Results 101 to 110 of about 325,117 (198)

Alternative splicing in addiction

Current Opinion in Genetics & Development
Addiction is a chronic and relapsing medical condition characterized by the compulsive use of drugs or alcohol despite harmful consequences. While transcriptional regulation has long been recognized for its role in addiction, recent genome-wide analyses have uncovered widespread alternative splicing changes that shift protein isoform diversity in ...
Akanksha Bhatnagar, Elizabeth A Heller
openaire   +2 more sources

Identification of an Alternative Exon in a GABA Receptor Gene [PDF]

, 2018
The central dogma of biology states that DNA is transcribed into mRNA, which is then translated into proteins. In order for translation to occur, pre-mRNAs first must be processed.
Apgar, Shannon, Toro, Cecilia P.
core   +1 more source

Latent rank change detection for analysis of splice-junction microarrays with nonlinear effects

, 2011
Alternative splicing of gene transcripts greatly expands the functional capacity of the genome, and certain splice isoforms may indicate specific disease states such as cancer.
Burns, Suzanne, Burton, Tarea, Gelfond, Jonathan, Penalva, Luiz O. F., Sogayar, Mari, Zarzabal, Lee Ann   +5 more
core   +1 more source

A polynomial delay algorithm for the enumeration of bubbles with length constraints in directed graphs and its application to the detection of alternative splicing in RNA-seq data

, 2013
We present a new algorithm for enumerating bubbles with length constraints in directed graphs. This problem arises in transcriptomics, where the question is to identify all alternative splicing events present in a sample of mRNAs sequenced by RNA-seq ...
Lacroix, Vincent, Sacomoto, Gustavo, Sagot, Marie-France   +2 more
core   +1 more source

Coupling of alternative splicing and alternative polyadenylation

Acta Biochimica et Biophysica Sinica
RNA splicing and 3′-cleavage and polyadenylation (CPA) are essential processes for the maturation of RNA. There have been extensive independent studies of these regulated processing events, including alternative ...
Zhang Xueying, Liu Feiyan, Zhou Yu
doaj   +1 more source

MicroRNA-Mediated Obstruction of Stem-loop Alternative Splicing (MIMOSAS) regulates long-range alternative splicing in Drosophila. [PDF]

Nucleic Acids Res
Ruan K, Liu J, Xia M, Bertolotti F, Hofacker I, Wuchty S, Zhai RG.   +6 more
europepmc   +1 more source

PCBP1 regulates alternative splicing of AARS2 in congenital cardiomyopathy. [PDF]

Nat Cardiovasc Res
Lu YW, Liang Z, Dorr K, Ruiz S, Huang X, Fangnibo Hanvi D, Juntilla SM, Beutner G, Lyu S, Guo H, Fernandes T, Espinoza-Lewis RA, Wang T, Li K, Li X, Bir Singh G, Wang Y, Deng R, Cowan D, Mably JD, Pu WT, Huang J, Porter GA, Conlon F, Chen H, Wang DZ.   +25 more
europepmc   +1 more source

TDP43 and hnRNP K Regulate Alternative Splicing of DNAJC5. [PDF]

Cell Biol Int
Nagasse HY, Okuda EK, Coltri PP.
europepmc   +1 more source

Detection of alternative splicing: deep sequencing or deep learning? [PDF]

Brief Bioinform
Hackl LM, Neuhaus F, Ameling S, Völker U, Baumbach J, Tsoy O.   +5 more
europepmc   +1 more source

Role of Alternative Splicing and Polyadenylation in Regulation of Spleen Development. [PDF]

Cells
Cui J, Zhu R, Song M, Sun Y, Pang Y, Tian M, He X, Liu D, Yang X.   +8 more
europepmc   +1 more source