Results 41 to 50 of about 416,673 (167)

The effectiveness of phosphocreatine cardioprotection during vascular surgery in high cardiac risk patients

Вестник анестезиологии и реаниматологии
The objective was to study the occurrence of perioperative cardiovascular complications (CVС) and clinical and laboratory cardioprotection signs in patients treated with phosphocreatine infusion in intraoperative period of vascular surgery.Materials and ...
I. A. Kozlov, D. A.. Sokolov, P. A. Lyuboshevsky   +2 more
doaj   +1 more source

Creatine supplementation during pregnancy: summary of experimental studies suggestion a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy [PDF]

, 2014
While the use of creatine in human pregnancy is yet to be fully evaluated, its long-term use in healthy adults appears to be safe, and its well documented neuroprotective properties have recently been extended by demonstrations that creatine improves ...
Dickinson, Hayley, Ellery, Stacey, Ireland, Zoe, LaRosa, Domenic, Snow, Rodney, Walker, David W   +5 more
core   +2 more sources

Effectiveness of neoton in patients with heart failure receiving sacubitril/valsartan. Sub-analysis of the BYHEART study

Российский кардиологический журнал
Aim. To study the effectiveness of exogenous phosphocreatine (EP) therapy in patients with heart failure (HF) with reduced and mildly reduced ejection fraction (EF) receiving sacubitril/valsartan.Material and methods.
S. N. Tereshchenko, A. A. Safiullina
doaj   +1 more source

Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia [PDF]

, 2013
The definitive version is available at www3.interscience.wiley.comExercise in hypoxia is associated with reduced muscle oxidative function and impaired exercise tolerance.
Adams, Allen, Amann, Andrew M. Jones, Anni Vanhatalo, Arnold, Bailey, Bailey, Blei, Brown, Bryan, Bulmer, Calbet, Casey, Casey, Cosby, Crecelius, Duncan, Ellis, Erzurum, Govoni, Hagen, Haseler, Haseler, Haseler, Haseler, Heinonen, Heinonen, Hogan, Hogan, James R. Blackwell, Jonathan Fulford, Kapil, Kemp, Kemp, Kemp, Kenjale, Lansley, Lanza, Larsen, Larsen, Larsen, Linnarsson, Lundberg, MacLean, Maher, Millar, Modin, Paganini, Paul G. Winyard, Richardson, Richardson, Sindler, Stephen J. Bailey, Taylor, Thomas, Thompson, van Faassen, Vanhamme, Vanhatalo, Vanhatalo, Victor, Webb, Wilkins, Wilkins, Wilson, Yang, Zhang   +67 more
core   +1 more source

Catecholaminergic polymorphic ventricular tachycardia–linked ryanodine receptor variants exhibit domain‐specific calcium leak and calmodulin affinity properties

The Journal of Physiology, EarlyView.
Abstract figure legend Catecholaminergic polymorphic ventricular tachycardia (CPVT) variants in N terminal (NTD) and central domain (CD) but not pore domain induce a pathological RyR2 conformational shift upon protein kinase A (PKA) phosphorylation, similar to that seen in heart failure (HF), calcium/calmodulin‐dependent protein kinase II (CaMKII ...
Hitoshi Uchinoumi, Xiaoqiong Dong, Ivanita Stefanon, Yi Yang, Eduardo Hertel Ribeiro, Bengt Svensson, Xander H. T. Wehrens, Takeshi Yamamoto, Razvan L. Cornea, Robyn T. Rebbeck, Masafumi Yano, Donald M. Bers   +11 more
wiley   +1 more source

Lactate potentiates NMDA receptor currents via an intracellular redox mechanism targeting GluN2B subunits: implications for synaptic plasticity

The Journal of Physiology, EarlyView.
Abstract figure legend Astrocyte‐derived lactate enhances neuronal NMDA receptor (NMDAR) function and synaptic plasticity through a redox‐ and CaMKII‐dependent mechanism. Lactate enters neurons via monocarboxylate transporters (MCTs) and is oxidized by lactate dehydrogenase (LDH) to pyruvate, generating NADH and increasing the intracellular NADH/NAD ...
Hubert Fiumelli, Gabriel Herrera‐López, Fouad Lemtiri‐Chlieh, Lorène Mottier, John Girgis, Carine Ben‐Adiba, Pascal Jourdain, Nicolò Carrano, Hanan Mahmood, Amanda Ooi, Stefan T. Arold, Monica Di Luca, Fabrizio Gardoni, Pierre J. Magistretti   +13 more
wiley   +1 more source

Osmotic Edema Rapidly Increases Neuronal Excitability Through Activation of NMDA Receptor-Dependent Slow Inward Currents in Juvenile and Adult Hippocampus. [PDF]

, 2015
Cellular edema (cell swelling) is a principal component of numerous brain disorders including ischemia, cortical spreading depression, hyponatremia, and epilepsy.
Binder, Devin K, Davila, David, Fiacco, Todd A, Lauderdale, Kelli, Murphy, Thomas, Tung, Tina   +5 more
core   +3 more sources

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

The Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana, Collin Matsumoto, L. Fernando Santana   +2 more
wiley   +1 more source

Mitochondrial physiology in cardiac muscle of deer mice native to high altitude

The Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude deer mice exhibited evolved changes in mitochondrial energy metabolism and reactive oxygen species (ROS) management that may support cardiac performance under cold hypoxic conditions. High‐altitude mice had increased activity of lactate dehydrogenase (LDH) in the heart, probably enhancing the capacity for lactate ...
Ranim Saleem, Samuel G. Robichaud, Simon G. Lamarre, Graham R. Scott   +3 more
wiley   +1 more source

Muscle carnosine metabolism and β-alanine supplementation in relation to exercise and training [PDF]

, 2010
Carnosine is a dipeptide with a high concentration in mammalian skeletal muscle. It is synthesized by carnosine synthase from the amino acids L-histidine and beta-alanine, of which the latter is the rate-limiting precursor, and degraded by carnosinase ...
Baguet, Audrey, Beeckman, Sam, Derave, Wim, Everaert, Inge   +3 more
core   +2 more sources