Results 61 to 70 of about 325,117 (198)
Computational and Structural Biotechnology Journal, 2020 Alternative splicing of RNAs generates isoform diversity, resulting in different proteins that are necessary for maintaining cellular function and identity.
Wei Xiong Wen +2 more
doaj +1 more source
Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans [PDF]
, 2017 This is the final version of the article. Available from the publisher via the DOI in this record.Dysregulation of splicing factor expression and altered alternative splicing are associated with aging in humans and other species, and also with ...
Emond, F +10 more
core +1 more source
Striking circadian neuron diversity and cycling of Drosophila alternative splicing. [PDF]
, 2018 Although alternative pre-mRNA splicing (AS) significantly diversifies the neuronal proteome, the extent of AS is still unknown due in part to the large number of diverse cell types in the brain.
Abruzzi, Katharine C +3 more
core +2 more sources
Exploration of alternative splicing events in ten different grapevine cultivars [PDF]
, 2015 Background: The complex dynamics of gene regulation in plants are still far from being fully understood. Among many factors involved, alternative splicing (AS) in particular is one of the least well documented.
Asquini, Elisa +8 more
core +7 more sources
eLife, 2020 Cell-specific alternative splicing modulates myriad cell functions and is disrupted in disease. The mechanisms governing alternative splicing are known for relatively few genes and typically focus on RNA splicing factors.
Eduardo Javier López Soto +1 more
doaj +1 more source
Molecular Characterization of Pediatric Restrictive Cardiomyopathy from Integrative Genomics [PDF]
, 2017 Pediatric restrictive cardiomyopathy (RCM) is a genetically heterogeneous heart disease with limited therapeutic options. RCM cases are largely idiopathic; however, even within families with a known genetic cause for cardiomyopathy, there is striking ...
Hinton, Robert B. +3 more
core +1 more source
Therapeutic potential of alternative splicing in cardiovascular diseases
EBioMedicineSummary: RNA splicing is an important RNA processing step required by multiexon protein-coding mRNAs and some noncoding RNAs. Precise RNA splicing is required for maintaining gene and cell function; however, mis-spliced RNA transcripts can lead to loss ...
Jun Cao, Ziyu Wei, Yu Nie, Hou-Zao Chen
doaj +1 more source
Crosstalk between m6A modification and alternative splicing during cancer progression
Clinical and Translational Medicine, 2023 Background N6‐methyladenosine (m6A), the most prevalent internal mRNA modification in eukaryotes, is added by m6A methyltransferases, removed by m6A demethylases and recognised by m6A‐binding proteins.
Zhi‐Man Zhu +4 more
doaj +1 more source
Functional implications of the emergence of alternative splicing in hnRNP A/B transcripts [PDF]
, 2010 The heterogeneous nuclear ribonucleoproteins (hnRNPs) A/B are a family of RNA-binding proteins that participate in various aspects of nucleic acid metabolism, including mRNA trafficking, telomere maintenance, and splicing.
Han, Siew Ping +5 more
core +1 more source
RBM10 regulates alternative splicing [PDF]
FEBS Letters, 2014 RBM10, originally called S1‐1, is a nuclear RNA‐binding protein with domains characteristic of RNA processing proteins. It has been reported that RBM10 constitutes spliceosome complexes and that RBM5, a close homologue of RBM10, regulates alternative splicing of apoptosis‐related genes, Fas and cFLIP.
Inoue, Akira +5 more
openaire +2 more sources