Experimental Physiology, Volume 111, Issue 2, Page 474-488, 1 February 2026.Abstract Heart failure (HF) with a mildly reduced ejection fraction (HFmrEF; 40%–49%) is present in ≤25% of HF patients. Therapeutic treatment options for HFmrEF‐associated exercise intolerance are limited. Nitric oxide (NO)‐independent stimulation of soluble guanylyl cyclase to improve peripheral vasodilatation offers a novel approach to enhance ...
Ramona E. Weber +10 more
wiley +1 more source
Noninvasive imaging of receptor function: signal transduction pathways and physiological readouts [PDF]
, 2008 Intracellular signaling describes the process of information propagation from the cell surface to the location within the cell where a biological response is executed. Signaling pathways involve a complex network of interacting molecular species.
Rudin, M
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The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]
, 2013 Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Alex Dyson +23 more
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L-citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans [PDF]
, 2017 This is the author accepted manuscript. The final version is available from the American Physiological Society via the DOI in this record.The purpose of this study was to compare the effects of L-citrulline (CIT) and L-arginine (ARG) supplementation on ...
Bailey, Stephen J. +5 more
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Determinants of curvature constant (W’) of the power duration relationship under normoxia and hypoxia: the effect of pre-exercise alkalosis [PDF]
, 2017 Purpose This study investigated the effect of induced alkalosis on the curvature constant (W’) of the power-duration relationship under normoxic and hypoxic conditions.
Deb, S. +7 more
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Expressing creatine kinase in transgenic tobacco - a first step towards introducing an energy buffering system in plants [PDF]
, 2018 Creatine kinase a key enzyme in cellular energy homeostasis of vertebrates offers the promise of engineering plants with enhanced stress tolerance. In order to provide plants with such an energy buffering system, tobacco was transformed with a cDNA ...
Bailey, James +5 more
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Optimization of ClpXP activity and protein synthesis in an E. coli extract-based cell-free expression system. [PDF]
, 2018 Protein degradation is a fundamental process in all living cells and is essential to remove both damaged proteins and intact proteins that are no longer needed by the cell.
Joseph, Simpson +4 more
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, 2006 Objective. To compare the molecular, histological, and functional characteristics of growth hormone (GH)- and pressure overload-induced cardiac hypertrophy, and their responses to ischemia-reperfusion and mechanical stretch. Design.
A. CITTADINI +12 more
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The role of oxidative, inflammatory and neuroendocrinological systems during exercise stress in athletes [PDF]
, 2012 University of Technology, Sydney. Faculty of Nursing, Midwifery and Health.Introduction: Exercise induces a stress reaction that initiates adaptive processes, which can be modified by intensive physical training and / or exogenous antioxidant ...
Slattery, KM
core
A tight coupling between β\u3csub\u3e2\u3c/sub\u3eY97 and β\u3csub\u3e2\u3c/sub\u3eF200 of the GABA\u3csub\u3eA\u3c/sub\u3e receptor mediates GABA binding [PDF]
, 2011 The GABAA receptor is an oligopentameric chloride channel that is activated via conformation changes induced upon the binding of the endogenous ligand, GABA, to the extracellular inter-subunit interfaces. Although dozens of amino acid residues at the α/β
Laha, Kurt T. +2 more
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