The implications of alternative pre-mRNA splicing in cell signal transduction
Experimental and Molecular Medicine, 2023 Cells produce multiple mRNAs through alternative splicing, which ensures proteome diversity. Because most human genes undergo alternative splicing, key components of signal transduction pathways are no exception.
Sunkyung Choi, Namjoon Cho, Kee K. Kim
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Positional proteomics reveals differences in N-terminal proteoform stability [PDF]
, 2016 To understand the impact of alternative translation initiation on a proteome, we performed a proteome-wide study on protein turnover using positional proteomics and ribosome profiling to distinguish between N-terminal proteoforms of individual genes.
Brown JL +4 more
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Betacoronavirus-specific alternate splicing [PDF]
Genomics, 2021 AbstractViruses can subvert a number of cellular processes in order to block innate antiviral responses, and many viruses interact with cellular splicing machinery. SARS-CoV-2 infection was shown to suppress global mRNA splicing, and at least 10 SARS-CoV-2 proteins bind specifically to one or more human RNAs.
Guy Karlebach +13 more
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Alternative Splicing in Neurogenesis and Brain Development
Frontiers in Molecular Biosciences, 2018 Alternative splicing of precursor mRNA is an important mechanism that increases transcriptomic and proteomic diversity and also post-transcriptionally regulates mRNA levels.
Chun-Hao Su +4 more
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Alternative promoters influence alternative splicing at the genomic level. [PDF]
PLoS ONE, 2008 BACKGROUND: More and more experiments have shown that transcription and mRNA processing are not two independent events but are tightly coupled to each other. Both promoter and transcription rate were found to influence alternative splicing.
Dedong Xin, Landian Hu, Xiangyin Kong
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The Perils of Navigating Activity-Dependent Alternative Splicing of Neurexins
Frontiers in Molecular Neuroscience, 2021 Neurexins are presynaptic cell-adhesion molecules essential for synaptic function that are expressed in thousands of alternatively spliced isoforms. Recent studies suggested that alternative splicing at splice site 4 (SS4) of Nrxn1 is tightly regulated ...
Kif Liakath-Ali +3 more
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FreePSI: an alignment-free approach to estimating exon-inclusion ratios without a reference transcriptome. [PDF]
, 2017 Alternative splicing plays an important role in many cellular processes of eukaryotic organisms. The exon-inclusion ratio, also known as percent spliced in, is often regarded as one of the most effective measures of alternative splicing events.
Jiang, Tao +4 more
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An exonic splicing enhancer in human IGF-I pre-mRNA mediates recognition of alternative exon 5 by the serine-arginine protein splicing factor-2/alternative splicing factor [PDF]
, 2002 The human IGF-I gene has six exons, four of which are alternatively spliced. Variations in splicing involving exon 5 may occur, depending on the tissue type and hormonal environment.
Chew, S. L. +6 more
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Alternative Splicing: Emerging Roles in Anti-Aging Strategies
BiomoleculesAlternative splicing plays a fundamental role in gene expression and protein complexity. Aberrant splicing impairs cell homeostasis and is closely associated with aging and cellular senescence.
Lingyue Gao, Rong Jia
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Alternative Splicing in Apicomplexan Parasites
mBio, 2019 Alternative splicing is a widespread, essential, and complex component of gene regulation. Apicomplexan parasites have long been recognized to produce alternatively spliced transcripts for some genes and can produce multiple protein products that are ...
Lee M. Yeoh +3 more
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