Results 51 to 60 of about 325,117 (198)

rMAPS: RNA map analysis and plotting server for alternative exon regulation. [PDF]

, 2016
RNA-binding proteins (RBPs) play a critical role in the regulation of alternative splicing (AS), a prevalent mechanism for generating transcriptomic and proteomic diversity in eukaryotic cells.
Jung, Sungbo, Park, Juw Won, Rouchka, Eric C, Tseng, Yu-Ting, Xing, Yi   +4 more
core   +2 more sources

Alternative Splicing in CKD [PDF]

Journal of the American Society of Nephrology, 2016
Alternative splicing (AS) has emerged in the postgenomic era as one of the main drivers of proteome diversity, with ≥94% of multiexon genes alternatively spliced in humans. AS is therefore one of the main control mechanisms for cell phenotype, and is a process deregulated in disease.
Stevens, Megan, Oltean, Sebastian
openaire   +3 more sources

Pharmacology of modulators of alternative splicing [PDF]

, 2016
More than 95% of genes in the human genome are alternatively spliced to form multiple transcripts, often encoding proteins with differing or opposing function.
Bates, DO, Donaldson, LF, Garland, CJ, Morris, JC, Oltean, S   +4 more
core   +4 more sources

Alternative splicing: global insights [PDF]

The FEBS Journal, 2010
Following the original reports of pre‐mRNA splicing in 1977, it was quickly realized that splicing together of different combinations of splice sites – alternative splicing– allows individual genes to generate more than one mRNA isoform. The full extent of alternative splicing only began to be revealed once large‐scale genome and transcriptome ...
Hallegger, M, Llorian, M, Smith, C
openaire   +2 more sources

Alternative splicing across the C. elegans nervous system

Nature Communications
Alternative splicing is a key mechanism that shapes transcriptomes, helping to define neuronal identity and modulate function. Here, we present an atlas of alternative splicing across the nervous system of Caenorhabditis elegans.
Alexis Weinreb, Erdem Varol, Alec Barrett, Rebecca M. McWhirter, Seth R. Taylor, Isabel Courtney, Manasa Basavaraju, Abigail Poff, John A. Tipps, Becca Collings, The CeNGEN Consortium, Smita Krishnaswamy, David M. Miller, Marc Hammarlund   +13 more
doaj   +1 more source

Alternative Splicing for Diseases, Cancers, Drugs, and Databases

The Scientific World Journal, 2013
Alternative splicing is a major diversification mechanism in the human transcriptome and proteome. Several diseases, including cancers, have been associated with dysregulation of alternative splicing.
Jen-Yang Tang, Jin-Ching Lee, Ming-Feng Hou, Chun-Lin Wang, Chien-Chi Chen, Hurng-Wern Huang, Hsueh-Wei Chang   +6 more
doaj   +1 more source

DeepASmRNA: Reference-free prediction of alternative splicing events with a scalable and interpretable deep learning model

iScience, 2022
Summary: Alternative splicing is crucial for a wide range of biological processes. However, limited by the availability of reference genomes, genome-wide patterns of alternative splicing remain unknown in most nonmodel organisms.
Lei Cao, Quanbao Zhang, Hongtao Song, Kui Lin, Erli Pang   +4 more
doaj   +1 more source

Interplay between estrogen receptor and AKT in estradiol-induced alternative splicing. [PDF]

, 2013
BACKGROUND: Alternative splicing is critical for generating complex proteomes in response to extracellular signals. Nuclear receptors including estrogen receptor alpha (ERα) and their ligands promote alternative splicing.
A Busch, A Keith Dunker, A Lapuk, AB Moffa, AB Moffa, AC Pond, AJ Matlin, Bert W O’Malley, C Schwerk, C Shin, CE Chalfant, CJ David, CY Lin, D Auboeuf, D Auboeuf, D Auboeuf, D Bittencourt, DC Koboldt, DF Easton, DH Dowhan, DJ Hunter, DJ Jung, EA Musgrove, EM Haugsten, ET Wang, Eun-Kyung Song, H Itoh, H Lee, Harikrishna Nakshatri, Jason S Carroll, JF Caceres, JP Venables, JP Venables, JS Carroll, JY Cha, K Yoshida, KJ Park, L Chen, M Blaustein, M Chen, M Fan, M Gabut, M Pritsker, M Raponi, M Tawara, MJ Ellis, MJ Fullwood, MJ Moore, MMC Lupien, Myles Brown, Nikail R Collins, P Bhat-Nakshatri, P Bhat-Nakshatri, Poornima Bhat-Nakshatri, PR Romero, RA Campbell, RF Luco, S Ali, S Kato, S Salahshor, S Whitman, SA Krum, SA Ochsner, SK Rayala, SR Datta, T Nakamura, Tim R Geistlinger, Vladimir N Uversky, WJ Welboren, X He, Y Masuhiro   +70 more
core   +3 more sources

Alternative splicing and disease [PDF]

RNA Biology, 2008
Splicing is a molecular mechanism, by which introns are removed from an mRNA precursor and exons are ligated to form a mature mRNA. Mutations that cause defects in the splicing mechanism are known to be responsible for many diseases, including cystic fibrosis and familial dysautonomia.
Eddo, Kim, Amir, Goren, Gil, Ast
openaire   +2 more sources

The Bromodomain Protein 4 Contributes to the Regulation of Alternative Splicing

Cell Reports, 2019
Summary: The bromodomain protein 4 (BRD4) is an atypical kinase and histone acetyl transferase (HAT) that binds to acetylated histones and contributes to chromatin remodeling and early transcriptional elongation.
Sheetal Uppal, Anne Gegonne, Qingrong Chen, Petria S. Thompson, Dan Cheng, Jie Mu, Daoud Meerzaman, Hari S. Misra, Dinah S. Singer   +8 more
doaj   +1 more source