RNA Splicing Factors and RNA-Directed DNA Methylation [PDF]
Biology, 2014 RNA-directed histone and/or DNA modification is a conserved mechanism for the establishment of epigenetic marks from yeasts and plants to mammals.
Chao-Feng Huang, Jian-Kang Zhu
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Molecular arms races at the virus-host splicing interface and their pathogenic implications [PDF]
Frontiers in MicrobiologyRNA splicing is a fundamental driver of eukaryotic transcriptomic and proteomic diversity. Constrained by compact genomes, diverse DNA and RNA viruses, including adenovirus, HIV-1, and influenza virus, have evolved to hijack the host splicing machinery ...
Yu Chen +4 more
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RNA splicing factors as oncoproteins and tumour suppressors [PDF]
Nature Reviews Cancer, 2016 Eunhee Kim +2 more
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Regulation of RNA Splicing: Aberrant Splicing Regulation and Therapeutic Targets in Cancer
Cells, 2021 RNA splicing is a critical step in the maturation of precursor mRNA (pre-mRNA) by removing introns and exons. The combination of inclusion and exclusion of introns and exons in pre-mRNA can generate vast diversity in mature mRNA from a limited number of ...
Koji Kitamura, Keisuke Nimura
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An overview of RNA splicing and functioning of splicing factors in land plant chloroplasts
RNA Biology, 2022 RNA splicing refers to a process by which introns of a pre-mRNA are excised and the exons at both ends are joined together. Chloroplast introns are inherently self-splicing ribozymes, but over time, they have lost self-splicing ability due to the ...
Xuemei Wang +4 more
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Incorporating evolutionary information and functional domains for identifying RNA splicing factors in humans. [PDF]
PLoS ONE, 2011 Regulation of pre-mRNA splicing is achieved through the interaction of RNA sequence elements and a variety of RNA-splicing related proteins (splicing factors).
Justin Bo-Kai Hsu +3 more
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Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing
Nature Communications, 2022 Wiskott-Aldrich syndrome is caused by mutations in WASP, but the underlying mechanisms remain to be explored. Here the authors reveal that WASP deficiency results in aberrant RNA splicing, and that WASP regulates the transcription of splicing factor ...
Baolei Yuan +35 more
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RNA splicing alterations in lung cancer pathogenesis and therapy
Cancer Pathogenesis and Therapy, 2023 RNA splicing alterations are widespread and play critical roles in cancer pathogenesis and therapy. Lung cancer is highly heterogeneous and causes the most cancer-related deaths worldwide.
Yueren Yan +3 more
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Asian Journal of Andrology, 2023 A complete proteomics study characterizing active androgen receptor (AR) complexes in prostate cancer (PCa) cells identified a diversity of protein interactors with tumorigenic annotations, including known RNA splicing factors.
Sean Seltzer +4 more
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The Interplay Between the DNA Damage Response, RNA Processing and Extracellular Vesicles
Frontiers in Oncology, 2020 RNA processing was recently found to affect DNA damage response. The RNA processing factors THRAP3 and BCLAF1 play critical role in keeping DNA genomic stability by regulating the transcription, mRNA splicing and export of DNA repair proteins BRCA2 ...
Xiangbing Meng +4 more
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