Results 51 to 60 of about 3,932,181 (346)

Hypoxia-induced alternative splicing: the 11th Hallmark of Cancer

Journal of experimental & clinical cancer research : CR, 2020
Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and progression. In this review, we update currents concepts of hypoxia-induced alternative splicing and how it influences tumour biology.
A. Farina, L. Cappabianca, Michela Sebastiano, Veronica Zelli, S. Guadagni, A. Mackay   +5 more
semanticscholar   +1 more source

Alternative splicing and related RNA binding proteins in human health and disease

Signal Transduction and Targeted Therapy
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation, engendering transcript diversity, and modifications in protein structure and functionality. Across varying tissues, developmental stages, or under specific conditions,
Y. Tao, Qi Zhang, Haoyu Wang, Xiyu Yang, Haoran Mu   +4 more
semanticscholar   +1 more source

Pharmacology of Modulators of Alternative Splicing [PDF]

Pharmacological Reviews, 2017
More than 95% of genes in the human genome are alternatively spliced to form multiple transcripts, often encoding proteins with differing or opposing function. The control of alternative splicing is now being elucidated, and with this comes the opportunity to develop modulators of alternative splicing that can control cellular function.
Bates, DO, Morris, JC, Oltean, S, Donaldson, LF, Garland, CJ   +4 more
openaire   +4 more sources

Alternative Splicing in Neurogenesis and Brain Development

Frontiers in Molecular Biosciences, 2018
Alternative splicing of precursor mRNA is an important mechanism that increases transcriptomic and proteomic diversity and also post-transcriptionally regulates mRNA levels.
Chun-Hao Su, Dhananjaya D, Dhananjaya D, Woan-Yuh Tarn, Woan-Yuh Tarn   +4 more
doaj   +1 more source

Alternative promoters influence alternative splicing at the genomic level. [PDF]

PLoS ONE, 2008
BACKGROUND: More and more experiments have shown that transcription and mRNA processing are not two independent events but are tightly coupled to each other. Both promoter and transcription rate were found to influence alternative splicing.
Dedong Xin, Landian Hu, Xiangyin Kong
doaj   +1 more source

The Perils of Navigating Activity-Dependent Alternative Splicing of Neurexins

Frontiers in Molecular Neuroscience, 2021
Neurexins are presynaptic cell-adhesion molecules essential for synaptic function that are expressed in thousands of alternatively spliced isoforms. Recent studies suggested that alternative splicing at splice site 4 (SS4) of Nrxn1 is tightly regulated ...
Kif Liakath-Ali, Kif Liakath-Ali, Thomas C. Südhof, Thomas C. Südhof   +3 more
doaj   +1 more source

Quantification of pre-mRNA escape rate and synergy in splicing [PDF]

, 2014
Splicing reactions generally combine high speed with accuracy. However, some of the pre-mRNAs escape the nucleus with a retained intron. Intron retention can control gene expression and increase proteome diversity.
Becskei, Attila, Bonde, M. (M) M. (M), Becskei, A. (A), Baudrimont, A. (A), Séraphin, B. (Bertrand), Mi Bonde, Marie, Voegeli, Sylvia, Bonde, Marie Mi, Baudrimont, Antoine, Voegeli, S. (S), Séraphin, Bertrand, Voegeli, S, Baudrimont, A, Becskei, A   +13 more
core   +1 more source

Editorial on alternative splicing and disease [PDF]

RNA Biology, 2010
(2010). Editorial on alternative splicing and disease. RNA Biology: Vol. 7, No. 4, pp. 388-389.
Barta Andrea, Schuemperli Daniel
openaire   +4 more sources

Alternative Splicing in Apicomplexan Parasites

mBio, 2019
Alternative splicing is a widespread, essential, and complex component of gene regulation. Apicomplexan parasites have long been recognized to produce alternatively spliced transcripts for some genes and can produce multiple protein products that are ...
Lee M. Yeoh, V. Vern Lee, Geoffrey I. McFadden, Stuart A. Ralph   +3 more
doaj   +1 more source

Complex Alternative Splicing [PDF]

, 2007
Alternative splicing is a powerful means of controlling gene expression and increasing protein diversity. Most genes express a limited number of mRNA isoforms, but there are several examples of genes that use alternative splicing to generate hundreds, thousands and even tens of thousands of isoforms.
Jung Woo, Park, Brenton R, Graveley
openaire   +2 more sources