Results 51 to 60 of about 44,180 (297)

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

How Does Creatine Supplementation Affect Physical Performance and Muscle Recovery? - A Literature Review of Its Effects, Mechanisms of Action, Safety and Side Effects

Quality in Sport
Introduction: Creatine is a naturally occurring compound that plays a primary role in energy metabolism, particularly within muscle cells. Its main sites of synthesis include the liver, kidneys, and pancreas [1,2].
Martyna Pacanowska, Małgorzata Blecharczyk, Igor Zydlewski, Martyna Mrozek, Alicja Nowik, Marcin Sękulski, Maciej Kosiński, Paweł Jakubiec   +7 more
doaj   +1 more source

Efficacy of a four-week uphill sprint training intervention in field hockey players [PDF]

, 2016
Current evidence increasingly suggests that very short, supra-maximal bouts of exercise can have significant health and performance benefits. The majority of research conducted in the area however, uses laboratory-based protocols, which can lack ...
Babraj, John A., Jakeman, John R., McMullan, Judith   +2 more
core   +3 more sources

Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output

Advanced Science, EarlyView.
Mild cooling of the cortical surface selectively modulates apical dendritic excitability, plasticity, and somato‐dendritic coupling, while uncoupling these effects from basal dendrites, and reshapes apical‐driven responses in barrel cortex during whisker touch.
Meisam Habibi Matin, Shulan Xiao, Krishna Jayant   +2 more
wiley   +1 more source

Abstract 096 | Hidden energy deficiency and therapeutic strategies for its correction

European Journal of Translational Myology
Energy consumption and production in the human body underpin the metabolic processes essential for life. Adenosine triphosphate (ATP) is the universal energy currency for all biochemical metabolic reactions; its synthesis and turnover require a supply ...
Natalia F. Tumanova-Ponomareva
doaj   +1 more source

Phosphocreatine in Insulinized Frogs.

Experimental Biology and Medicine, 1929
Fiske and Subbarow1 have isolated phosphocreatine from protein-free muscle filtrates and find “that the compound is destroyed during contraction at a rate which rivals that of glycogenolysis and lactic acid production.” Modern theories of muscle contraction have as their foundation the change of glycogen into lactic acid. But it has been shown that the
J. M. D. Olmsted, H. Mackler
openaire   +1 more source

Detection of Metabolites by Proton Ex Vivo NMR, in Vivo MR Spectroscopy Peaks and Tissue Content Analysis: Biochemical-Magnetic Resonance Correlation: Preliminary Results [PDF]

, 2009
*Aim*: Metabolite concentrations by in vivo magnetic resonance spectroscopy and ex vivo NMR spectroscopy were compared with excised normal human tissue relaxation times and tissue homogenate contents. *Hypothesis*: Biochemical analysis
Arun Agrawala, Madan Rehani, Rakesh Sharma   +2 more
core   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Comparative Bilateral Measurements of Vastus Lateralis Muscle Oxygen Desaturation Kinetics during 30 S Sprint Cycling Exercise: Effects of Age and Performance

Journal of Functional Morphology and Kinesiology
The study assessed vastus lateralis oxygen desaturation kinetics (SmO2) in 32 male cyclists (16 Seniors, 16 Juniors) during a 30 s sprint, examining effects of age and performance.
Karmen Reinpõld, Indrek Rannama, Kristjan Port   +2 more
doaj   +1 more source

Neuroprotective effects of some creatine derivative compounds

Journal of Biological Research, 2010
Some derivatives more lipophylic than creatine, thus theoretically being capable to better cross the blood-brain barrier, were studied for their neuroprotective effect in mouse hippocampal slices.
L. Perasso, M. Giampieri, M. Mazzei, A. Parodi   +3 more
doaj   +1 more source