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Alternative splicing: Human disease and quantitative analysis from high-throughput sequencing
Computational and Structural Biotechnology Journal, 2021 Alternative splicing contributes to the majority of protein diversity in higher eukaryotes by allowing one gene to generate multiple distinct protein isoforms. It adds another regulation layer of gene expression.
Wei Jiang, Liang Chen
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Pervasive non-triplet alternative splicing drives functional isoform diversity [PDF]
Nature CommunicationsAlternative mRNA splicing is an important mechanism for regulating gene expression and generating transcriptomic diversity. Most cases of alternative splicing studied to date are triplet, meaning that both isoforms retain the same translational reading ...
Shameerudeen Athavudeen +2 more
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The importance of alternative splicing in adaptive evolution [PDF]
Molecular Ecology, 2022 Although alternative splicing is a ubiquitous co-transcriptional gene regulatory mechanism in plants, animals and fungi, its contribution to evolutionary transitions is understudied. Alternative splicing enables different mRNA isoforms to be generated
Pooja Singh +3 more
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Alternative splicing as a regulator of development and tissue identity
Nature Reviews Molecular Cell Biology, 2017 Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate vast protein diversity from a limited number of genes.
FRANCISCO E Baralle +2 more
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Alternative splicing and protein diversity: plants versus animals [PDF]
Frontiers in Plant Science, 2019 Plants, unlike animals, exhibit a very high degree of plasticity in their growth and development and employ diverse strategies to cope with the variations during diurnal cycles and stressful conditions.
Khokhar, W. +6 more
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Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients
Cancer Cell, 2018 SUMMARY Our comprehensive analysis of alternative splicing across 32 The Cancer Genome Atlas cancer types from 8,705 patients detects alternative splicing events and tumor variants by reanalyzing RNA and whole-exome sequencing data. Tumors have up to 30%
André Kahles +2 more
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Alternative Splicing Regulatory Networks: Functions, Mechanisms, and Evolution
Molecular Cell, 2019 High-throughput sequencing-based methods and their applications in the study of transcriptomes have revolutionized our understanding of alternative splicing.
Jernej Ule, Benjamin J Blencowe
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Alternative splicing across the tree of life [PDF]
eLifeThere is a growing understanding of how alternative splicing contributes to functional specialization and adaptation, especially in well-studied model organisms. However, its large-scale evolutionary dynamics remain poorly understood.
Rebeca de la Fuente +3 more
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A New Twist to Ibuprofen: Alternative Action in Alternative Splicing [PDF]
European Medical Journal, 2019 Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) and is a widely used medication. One indication of NSAID use is long-term chemoprevention to decrease the risk of developing various types of cancer, in particular colorectal cancer.
Peter Jordan +2 more
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Alternative Splicing Control of Abiotic Stress Responses [PDF]
Trends in Plant Science, 2018 The deposited article is a post-print version and has been submitted to peer review.This publication hasn't any creative commons license associated.This deposit is composed by the main article, and it hasn't any supplementary materials associated.There ...
Guiomar Martín +5 more
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