Results 81 to 90 of about 3,066,517 (203)

Alternative splicing and extensive RNA editing of human TPH2 transcripts. [PDF]

, 2010
Brain serotonin (5-HT) neurotransmission plays a key role in the regulation of mood and has been implicated in a variety of neuropsychiatric conditions. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of 5-HT.
Bondy, Brigitta, Bondy, B., Baghai Thomas C., Brigitta Bondy, Peter Zill, Zill, P., Schüle Cornelius, Hammer, P., Grohmann Maik, Büttner, A., Walther Maria, Priller, Josef, Hammer Paul, Baghai, Thomas C., Maik Grohmann, Wolfgang Eisenmenger, Baghai, T., Priller Josef, Josef Priller, Walther, D.J., Eisenmenger, Wolfgang, Bader, Michael, Zill, Peter, Paul Hammer, Hammer, Paul, Rupprecht Rainer, Büttner, Andreas, Michael Bader, Andreas Büttner, Diego J Walther, Cornelius Schüle, Paulmann, Nils, Zill Peter, Bader Michael, Eisenmenger, W., Schüle, Cornelius, Maria Walther, Rainer Rupprecht, Thomas C Baghai, Paulmann Nils, Schuele, C., Walther, Diego J., Rupprecht, R., Nils Paulmann, Baghai, T.C., Eisenmenger Wolfgang, Walther, Maria, Grohmann, M., Bondy Brigitta, Walther Diego J., Bader, M., Priller, J., Paulmann, N., Büttner Andreas, Walther, M., Grohmann, Maik, Rupprecht, Rainer, Schüle, C., Walther, D., Buettner, A.   +59 more
core   +1 more source

Technological advances and computational approaches for alternative splicing analysis in single cells

Computational and Structural Biotechnology Journal, 2020
Alternative splicing of RNAs generates isoform diversity, resulting in different proteins that are necessary for maintaining cellular function and identity.
Wei Xiong Wen, Adam J. Mead, Supat Thongjuea   +2 more
doaj   +1 more source

Therapeutic potential of alternative splicing in cardiovascular diseases

EBioMedicine
Summary: RNA splicing is an important RNA processing step required by multiexon protein-coding mRNAs and some noncoding RNAs. Precise RNA splicing is required for maintaining gene and cell function; however, mis-spliced RNA transcripts can lead to loss ...
Jun Cao, Ziyu Wei, Yu Nie, Hou-Zao Chen
doaj   +1 more source

Alternative splicing and genomic stability [PDF]

Physical Biology, 2004
6 ...
openaire   +3 more sources

Identifying differential exon splicing using linear models and correlation coefficients [PDF]

, 2009
Background: With the availability of the Affymetrix exon arrays a number of tools have been developed to enable the analysis. These however can be expensive or have several pre-installation requirements.
Pallas Jacqueline A, Shah, SH, Shah Sonia H, Sonia H Shah, Jacqueline A Pallas, Shah, Sonia H., Pallas, JA, Pallas, Jacqueline A.   +7 more
core   +1 more source

Alternative splicing: The lord of the rings

Nature Plants, 2017
Fil: Ariel, Federico Damian. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Santa Fe. Instituto de Agrobiotecnologia del Litoral. Universidad Nacional del Litoral.
Ariel, Federico, Crespi, Martin
openaire   +5 more sources

Crosstalk between m6A modification and alternative splicing during cancer progression

Clinical and Translational Medicine, 2023
Background N6‐methyladenosine (m6A), the most prevalent internal mRNA modification in eukaryotes, is added by m6A methyltransferases, removed by m6A demethylases and recognised by m6A‐binding proteins.
Zhi‐Man Zhu, Fu‐Chun Huo, Jian Zhang, Hong‐Jian Shan, Dong‐Sheng Pei   +4 more
doaj   +1 more source

A method of predicting changes in human gene splicing induced by genetic variants in context of cis-acting elements [PDF]

, 2010
Background: polymorphic variants and mutations disrupting canonical splicing isoforms are among the leading causes of human hereditary disorders. While there is a substantial evidence of aberrant splicing causing Mendelian diseases, the implication of ...
Churbanov, Alexander, Hicks, Chindo, Churbanov Alexander, Chindo Hicks, Vorechovsky, Igor, Vořechovský Igor, Hicks Chindo, Igor Vořechovský, Alexander Churbanov   +8 more
core   +1 more source

Genome-wide analysis of gene expression and alternative splicing in human medulloblastoma [PDF]

, 2010
Medulloblastoma is a malignant embryonal tumour of the cerebellum which most commonly affects children. A subset of tumours is thought to arise from cerebellar granule cell precursors (GCPs) that fail to undergo normal neuronal development, following ...
Menghi, F.
core  

Cell-specific exon methylation and CTCF binding in neurons regulate calcium ion channel splicing and function

eLife, 2020
Cell-specific alternative splicing modulates myriad cell functions and is disrupted in disease. The mechanisms governing alternative splicing are known for relatively few genes and typically focus on RNA splicing factors.
Eduardo Javier López Soto, Diane Lipscombe   +1 more
doaj   +1 more source