Results 21 to 30 of about 225,555 (308)

Perturbation of chromatin structure globally affects localization and recruitment of splicing factors [PDF]

, 2012
Chromatin structure is an important factor in the functional coupling between transcription and mRNA processing, not only by regulating alternative splicing events, but also by contributing to exon recognition during constitutive splicing.
Risso, Guillermo, J, Risso Guillermo J., Lleres, D, Jernej Ule, Ignacio E. Schor (120406), Llères, David, Llères David, Pawellek, A., Ule, J., Kornblihtt Alberto R., Schor, Ignacio, E, Risso, GJ, Ule, Jernej, Lamond, Angus I.; id_orcid, Lamond, A.I., Alberto R. Kornblihtt (120413), Lamond, Angus, I, Kornblihtt, Alberto, R, Pawellek, Andrea, Andrea Pawellek, Alberto R Kornblihtt, David Llères (68840), Guillermo J. Risso (120408), Andrea Pawellek (120410), Risso, Guillermo J., Schor*, I.E., Schor, I.E., Lamond Angus I., Schor, Ignacio E., Ule, J, Ule Jernej, Risso, G.J., David Llères, Kornblihtt, A.R., Ignacio E Schor, Pawellek Andrea, Lleres*, D., Lamond, AI, Guillermo J Risso, Angus I Lamond, Kornblihtt, Alberto R., Llères, D., Schor Ignacio E., Pawellek, A, Schor, IE, Angus I. Lamond (13065), Kornblihtt, AR, Jernej Ule (115588)   +47 more
core   +1 more source

Replication stress signaling is a therapeutic target in myelodysplastic syndromes with splicing factor mutations

Haematologica, 2020
Somatic mutations in genes coding for splicing factors, e.g., SF3B1, U2AF1, SRSF2, and others are found in approximately 50% of patients with myelodysplastic syndromes (MDS).
Johanna Flach, Johann-Christoph Jann, Antje Knaflic, Vladimir Riabov, Alexander Streuer, Eva Altrock, Qingyu Xu, Nanni Schmitt, Julia Obländer, Verena Nowak, Justine Danner, Arwin Mehralivand, Franziska Hofmann, Iris Palme, Ahmed Jawhar, Patrick Wuchter, Georgia Metzgeroth, Florian Nolte, Wolf-Karsten Hofmann, Daniel Nowak   +19 more
doaj   +1 more source

Comprehensive Analysis of Prognostic Alternative Splicing Signature Reveals Recurrence Predictor for Papillary Thyroid Cancer

Frontiers in Oncology, 2021
BackgroundAlternative splicing (AS) plays a key role in the diversity of proteins and is closely associated with tumorigenicity. The aim of this study was to systemically analyze RNA alternative splicing (AS) and identify its prognostic value for ...
Mian Liu, Rooh Afza Khushbu, Pei Chen, Hui-Yu Hu, Neng Tang, Deng-jie Ou-yang, Bo Wei, Ya-xin Zhao, Peng Huang, Peng Huang, Shi Chang, Shi Chang, Shi Chang   +12 more
doaj   +1 more source

Screening and Identification of Survival-Associated Splicing Factors in Lung Squamous Cell Carcinoma

Frontiers in Genetics, 2022
Lung squamous cell carcinoma (LUSC) is a disease with high morbidity and mortality. Many studies have shown that aberrant alternative splicing (AS) can lead to tumorigenesis, and splicing factors (SFs) serve as an important function during AS.
Min Chen, Rui Zhu, Fangzhou Zhang, Fangzhou Zhang, Liucun Zhu   +4 more
doaj   +1 more source

Identification of the prognostic signature based on genomic instability-related alternative splicing in colorectal cancer and its regulatory network

Frontiers in Bioengineering and Biotechnology, 2022
Background: Colorectal cancer (CRC) is a heterogeneous disease with many somatic mutations defining its genomic instability. Alternative Splicing (AS) events, are essential for maintaining genomic instability.
Qiuying Ding, Zhengping Hou, Zhibo Zhao, Yao Chen, Lei Zhao, Yue Xiang   +5 more
doaj   +1 more source

Regulation of alternative splicing by p300-mediated acetylation of splicing factors [PDF]

RNA, 2019
Splicing of precursor mRNA (pre-mRNA) is an important regulatory step in gene expression. Recent evidence points to a regulatory role of chromatin-related proteins in alternative splicing regulation. Using an unbiased approach, we have identified the acetyltransferase p300 as a key chromatin-related regulator of alternative splicing.
Siam, Ahmad, Baker, Mai, Amit, Leah, Regev, Gal, Rabner, Alona, Najar, Rauf Ahmad, Bentata, Mercedes, Dahan, Sara, Cohen, Klil, Araten, Sarah, Nevo, Yuval, Kay, Gillian, Mandel-Gutfreund, Yael, Salton, Maayan   +13 more
openaire   +2 more sources

Characterization of factors involved in the coupling of 3' end processing and splicing and in the 3' end formation of mRNA precursors [PDF]

, 2006
Eukaryotic mRNA precursors are processed at their 5’ and 3’ ends and are spliced prior to their export from the nucleus to the cytoplasm. Although all three processing reactions can be studied separately in vitro, they are coupled in vivo.
Kyburz Kooznetsoff, Andrea Martina
core   +1 more source

Targeting splicing factors for cancer therapy

RNA, 2023
Alternative splicing (AS) of mRNAs is an essential regulatory mechanism in eukaryotic gene expression. AS misregulation, caused by either dysregulation or mutation of splicing factors, has been shown to be involved in cancer development and progression, making splicing factors suitable targets for cancer therapy.
Ariel Bashari, Zahava Siegfried, Rotem Karni   +2 more
openaire   +2 more sources

SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells

Tumor Biology, 2017
Splicing factor 3b subunit 4, a critical component of pre-message RNA splicing complex, has been reported to play an important part in the tumorigenesis.
Wentao Zhou, Ning Ma, Hao Jiang, Yefei Rong, Yuezhen Deng, Yuanyuan Feng, Hongxu Zhu, Tiantao Kuang, Wenhui Lou, Dong Xie, Dansong Wang   +10 more
doaj   +1 more source

Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis

Disease Models & Mechanisms, 2018
RNA splicing factors are essential for the viability of all eukaryotic cells; however, in metazoans some cell types are exquisitely sensitive to disruption of splicing factors.
Shelly Sorrells, Sara Nik, Mattie Casey, Rosannah C. Cameron, Harold Truong, Cristhian Toruno, Michelle Gulfo, Albert Lowe, Cicely Jette, Rodney A. Stewart, Teresa V. Bowman   +10 more
doaj   +1 more source