Results 21 to 30 of about 31,996 (262)

High-Temporal-Resolution Monitoring of Creatine and Phosphocreatine Dynamics in Skeletal Muscle Using Ultrafast Z-Spectroscopy (UFZ) CEST MRI at 3T. [PDF]

Magn Reson Med
ABSTRACT Purpose To evaluate the feasibility of High‐Temporal‐Resolution (HTR) Ultrafast Z‐spectrum (UFZ) CEST MRI for monitoring the dynamic fluctuations of phosphocreatine (PCr) and creatine (Cr) in human skeletal muscle (SM) at 3 T during and after exercise.
Ju L, Samuel TJ, Schär M, Wang K, Wu Y, Weiss RG, Xu J.   +6 more
europepmc   +2 more sources

A clinical future for the myocardial phosphocreatine/adenosine triphosphate ratio? [PDF]

Journal of Cardiovascular Magnetic Resonance
Adrianus J. Bakermans
doaj   +2 more sources

HUMAN IMMUNE SYSTEM AND PHYSICAL EXERCISE

Медицинская иммунология, 2014
. Physiological and biochemical changes proceeding in muscles during physical loads exert systemic influence upon protein biosynthesis. This process is accelerated in presence of free amino acids, sufficient quantities of hormones, creatine, hydrogen ...
Z. Ch. Musin, S. V. Latukhov
doaj   +1 more source

Effects of Delivering Guanidinoacetic Acid or Its Prodrug to the Neural Tissue: Possible Relevance for Creatine Transporter Deficiency

Brain Sciences, 2022
The creatine precursor guanidinoacetate (GAA) was used as a dietary supplement in humans with no adverse events. Nevertheless, it has been suggested that GAA is epileptogenic or toxic to the nervous system.
Enrico Adriano, Annalisa Salis, Gianluca Damonte, Enrico Millo, Maurizio Balestrino   +4 more
doaj   +1 more source

Phosphocyclocreatine is the dominant form of cyclocreatine in control and creatine transporter deficiency patient fibroblasts

Pharmacology Research & Perspectives, 2019
Creatine transporter deficiency (CTD) is a metabolic disorder resulting in cognitive, motor, and behavioral deficits. Cyclocreatine (cCr), a creatine analog, has been explored as a therapeutic strategy for the treatment of CTD.
Kirill Gorshkov, Amy Q. Wang, Wei Sun, Ethan Fisher, Marta Frigeni, Marc Singleton, Natasha Thorne, Bradley Class, Wenwei Huang, Nicola Longo, Minh‐Ha T. Do, Elizabeth A. Ottinger, Xin Xu, Wei Zheng   +13 more
doaj   +1 more source

Creatine for the Treatment of Depression

Biomolecules, 2019
Depressed mood, which can occur in the context of major depressive disorder, bipolar disorder, and other conditions, represents a serious threat to public health and wellness.
Brent M. Kious, Douglas G. Kondo, Perry F. Renshaw   +2 more
doaj   +1 more source

Enzymatic Estimation of Phosphocreatine.

Experimental Biology and Medicine, 1962
SummaryAn enzymatic micro-method has been described which permits simultaneous determination of adenosine triphosphate and phosphocreatine in extracts corresponding to 2-5 mg of muscle. The method has been found to be essentially in agreement with the colorimetric method of Fiske and Subbarow. Phosphocreatine in tissues containing more than 2% glycogen
E N, FAWAZ, G, FAWAZ, K, VON DAHL
openaire   +2 more sources

Toward Cell‐Specific Molecular MRI: Modulating Chemical Exchange Saturation Transfer Contrast With Manganese

Angewandte Chemie, EarlyView.
Manganese‐modulated chemical exchange saturation transfer (CEST) MRI, Manga CEST, leverages intracellular Mn2+ uptake to selectively perturb CEST contrast. Comparing Z‐spectra before and after Mn reveals compartment‐specific contributions. In vivo, neuron‐enriched Mn accumulation induces frequency‐dependent attenuation (3–4 ppm), enabling cell‐weighted
Eleonora Cavallari, Valeria Bitonto, Morgana Giachello, Angelo Bifone   +3 more
wiley   +2 more sources

17β-Estradiol Effects in Skeletal Muscle: A ³¹P MR Spectroscopic Imaging (MRSI) Study of Young Females during Early Follicular (EF) and Peri-Ovulation (PO) Phases

Diagnostics
The natural variation in estrogen secretion throughout the female menstrual cycle impacts various organs, including estrogen receptor (ER)-expressed skeletal muscle.
Jimin Ren, Luis Rodriguez, Talon Johnson, Anke Henning, Yasin Y. Dhaher   +4 more
doaj   +1 more source

Impaired aerobic capacity and premature fatigue preceding muscle weakness in the skeletal muscle Tfam-knockout mouse model

Disease Models & Mechanisms, 2021
Mitochondrial diseases are genetic disorders that lead to impaired mitochondrial function, resulting in exercise intolerance and muscle weakness. In patients, muscle fatigue due to defects in mitochondrial oxidative capacities commonly precedes muscle ...
Benjamin Chatel, Sylvie Ducreux, Zeina Harhous, Nadia Bendridi, Isabelle Varlet, Augustin C. Ogier, Monique Bernard, Julien Gondin, Jennifer Rieusset, Håkan Westerblad, David Bendahan, Charlotte Gineste   +11 more
doaj   +1 more source