Results 51 to 60 of about 31,996 (262)

Lower Mitochondrial Energy Production of the Thigh Muscles in Patients With Low‐Normal Ankle‐Brachial Index

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundLower muscle mitochondrial energy production may contribute to impaired walking endurance in patients with peripheral arterial disease. A borderline ankle‐brachial index (ABI) of 0.91 to 1.10 is associated with poorer walking endurance compared
Majd AlGhatrif, Ariel Zane, Matt Oberdier, Marco Canepa, Stephanie Studenski, Eleanor Simonsick, Richard G. Spencer, Kenneth Fishbein, David Reiter, Edward G. Lakatta, Mary M. McDermott, Luigi Ferrucci   +11 more
doaj   +1 more source

Myocardial inflammation is associated with impaired mitochondrial oxidative capacity in ischaemic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1246-1255, April 2025.
Abstract Aims Myocardial inflammation and impaired mitochondrial oxidative capacity are hallmarks of heart failure (HF) pathophysiology. The extent of myocardial inflammation in patients suffering from ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and its association with mitochondrial energy metabolism are unknown.
Julius Borger, Elric Zweck, Constanze Moos, Patrick Horn, Fabian Voß, Heinz‐Peter Schultheiss, Jacob Eifer Møller, Udo Boeken, Hug Aubin, Artur Lichtenberg, Malte Kelm, Michael Roden, Amin Polzin, Ralf Westenfeld, Julia Szendroedi, Daniel Scheiber   +15 more
wiley   +1 more source

Mitochondrial DNA depletion by ethidium bromide decreases neuronal mitochondrial creatine kinase: Implications for striatal energy metabolism. [PDF]

PLoS ONE, 2017
Mitochondrial DNA (mtDNA), the discrete genome which encodes subunits of the mitochondrial respiratory chain, is present at highly variable copy numbers across cell types.
Emily Booth Warren, Aidan Edward Aicher, Joshua Patrick Fessel, Christine Konradi   +3 more
doaj   +1 more source

Time constants of phosphocreatine and inorganic phosphate.

, 2013
PCr and Pi time constants (τ) and steady state levels (Δss) for FRDA patients before (FRDA baseline) and after (FRDA rhuEPO) erythropoietin stimulation are shown as comparison to the corresponding control group.
Michael Schocke (89558), Rainer Schneider (87432), Julia Wanschitz (439157), Andreas Eigentler (439156), Sylvia Boesch (439155), Werner Poewe (213925), Wolfgang Nachbauer (439154)   +6 more
core   +1 more source

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

Both Creatine and Its Product Phosphocreatine Reduce Oxidative Stress and Afford Neuroprotection in an Parkinson’s Model

, 2014
Creatine is the substrate for creatine kinase in the synthesis of phosphocreatine (PCr). This energetic system is endowed of antioxidant and neuroprotective properties and plays a pivotal role in brain energy homeostasis. The purpose of this study was to
Rodrigues, Ana Lúcia Severo, Mauricio Peña Cunha, Egea Máiquez, Francisco Javier, Carla I. Tasca, Tasca, Carla I., Marcelo Farina, Alejandro Romero, Javier Egea, Farina, Marcelo, Maria D. Martín-de-Saavedra, García López, Manuela, Manuela G. López, Ana Lúcia S. Rodrigues, Peña Cunha, Mauricio, Fabiana K. Ludka, Ludka, Fabiana K., Martín De Saavedra Álvarez De Uribarri, María Dolores, Romero Montero, Alejandro   +17 more
core   +1 more source

Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score

ESC Heart Failure, Volume 12, Issue 2, Page 1427-1436, April 2025.
Abstract Background and objectives Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis.
Loïc Faucher, Kensuke Matsushita, Shinnosuke Kikuchi, Taraneh Tatarcheh, Benjamin Marchandot, Amandine Granier, Said Amissi, Antonin Trimaille, Laurence Jesel, Patrick Ohlmann, Kiyoshi Hibi, Valérie Schini‐Kerth, Olivier Morel   +12 more
wiley   +1 more source

No effect of creatine supplementation on oxidative stress and cardiovascular parameters in spontaneously hypertensive rats

Journal of the International Society of Sports Nutrition, 2012
Background Exacerbated oxidative stress is thought to be a mediator of arterial hypertension. It has been postulated that creatine (Cr) could act as an antioxidant agent preventing increased oxidative stress.
Alves Christiano RR, Murai Igor H, Ramona Pamella, Nicastro Humberto, Bechara Luiz RG, Lancha Antonio H, Brum Patrícia C, Irigoyen Maria C, Gualano Bruno   +8 more
doaj   +1 more source

Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice.

, 2005
BACKGROUND: Heart failure is associated with deranged cardiac energy metabolism, including reductions of creatine and phosphocreatine. Interventions that increase myocardial high-energy phosphate stores have been proposed as a strategy for treatment of ...
ten Hove, Michiel, Schneider, JE, Sebag-Montefiore, L, Lygate, Craig, Neubauer, Stefan, Wallis, Julie, Zhang, Mei Hua, Fischer, Alexandra, Watkins, Hugh, Watkins, H, Hulbert, K, Schneider, Juergen, Fischer, A, Sebag-Montefiore, Liam, Lygate, CA, Dawson, Dana, Zhang, Wen, Zhang, MH, Zhang, W, Dawson, D, Schneider, Jürgen E., Neubauer, S, Lygate, Craig A., Hulbert, Karen, Clarke, Kieran, Clarke, K, Wallis, J, ten Hove, M   +27 more
core   +1 more source

Epilepsy‐associated SCN2A‐L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids

Epilepsia, EarlyView.
Abstract Objective SCN2A pathogenic mutations, such as the recurrent heterozygous Nav1.2‐L1342P, are monogenic causes of epilepsy. In this human‐induced pluripotent stem cell–derived model system, we aim to investigate the molecular and cellular mechanisms underlying SCN2A‐L1342P‐associated pathology. Methods Using a human male induced pluripotent stem
Maria I. Olivero‐Acosta, Morgan Robinson, Zhefu Que, Zaiyang Zhang, Karen V. Salazar‐Salazar, Hope Elizabeth Harlow, Vinayak Shankar, Seoyeon Hong, Muhan Wang, Conrad M. Otterbacher, Hina Kadono, Manasi Halurkar, Harish Kothandaraman, Nadia Atallah Lanman, Trang Nguyen, Kyle Wettschurack, Benjamin Zirkle, Layan Yunis, Ningren Cui, Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, William C. Skarnes, Chongli Yuan, Feng Guo, Megan Abbott, Yang Yang   +26 more
wiley   +1 more source