Chica, Paolo eBartolomeo
doaj   +1 more source