Creatine for the Treatment of Depression
Biomolecules, 2019 Depressed mood, which can occur in the context of major depressive disorder, bipolar disorder, and other conditions, represents a serious threat to public health and wellness.
Brent M. Kious +2 more
doaj +1 more source
DiagnosticsThe natural variation in estrogen secretion throughout the female menstrual cycle impacts various organs, including estrogen receptor (ER)-expressed skeletal muscle.
Jimin Ren +4 more
doaj +1 more source
Effects of reduced-volume of sprint interval training and the time course of physiological and performance adaptations [PDF]
, 2017 This study sought to determine the time course of training adaptations to two different sprint interval training programmes with the same sprint: rest ratio (1:8) but different sprint duration.
Babraj, J., Yamagishi, Takaki
core +2 more sources
Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase δ-extending D-loops. [PDF]
, 2017 Synthesis-dependent strand annealing (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an obligatory non-crossover outcome, thus avoiding the potential for chromosomal rearrangements and loss of heterozygosity.
Ede, Christopher +8 more
core +3 more sources
Nitric oxide regulates skeletal muscle fatigue, fiber type, microtubule organization, and mitochondrial ATP synthesis efficiency through cGMP-dependent mechanisms [PDF]
, 2016 Aim: Skeletal muscle nitric oxide–cyclic guanosine monophosphate (NO-cGMP) pathways are impaired in Duchenne and Becker muscular dystrophy partly because of reduced nNOSμ and soluble guanylate cyclase (GC) activity.
Balke, Jordan E +8 more
core +1 more source
Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized 13C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures. [PDF]
, 2020 Non-invasive assessment of the biological aggressiveness of prostate cancer (PCa) is needed for men with localized disease. Hyperpolarized (HP) 13C magnetic resonance (MR) spectroscopy is a powerful approach to image metabolism, specifically the ...
Ahamed, Fayyaz +12 more
core +1 more source
In vivo imaging of phosphocreatine with artificial neural networks
Nature Communications, 2020 Phosphocreatine plays a vital role in cellular energetic homeostasis, but there are no routine diagnostic tests to noninvasively map the distribution with clinically relevant spatial resolution.
Lin Chen +9 more
doaj +1 more source
Disease Models & Mechanisms, 2021 Mitochondrial diseases are genetic disorders that lead to impaired mitochondrial function, resulting in exercise intolerance and muscle weakness. In patients, muscle fatigue due to defects in mitochondrial oxidative capacities commonly precedes muscle ...
Benjamin Chatel +11 more
doaj +1 more source
Transcription start site scanning and the requirement for ATP during transcription initiation by RNA polymerase II [PDF]
, 2016 Saccharomyces cerevisiae RNA polymerase (Pol) II locates transcription start sites (TSS) at TATA-containing promoters by scanning sequences downstream from the site of preinitiation complex formation, a process that involves the translocation of ...
Fishburn, James +2 more
core +2 more sources
The hydrolysis of phosphocreatine and the origin of urinary creatinine [PDF]
, 1947 Shaffer (1), Myers and Fine (2), and Hahn and Meyer (3) adduced evidence that muscle creatine is the precursor of urinary creatinine. This was questioned by Chanutin and Kinard (4) but was conclusively proved by Bloch, Schoenheimer, and Rittenberg (5, 6)
Borsook, Henry, Dubnoff, Jacob W.
core