Results 11 to 20 of about 838,049 (387)

Exon Skipping Is Correlated with Exon Circularization

Journal of Molecular Biology, 2015
Circular RNAs are found in a wide range of organisms and it has been proposed that they perform disparate functions. However, how RNA circularization is connected to alternative splicing remains largely unexplored. Here, we stimulated primary human endothelial cells with tumor necrosis factor α or tumor growth factor β, purified RNA, generated >2.4 ...
Kelly, S, Greenman, C, Cook, PR, Papantonis, A   +3 more
openaire   +5 more sources

TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A

Nature, 2021
A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein TDP-43 from the nucleus of neurons in the brain and spinal cord1.
X. R. Ma, M. Prudencio, Y. Koike, Sarat C. Vatsavayai, Garam Kim, Fred Harbinski, Adam Briner, Caitlin M. Rodriguez, Caiwei Guo, T. Akiyama, H. B. Schmidt, Beryl B. Cummings, David W. Wyatt, K. Kurylo, Georgiana Miller, S. Mekhoubad, Nathan A. Sallee, Gemechu Mekonnen, Laura R. Ganser, Jack D. Rubien, Karen R. Jansen-West, C. Cook, Sarah R Pickles, Björn E. Oskarsson, N. Graff-Radford, B. Boeve, D. Knopman, R. Petersen, D. Dickson, J. Shorter, Sua Myong, Eric M. Green, W. Seeley, L. Petrucelli, A. Gitler   +34 more
semanticscholar   +1 more source

Exon architecture controls mRNA m6A suppression and gene expression

Science, 2023
N6-methyladenosine (m6A) is the most abundant messenger RNA (mRNA) modification and plays crucial roles in diverse physiological processes. Using a massively parallel assay for m6A (MPm6A), we discover that m6A specificity is globally regulated by ...
P. He, Jiangbo Wei, Xiaoyang Dou, Bryan T. Harada, Zijie Zhang, Ruiqi Ge, Chang Liu, Li-Sheng Zhang, Xianbin Yu, Shuai Wang, Ruitu Lyu, Zhongyu Zou, Mengjie Chen, C. He   +13 more
semanticscholar   +1 more source

Exon junction complex shapes the m6A epitranscriptome

Nature Communications, 2022
N6-methyladenosine (m^6A), the most abundant modification of mRNA, is essential for normal development and dysregulation promotes cancer. m^6A is highly enriched in the 3’ untranslated region (UTR) of a large subset of mRNAs to influence mRNA stability ...
Xin Yang, Robinson Triboulet, Qi Liu, Erdem Sendinc, R. Gregory   +4 more
semanticscholar   +1 more source

Capmatinib in MET Exon 14-Mutated or MET-Amplified Non-Small-Cell Lung Cancer.

New England Journal of Medicine, 2020
BACKGROUND Among patients with non-small-cell lung cancer (NSCLC), MET exon 14 skipping mutations occur in 3 to 4% and MET amplifications occur in 1 to 6%.
J. Wolf, T. Seto, Ji-Youn Han, N. Reguart, E. Garon, H. Groen, D. Tan, T. Hida, M. D. de Jonge, S. Orlov, E. Smit, P. Souquet, J. Vansteenkiste, M. Hochmair, E. Felip, M. Nishio, Michael Thomas, K. Ohashi, R. Toyozawa, T. Overbeck, F. de Marinis, Tae-Min Kim, E. Laack, A. Robeva, S. Le Mouhaer, M. Waldron-Lynch, B. Sankaran, O. A. Balbin, Xiaoming Cui, M. Giovannini, M. Akimov, R. Heist   +31 more
semanticscholar   +1 more source

Tepotinib in Non-Small-Cell Lung Cancer with MET Exon 14 Skipping Mutations.

New England Journal of Medicine, 2020
BACKGROUND A splice-site mutation that results in a loss of transcription of exon 14 in the oncogenic driver MET occurs in 3 to 4% of patients with non-small-cell lung cancer (NSCLC).
P. Paik, E. Felip, R. Veillon, H. Sakai, A. Cortot, M. Garassino, J. Mazières, S. Viteri, H. Sénellart, J. V. van Meerbeeck, J. Raskin, N. Reinmuth, PierFranco Conte, D. Kowalski, B. Cho, J. Patel, L. Horn, F. Griesinger, Ji-Youn Han, Young-chul Kim, G. Chang, Chen-Liang Tsai, Jie Yang, Yuh-Min Chen, E. Smit, A. J. van der Wekken, T. Kato, D. Juraeva, C. Stroh, R. Bruns, J. Straub, A. Johne, J. Scheele, J. Heymach, X. Le   +34 more
semanticscholar   +1 more source

Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN

bioRxiv, 2021
High-fidelity replication of the large RNA genome of coronaviruses (CoVs) is mediated by a 3′-to-5′ exoribonuclease (ExoN) in non-structural protein 14 (nsp14), which excises nucleotides including antiviral drugs mis-incorporated by the low-fidelity ...
N. H. Moeller, Ke Shi, Özlem Demir, C. Belica, Surajit Banerjee, Lulu Yin, Cameron Durfee, Rommie E. Amaro, H. Aihara   +8 more
semanticscholar   +1 more source

EXFI: Exon and splice graph prediction without a reference genome

Ecology and Evolution, 2020
For population genetic studies in nonmodel organisms, it is important to use every single source of genomic information. This paper presents EXFI, a Python pipeline that predicts the splice graph and exon sequences using an assembled transcriptome and ...
Jorge Langa, Andone Estonba, Darrell Conklin   +2 more
doaj   +1 more source

Alternative Splicing of Putative Stroke/Vascular Risk Factor Genes Expressed in Blood Following Ischemic Stroke Is Sexually Dimorphic and Cause-Specific

Frontiers in Neurology, 2020
Genome-wide association studies have identified putative ischemic stroke risk genes, yet, their expression after stroke is unexplored in spite of growing interest in elucidating their specific role and identifying candidate genes for stroke treatment ...
Cheryl Dykstra-Aiello, Frank R. Sharp, Glen C. Jickling, Heather Hull, Farah Hamade, Natasha Shroff, Marc Durocher, Xiyuan Cheng, Xinhua Zhan, DaZhi Liu, Bradley P. Ander, Boryana S. Stamova   +11 more
doaj   +1 more source

Prevalent use and evolution of exonic regulatory sequences in the human genome

Natural Sciences, 2023
It has long been known that exons can serve as cis‐regulatory sequences, such as enhancers. However, the prevalence of such dual‐use of exons and how they evolve remain elusive.
Jing Chen, Pengyu Ni, Siwen Wu, Meng Niu, Jun‐tao Guo, Zhengsheng Su   +5 more
doaj   +1 more source