Results 41 to 50 of about 31,996 (262)

Effect of exogenous phosphocreatine on the course of acute limb ischemia and reperfusion syndrome after arterial reconstruction in patients with vascular trauma

Медицина неотложных состояний
Background. Acute limb ischemia caused by traumatic arterial injury remains one of the most challenging problems of emergency vascular surgery. Restoration of blood flow may paradoxically provoke ischemia-reperfusion injury leading to limb loss.
O.B. Kutovyi, D.O. Kysilevskyi, S.I. Karpenko, O.V. Sokolov   +3 more
doaj   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

Exploration of human brain tumour metabolism using pairwise metabolite-metabolite correlation analysis (MMCA) of HR-MAS 1H NMR spectra. [PDF]

PLoS ONE, 2017
We quantified 378 HRMAS 1H NMR spectra of human brain tumours (132 glioblastomas, 101 astrocytomas, 75 meningiomas, 37 oligodendrogliomas and 33 metastases) from the eTumour database and looked for metabolic interactions by metabolite-metabolite ...
Basetti Madhu, Alexandra Jauhiainen, Sean McGuire, John R Griffiths   +3 more
doaj   +1 more source

Phosphocreatine in Insulinized Frogs.

Experimental Biology and Medicine, 1929
Fiske and Subbarow1 have isolated phosphocreatine from protein-free muscle filtrates and find “that the compound is destroyed during contraction at a rate which rivals that of glycogenolysis and lactic acid production.” Modern theories of muscle contraction have as their foundation the change of glycogen into lactic acid. But it has been shown that the
J. M. D. Olmsted, H. Mackler
openaire   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Apparent inhibition of pyruvate kinase by phosphocreatine and phosphoarginine

, 1979
Addition of a non-dialysable, heat-labile and acid-precipitable factor which was not absorbed on DEAE-cellulose column, could restore the sensitivity of the chromatographed muscle pyruvate kinase from Marphysa sanguinea towards phosphocreatine inhibition.
Wu, SWN, Wong, SC, Yeung, D
core   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Phosphocreatine and inorganic phosphate kinetics.

, 2013
Time course of phosphocreatine (PCr) and inorganic phosphate (Pi) are shown during exercise in increment 1 and recovery period after maximal exhaustive exercise. Curves are shown as a comparison of healthy controls (dashed curves) to treatment naïve FRDA
Michael Schocke (89558), Rainer Schneider (87432), Julia Wanschitz (439157), Andreas Eigentler (439156), Sylvia Boesch (439155), Werner Poewe (213925), Wolfgang Nachbauer (439154)   +6 more
core   +1 more source

IRES-mediated Pichia pastoris cell-free protein synthesis

Bioresources and Bioprocessing, 2023
Cell-free protein synthesis (CFPS) system is an ideal platform for fast and convenient protein research and has been used for macromolecular assembly, unnatural amino acid embedding, glycoprotein production, and more.
Yanan Wang, Ting Wang, Xinjie Chen, Yuan Lu   +3 more
doaj   +1 more source

Differential response of muscle phosphocreatine to creatine supplementation in young and old subjects

, 2002
This study compared the effects of short-term creatine supplementation on muscle phosphocreatine, blood and urine creatine levels, and urine creatinine levels in elderly and young subjects.
Price, TB, Miles, MP, Price, Thomas B., Clarkson, P. M., Rawson, Eric S., Rawson, E. S., E. S. Rawson, Clarkson, Priscilla M., M. P. Miles, Clarkson, PM, Miles, M. P., T. B. Price, Rawson, ES, Miles, Mary P., P. M. Clarkson, Price, T. B.   +15 more
core   +1 more source