Results 61 to 70 of about 3,066,517 (203)

Large-scale identification and characterization of alternative splicing variants of human gene transcripts using 56 419 completely sequenced and manually annotated full-length cDNAs [PDF]

, 2006
We report the first genome-wide identification and characterization of alternative splicing in human gene transcripts based on analysis of the full-length cDNAs.
Go, M., Nakao, M., Thierry-Mieg, J., Imanishi, T., Otsuki, T., Isogai, T., Takeda, J-I, Hata, H., Koyanagi, K.O., Gojobori, T., Suzuki, Y., Nomura, N., Yura, K., Shionyu, M., Jin, L., Motono, C., Kuryshev, V., Barrero, R.A., Wiemann, S., Nagai, K., Thierry-Mieg, D., Sugano, S.   +21 more
core  

Tetracycline aptamer-controlled regulation of pre-mRNA splicing in yeast [PDF]

, 2007
Splicing of pre-mRNA is a critical step in mRNA maturation and disturbances cause several genetic disorders. We apply the synthetic tetracycline (tc)-binding riboswitch to establish a gene expression system for conditional tc-dependent control of pre ...
Weigand, Julia E., Suess, Beatrix, Weigand, Julia, Süß, Beatrix   +3 more
core   +1 more source

Functional and evolutionary analysis of alternatively spliced genes is consistent with an early eukaryotic origin of alternative splicing

BMC Evolutionary Biology, 2007
Background Alternative splicing has been reported in various eukaryotic groups including plants, apicomplexans, diatoms, amoebae, animals and fungi. However, whether widespread alternative splicing has evolved independently in the different eukaryotic ...
Penny David, Rukov Jakob, Irimia Manuel, Roy Scott   +3 more
doaj   +1 more source

Comparative analysis indicates that alternative splicing in plants has a limited role in functional expansion of the proteome [PDF]

, 2009
Background Alternative splicing (AS) is a widespread phenomenon in higher eukaryotes but the extent to which it leads to functional protein isoforms and to proteome expansion at large is still a matter of debate.
Stiekema, W., Willem J Stiekema, Severing, E.I., Roeland CHJ van Ham, Ham, R.C.H.J., van, van Dijk, A.D.J., van Ham Roeland CHJ, Dijk, A.D.J., van, van Dijk Aalt DJ, van Ham, R.C.H.J., Severing Edouard I, Edouard I Severing, Aalt DJ van Dijk, Stiekema Willem J   +13 more
core   +1 more source

Pervasive non-triplet alternative splicing drives functional isoform diversity

Nature Communications
Alternative mRNA splicing is an important mechanism for regulating gene expression and generating transcriptomic diversity. Most cases of alternative splicing studied to date are triplet, meaning that both isoforms retain the same translational reading ...
Shameerudeen Athavudeen, Neethu Issac, Adam Norris   +2 more
doaj   +1 more source

Interrogation of alternative splicing events in duplicated genes during evolution

BMC Genomics, 2011
Background Gene duplication provides resources for developing novel genes and new functions while retaining the original functions. In addition, alternative splicing could increase the complexity of expression at the transcriptome and proteome level ...
Chen Ting-Wen, Wu Timothy H, Ng Wailap V, Lin Wen-Chang   +3 more
doaj   +1 more source

Splicing therapeutics in SMN2 and APOB [PDF]

, 2009
Splicing therapeutics are defined as the deliberate modification of RNA splicing to achieve therapeutic goals. Various techniques for splicing therapeutics have been described, and most of these involve the use of antisense oligonucleotide-based ...
Krainer, AR, Khoo, B., Krainer, A. R., Khoo, B   +3 more
core  

Genome-wide survey and analysis of allele-specific mRNA splicing in human and mouse [PDF]

, 2008
Includes abstract.Includes bibliographical references (leaves 125-145).This dissertation aims to examine allele-specific splicing in human and mouse using publicly available datasets.
Nembaware, Victoria Precious
core   +1 more source

Alternative splicing regulation and its therapeutic potential in bladder cancer

Frontiers in Oncology
Bladder cancer is one of the leading causes of mortality globally. The development of bladder cancer is closely associated with alternative splicing, which regulates human gene expression and enhances the diversity of functional proteins.
Lina Li, Ting Jin, Liang Hu, Jin Ding
doaj   +1 more source

Palmitate- and C6 ceramide-induced Tnnt3 pre-mRNA alternative splicing occurs in a PP2A dependent manner

Nutrition & Metabolism, 2018
Background In a previous study, we showed that consumption of diets enriched in saturated fatty acids causes changes in alternative splicing of pre-mRNAs encoding a number of proteins in rat skeletal muscle, including the one encoding skeletal muscle ...
Adam J. Black, Rudolf J. Schilder, Scot R. Kimball   +2 more
doaj   +1 more source