Results 61 to 70 of about 3,932,181 (346)

Coupling of alternative splicing and alternative polyadenylation

Acta Biochimica et Biophysica Sinica
RNA splicing and 3'-cleavage and polyadenylation (CPA) are essential processes for the maturation of RNA. There have been extensive independent studies of these regulated processing events, including alternative splicing (AS) and alternative polyadenylation (APA).
Zhang Xueying, Liu Feiyan, Zhou Yu
openaire   +4 more sources

Alternative Splicing: Emerging Roles in Anti-Aging Strategies

Biomolecules
Alternative splicing plays a fundamental role in gene expression and protein complexity. Aberrant splicing impairs cell homeostasis and is closely associated with aging and cellular senescence.
Lingyue Gao, Rong Jia
doaj   +1 more source

The role of alternative pre-mRNA splicing in cancer progression

Cancer Cell International, 2023
Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the proteome. Recent research has highlighted the significance of specific splicing isoforms in cellular processes,
Sunkyung Choi, Namjoon Cho, Eun-Mi Kim, Kee K. Kim   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A Novel Prognostic Index Based on Alternative Splicing in Papillary Renal Cell Carcinoma

Frontiers in Genetics, 2020
BackgroundPapillary renal cell carcinoma (pRCC) is a heterogeneous multifocal or isolated tumor with an invasive phenotype. Previous studies presented that alternative splicing, as a crucial posttranscriptional regulator in gene expression, is associated
Zhipeng Wu, Jinhui Liu, Rui Sun, Dongming Chen, Kai Wang, Changchun Cao, Xianlin Xu   +6 more
doaj   +1 more source

Diverse alternative back-splicing and alternative splicing landscape of circular RNAs

Genome Research, 2016
Circular RNAs (circRNAs) derived from back-spliced exons have been widely identified as being co-expressed with their linear counterparts. A single gene locus can produce multiple circRNAs through alternative back-splice site selection and/or alternative
Xiao-Ou Zhang, Rui Dong, Yang Zhang, Jia-Lin Zhang, Zheng Luo, Jun Zhang, Ling-Ling Chen, Li Yang   +7 more
semanticscholar   +1 more source

Alternative splicing in addiction

Current Opinion in Genetics & Development
Addiction is a chronic and relapsing medical condition characterized by the compulsive use of drugs or alcohol despite harmful consequences. While transcriptional regulation has long been recognized for its role in addiction, recent genome-wide analyses have uncovered widespread alternative splicing changes that shift protein isoform diversity in ...
Akanksha Bhatnagar, Elizabeth A Heller
openaire   +2 more sources

Evolution of Alternative Splicing in Eudicots [PDF]

Frontiers in Plant Science, 2019
Alternative pre-mRNA splicing (AS) is prevalent in plants and is involved in many interactions between plants and environmental stresses. However, the patterns and underlying mechanisms of AS evolution in plants remain unclear. By analyzing the transcriptomes of four eudicot species, we revealed that the divergence of AS is largely due to the gains and
Ling, Zhihao, Brockmöller, Thomas, Baldwin, Ian T., Xu, Shuqing   +3 more
openaire   +5 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Functional and evolutionary analysis of alternatively spliced genes is consistent with an early eukaryotic origin of alternative splicing

BMC Evolutionary Biology, 2007
Background Alternative splicing has been reported in various eukaryotic groups including plants, apicomplexans, diatoms, amoebae, animals and fungi. However, whether widespread alternative splicing has evolved independently in the different eukaryotic ...
Penny David, Rukov Jakob, Irimia Manuel, Roy Scott   +3 more
doaj   +1 more source