In vivo imaging of phosphocreatine with artificial neural networks [PDF]
Nature Communications, 2020 Phosphocreatine plays a vital role in cellular energetic homeostasis, but there are no routine diagnostic tests to noninvasively map the distribution with clinically relevant spatial resolution.
Lin Chen +9 more
doaj +3 more sources
Both Creatine and Its Product Phosphocreatine Reduce Oxidative Stress and Afford Neuroprotection in anIn VitroParkinson’s Model [PDF]
ASN Neuro, 2014 Creatine is the substrate for creatine kinase in the synthesis of phosphocreatine (PCr). This energetic system is endowed of antioxidant and neuroprotective properties and plays a pivotal role in brain energy homeostasis. The purpose of this study was to
Alejandro Romero +2 more
exaly +3 more sources
CARDIOPROTECTIVE EFFECTS OF PHOSPHOCREATINE [PDF]
Вестник анестезиологии и реаниматологии, 2018 Goal of the review: to review theoretical and practical aspects of using exogenous phosphocreatine in the patients with cardio-vascular disorders in various clinical situations, given that phospho-transporting system disorders are the one of pathogenic ...
V. V. Lomivorotov +3 more
doaj +4 more sources
Chemical exchange saturation transfer imaging of phosphocreatine in the muscle [PDF]
Magnetic Resonance in Medicine, 2019 To determine the exchange parameters for the CEST of phosphocreatine (PCrCEST) in phantoms and to characterize PCrCEST in vivo in the muscle at different saturation powers and magnetic fields.
Julius Juhyun Chung +2 more
exaly +3 more sources
Role of the phosphocreatine system on energetic homeostasis in skeletal and cardiac muscles
Einstein (São Paulo), 2014 Adenosine triphosphate is the present energy currency in the body, and is used in various cellular and indispensable processes for the maintenance of cell homeostasis.
Lucas Guimarães-Ferreira
doaj +2 more sources
Cardiac protection with phosphocreatine: a meta-analysis
Interactive CardioVascular and Thoracic Surgery, 2016 Phosphocreatine (PCr) plays an important role in the energy metabolism of the heart and a decrease in its intracellular concentration results in alteration of myocardium energetics and work. We conducted a meta-analysis of all randomized and matched trials that compared PCr with placebo or standard treatment in patients with coronary artery disease or ...
LANDONI, GIOVANNI +6 more
openaire +4 more sources
Fusogenic Liposomes for the Intracellular Delivery of Phosphocreatine
PharmaceuticalsBackground/Objective: Maintaining intracellular adenosine triphosphate (ATP) levels is essential for numerous cellular functions, including energy metabolism, muscle contraction, and nerve impulse transmission.
Okhil K. Nag +2 more
doaj +3 more sources
The metabolites for muscle and osteoclast activity are indicators of femoral neck osteoporosis [PDF]
Scientific ReportsFemoral neck osteoporosis is a critical risk factor for a bedbound state, which significantly decreases overall life expectancy, if a patient falls and suffers a fracture.
Masahiro Kameda +2 more
doaj +2 more sources
Artificial mitochondria ameliorates osteoarthritis through restoring cellular energy metabolism homeostasis [PDF]
Bioactive MaterialsMitochondrial dysfunction under pathological or aging conditions disrupts adenosine triphosphate (ATP) synthesis, exacerbating disease progression by skewing energy metabolism toward catabolism.
Wenqiang Yan +7 more
doaj +2 more sources
Mitochondrial TNAP Controls Thermogenesis by Hydrolysis of Phosphocreatine
Nature, 2021 Adaptive thermogenesis has attracted much attention because of its ability to increase systemic energy expenditure and to counter obesity and diabetes1–3.
Yizhi Sun +16 more
semanticscholar +1 more source