Results 41 to 50 of about 215,019 (165)
Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells. [PDF]
PLoS ONE, 2011 Alternative splicing involves differential exon selection of a gene transcript to generate mRNA and protein isoforms with structural and functional diversity.
Jan-Gowth Chang +9 more
doaj +1 more source
The emerging role of splicing factors in cancer [PDF]
The EMBO Reports, 2008 Recent progress in global sequence and microarray data analysis has revealed the increasing complexity of the human transcriptome. Alternative splicing generates a huge diversity of transcript variants and disruption of splicing regulatory networks is emerging as an important contributor to various diseases, including cancer.
Ana Rita, Grosso +2 more
openaire +2 more sources
Splicing factors in the heart: Uncovering shared and unique targets
Journal of Molecular and Cellular Cardiology, 2023 Alternative splicing generates specialized protein isoforms that allow the heart to adapt during development and disease. The recent discovery that mutations in the splicing factor RNA-binding protein 20 (RBM20) cause a severe form of familial dilated cardiomyopathy has sparked a great interest in alternative splicing in the field of cardiology.
Montañés-Agudo, Pablo +2 more
openaire +2 more sources
Alterations of RNA splicing patterns in esophagus squamous cell carcinoma
Cell & Bioscience, 2021 Alternative splicing (AS) is an important biological process for regulating the expression of various isoforms from a single gene and thus to promote proteome diversity.
Jiyu Ding +13 more
doaj +1 more source
The regulatory role of alternative splicing in inflammatory bowel disease
Frontiers in Immunology, 2023 Inflammatory bowel disease (IBD) mainly includes Crohn’s disease and ulcerative colitis. These diseases have a progressive course of chronic relapse and remission and affect a large number of children and adults worldwide.
Jianli Zhou +8 more
doaj +1 more source
A novel Splicing Factor that Affects Titin Alternative Splicing [PDF]
Biophysical Journal, 2011 Cardiac muscle expresses predominantly larger N2BA titin isoforms at embryonic and prenatal stages of development, and these are mostly replaced with a smaller N2B isoform in adults. We have previously discovered a mutation in rats that dramatically alters titin splicing (Greaser et al J Mol Cell Cardiol 44:982, 2008).
Guo, Wei +11 more
openaire +1 more source
Aurora-A phosphorylates splicing factors and regulates alternative splicing [PDF]
, 2020 ABSTRACT Aurora-A kinase is well known to regulate progression through mitosis. However, the kinase also performs additional functions that could explain the failure of its inhibitors to be effective in cancer treatments. To identify these functions, we applied a proteomics approach to search for interactors of Aurora-
Damodaran, Arun Prasath +11 more
openaire +1 more source
MALAT1 modulates alternative splicing by cooperating with the splicing factors PTBP1 and PSF
Science Advances, 2022 Understanding how long noncoding RNAs (lncRNAs) cooperate with splicing factors (SFs) in alternative splicing (AS) control is fundamental to human biology and disease. We show that metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a well-documented AS-implicated lncRNA, regulates AS via two SFs, polypyrimidine tract–binding protein 1 ...
Hui Miao +11 more
openaire +2 more sources
Animal Cells and SystemsLamin B1, a crucial component of the nuclear lamina, plays a pivotal role in chromatin organization and transcriptional regulation in eukaryotic cells. While recent studies have highlighted the connection between Lamin B1 and RNA splicing regulation, the
Geun-Seup Shin +9 more
doaj +1 more source
Scientific ReportsGerminal center B cells play a pivotal role in the generation of long-lived plasma cells and high-affinity antibodies. Although RNA splicing and alternative splicing are known to regulate germinal center B cell responses, the upstream mechanisms ...
Silu Li +7 more
doaj +1 more source