Results 1 to 10 of about 215,019 (165)
Exon inclusion signatures enable accurate estimation of splicing factor activity. [PDF]
Nat CommunSplicing factors control exon inclusion in messenger RNAs, shaping transcriptome and proteome diversity. Their catalytic activity is regulated by multiple layers, making single-omic measurements on their own fall short in identifying which splicing ...
Anglada-Girotto M +6 more
europepmc +2 more sources
Split-APEX implicates splicing factor SRSF1 and splicing helicases in ribosomal biogenesis. [PDF]
Front Mol BiosciSR proteins are RNA-binding proteins with one or two RNA recognition motif (RRM)-type RNA-binding domains and a C-terminal region rich in arginine-serine dipeptides. They function in cellular processes ranging from transcription to translation.
Paschalis V +16 more
europepmc +2 more sources
An overview of RNA splicing and functioning of splicing factors in land plant chloroplasts
RNA Biology, 2022 RNA splicing refers to a process by which introns of a pre-mRNA are excised and the exons at both ends are joined together. Chloroplast introns are inherently self-splicing ribozymes, but over time, they have lost self-splicing ability due to the ...
Xuemei Wang +4 more
doaj +3 more sources
Control of 3' splice site selection by the yeast splicing factor Fyv6. [PDF]
ElifeABSTRACT Pre-mRNA splicing is catalyzed in two steps: 5ʹ splice site (SS) cleavage and exon ligation. A number of proteins transiently associate with spliceosomes to specifically impact these steps (1 st and 2 nd step factors).
Senn KA +5 more
europepmc +5 more sources
Neural Regeneration Research, 2023 Alternative splicing is the process of producing variably spliced mRNAs by choosing distinct combinations of splice sites within a messenger RNA precursor.
Ana M Sandoval-Castellanos +4 more
doaj +1 more source
CRISPR artificial splicing factors [PDF]
Nature Communications, 2020 Abstract Alternative splicing allows expression of mRNA isoforms from a single gene, expanding the diversity of the proteome. Its prevalence in normal biological and disease processes warrant precise tools for modulation.
Menghan Du +4 more
openaire +4 more sources
Frontiers in Cell and Developmental Biology, 2023 Splicing abnormality resulting from somatic mutations in key splicing factor genes (SFG) has been detected in various cancers. Hence, an in-depth study of splicing factor genes mutations’ impact on pan-cancer is meaningful.
Jiangti Luo +9 more
doaj +1 more source
Processive phosphorylation of alternative splicing factor/splicing factor 2 [PDF]
Proceedings of the National Academy of Sciences, 2003 SR proteins, named for their multiple arginine/serine (RS) dipeptide repeats, are critical components of the spliceosome, influencing both constitutive and alternative splicing of pre-mRNA. SR protein function is regulated through phosphorylation of their RS domains by multiple kinases, including a family of evolutionarily conserved SR protein-specific
Brandon E, Aubol +7 more
openaire +2 more sources
Splicing factor mutations in hematologic malignancies [PDF]
Blood, 2021 Abstract Mutations in genes encoding RNA splicing factors were discovered nearly 10 years ago and are now understood to be among the most recurrent genetic abnormalities in patients with all forms of myeloid neoplasms and several types of lymphoproliferative disorders, as well as subjects with clonal hematopoiesis.
Sisi Chen +2 more
openaire +2 more sources
Alternative Splicing Events and Splicing Factors Are Prognostic in Adrenocortical Carcinoma [PDF]
Frontiers in Genetics, 2020 Alternative splicing is involved in the pathogenesis of human diseases, including cancer. Here, we investigated the potential application of alternative splicing events (ASEs) and splicing factors (SFs) in the prognosis of adrenocortical carcinoma (ACC).
Jian Lv +5 more
openaire +3 more sources