Results 81 to 90 of about 325,117 (198)
HP1 Is Involved in Regulating the Global Impact of DNA Methylation on Alternative Splicing
Cell Reports, 2015 The global impact of DNA methylation on alternative splicing is largely unknown. Using a genome-wide approach in wild-type and methylation-deficient embryonic stem cells, we found that DNA methylation can either enhance or silence exon recognition and ...
Ahuvi Yearim +10 more
doaj +1 more source
Overestimation of alternative splicing caused by variable probe characteristics in exon arrays [PDF]
, 2017 In higher eukaryotes, alternative splicing is a common mechanism for increasing transcriptome diversity. Affymetrix exon arrays were designed as a tool for monitoring the relative expression levels of hundreds of thousands of known and predicted exons ...
Gaidatzis, Dimos +3 more
core
On the physiological significance of alternative splicing events in higher plants [PDF]
, 2012 Alternative splicing, which generates multiple transcripts from the same gene and potentially different protein isoforms, is a key posttranscriptional regulatory mechanism for expanding proteomic diversity and functional complexity in higher eukaryotes ...
Carvalho, Raquel F. +2 more
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Reciprocal intronic and exonic histone modification regions in humans. [PDF]
, 2010 While much attention has been focused on chromatin at promoters and exons, human genes are mostly composed of intronic sequences. Analyzing published surveys of nucleosomes and 41 chromatin marks in humans, we identified histone modifications ...
Guthrie, Christine +3 more
core +2 more sources
SRSF2 Is Essential For Hematopoiesis and Its Mutations Dysregulate Alternative RNA Splicing In MDS [PDF]
, 2013 Myelodysplastic syndromes (MDS) are a group of neoplasms that are ineffective in generating multiple lineages of myeloid cells and have various risks to progress to acute myeloid leukemia.
Chen, Liang +10 more
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Which Kind of Causal Specificity Matters Biologically? [PDF]
, 2017 Griffiths et al. (2015) have proposed a quantitative measure of causal specificity and used it to assess various attempts to single out genetic causes as being causally more specific than other cellular mechanisms, for example, alternative splicing ...
Weber, Marcel
core +2 more sources
Modularized Perturbation of Alternative Splicing Across Human Cancers
Frontiers in Genetics, 2019 Splicing perturbation in cancers contribute to different aspects of cancer cell progression. However, the complete functional impact of cancer-associated splicing have not been fully characterized.
Yabing Du +13 more
doaj +1 more source
MicroorganismsAlternative splicing plays a crucial role in enhancing the protein diversity of eukaryotic genomes. However, alternative splicing has not been extensively studied in Botrytis cinerea.
Ping Lu +5 more
doaj +1 more source
BRCA1 alternative splicing in breast tumorogenesis [PDF]
Introduction: Alternative splicing helps transcription process to produce many proteins from single gene and has important roles on tumorogenesis. The BRCA1 gene has almost 11 alternate spliced variants which have been mentioned as susceptibility ...
اخوان, هما +6 more
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Alternative splicing and disease
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009 Almost all protein-coding genes are spliced and their majority is alternatively spliced. Alternative splicing is a key element in eukaryotic gene expression that increases the coding capacity of the human genome and an increasing number of examples illustrates that the selection of wrong splice sites causes human disease.
Tazi, Jamal +2 more
openaire +3 more sources