Results 101 to 110 of about 3,066,517 (203)

Identification of alternative splicing regulatory patterns and characteristic splicing factors in heart failure using RNA-seq data and machine learning

Heliyon
Heart failure (HF) represents the advanced stage of several cardiovascular disorders. This study aimed to build an alternative splicing regulatory network and identify potential splicing factors involved in HF utilizing RNA-seq data and machine learning ...
Jia Li, Dingyuan Tu, Songhua Li, Zhifu Guo, Xiaowei Song   +4 more
doaj   +1 more source

Construction of an Automatic Update Alternative Splicing Database

, 2009
[[abstract]]In the past several years, the analysis of alternative splicing and its application to identify the origins of disease has been gaining momentum. Therefore, we developed a value added transcriptome database (Avatar).
Shih Min Yao
core  

Genome-Wide Identification of Alternative Splicing in Botrytis cinerea During Infection Stage of Solanum lycopersicum

Microorganisms
Alternative splicing plays a crucial role in enhancing the protein diversity of eukaryotic genomes. However, alternative splicing has not been extensively studied in Botrytis cinerea.
Ping Lu, Yun Wang, Xiaoli Wang, Jiaqi Wang, Dan Wang, Haojie Shi   +5 more
doaj   +1 more source

Mechanisms 
of
 change 
in 
protein 
architecture [PDF]

, 2011
Proteins are the basic building blocks and functional units in all living organisms. Moreover, differences between species can frequently be explained with differences in their protein complements.

core   +2 more sources

Alternative splicing in stem cells and development: research progress and emerging technologies

Cell Regeneration
Alternative splicing is a key regulatory mechanism that generates transcriptomic diversity by selectively splicing pre-RNA molecules in different ways, leading to the production of multiple RNA isoforms from a single gene. This process is crucial for the
Yan Jin, XiaoLin Liang, Xiangting Wang
doaj   +1 more source

A Ralstonia solanacearum Effector Targets Splicing Factor SR34a to Reprogram Alternative Splicing and Regulate Plant Immunity

Plants
Alternative splicing is a critical post-transcriptional regulatory mechanism in eukaryotes. While infection with Ralstonia solanacearum GMI1000 significantly alters plant alternative splicing patterns, the underlying molecular mechanisms remain unclear ...
Yunyun Li, Song Kou
doaj   +1 more source

Alternative Splicing Regulation of Cancer-Related Pathways in Caenorhabditis elegans: An In Vivo Model System with a Powerful Reverse Genetics Toolbox

International Journal of Cell Biology, 2013
Alternative splicing allows for the generation of protein diversity and fine-tunes gene expression. Several model systems have been used for the in vivo study of alternative splicing. Here we review the use of the nematode Caenorhabditis elegans to study
Sergio Barberán-Soler, James Matthew Ragle   +1 more
doaj   +1 more source

Discovering Association between Alternative Splicing and Disease

, 2009
[[abstract]]Alternative splicing is important because more proteins can be made from the relative few genes and. it is also an important mechanism regulating genetic expression.
ku tien hsiung
core  

Large-scale analysis of human alternative protein isoforms: pattern classification and correlation with subcellular localization signals [PDF]

, 2005
We investigated human alternative protein isoforms of >2600 genes based on full-length cDNA clones and SwissProt. We classified the isoforms and examined their co-occurrence for each gene.
Nakao, M., Suwa, M., Motono, C., Barrero, R.A., Mukai, Y., Nakai, K.   +5 more
core  

Comparative Analysis of Alternative Splicing Events in Human and Mouse

, 2009
[[abstract]]Comparison of human and mouse genomics revealed a similar long range sequences organization, and many genes that are orthologous between human and mouse.
Liu Chia Hung
core