Results 11 to 20 of about 162,632 (256)

RNA-Binding Proteins: Splicing Factors and Disease [PDF]

Biomolecules, 2015
Pre-mRNA splicing is mediated by interactions of the Core Spliceosome and an array of accessory RNA binding proteins with cis-sequence elements. Splicing is a major regulatory component in higher eukaryotes.
Alger M. Fredericks, Kamil J. Cygan, Brian A. Brown, William G. Fairbrother   +3 more
doaj   +3 more sources

Molecular impact of mutations in RNA splicing factors in cancer. [PDF]

Mol Cell
Somatic mutations in genes encoding components of the RNA splicing machinery occur frequently in multiple forms of cancer. The most frequently mutated RNA splicing factors in cancer impact intronic branch site and 3' splice site recognition. These include mutations in the core RNA splicing factor SF3B1 as well as mutations in the U2AF1/2 heterodimeric ...
Zhang Q, Ai Y, Abdel-Wahab O.
europepmc   +3 more sources

MYC-mediated transcriptional control of splicing factors promotes RNA splicing in activated B lymphocytes

Scientific Reports
Germinal center B cells play a pivotal role in the generation of long-lived plasma cells and high-affinity antibodies. Although RNA splicing and alternative splicing are known to regulate germinal center B cell responses, the upstream mechanisms ...
Silu Li, Chengyu Yang, Jiayuan Li, Zhenya Liu, Fenfang Gong, Xiaosu Ke, Gui-Xin Ruan, Hengjun Huang   +7 more
doaj   +4 more sources

The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations

RNA Biology, 2023
The process of alternative splicing (AS) is widely deregulated in a variety of cancers. Splicing is dependent upon splicing factors. Recently, several long noncoding RNAs (lncRNAs) have been shown to regulate AS by directly/indirectly interacting with splicing factors.
Pushkar Malakar, Sudhanshu Shukla, Meghna Mondal, Rajesh Kumar Kar, Jawed Akhtar Siddiqui   +4 more
openaire   +3 more sources

Colocalization of intranuclear lamin foci with RNA splicing factors [PDF]

Journal of Cell Science, 1999
ABSTRACT The lamins form a fibrous network underlying the inner nuclear membrane termed the nuclear lamina. In order to gain insights into the role of lamins in nuclear organization, we have characterized a monoclonal antibody (LA-2H10) raised against recombinant rat lamin A that labels nuclei in a speckled pattern in all cells of ...
Jagatheesan, G, Thanumalayan, S, Muralikrishna, Bh, Rangaraj, Nandini, Karande, Anjali A, Parnaik, Veena K   +5 more
openaire   +3 more sources

AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors [PDF]

Nature Communications, 2016
AbstractAlternative splicing of pre-mRNAs significantly contributes to the complexity of gene expression in higher organisms, but the regulation of the splice site selection remains incompletely understood. We have previously demonstrated that a chromatin-associated protein, AKAP95, has a remarkable activity in enhancing chromatin transcription.
Hu, J., Khodadadi-Jamayran, A., Mao, M., Shah, K., Yang, Z., Nasim, Md. Talat, Wang, Z., Jiang, H.   +7 more
openaire   +4 more sources

Activation and Spatial Redistribution of RNA Splicing Factors Trigger Hepatic Regeneration. [PDF]

Cell Mol Gastroenterol Hepatol
Tissue injury with regenerative obstacle leads to liver failure and inevitable consequent hepatic diseases. Yet, precise spatial and molecular alterations to initiate liver regeneration remain unknown.We employed spatiotemporal sequencing of regenerating liver combined with high-throughput single-cell RNA sequencing of established hepatocyte organoids (
An Y, Lian J, Wei W, Mao Y, Qiao L, Li T, Li R, Li S, Zhao S, Chen X, Zhao H, Hu H.   +11 more
europepmc   +4 more sources

SFMetaDB: a comprehensive annotation of mouse RNA splicing factor RNA-Seq datasets [PDF]

Database, 2017
Abstract Although the number of RNA-Seq datasets deposited publicly has increased over the past few years, incomplete annotation of the associated metadata limits their potential use. Because of the importance of RNA splicing in diseases and biological processes, we constructed a database called SFMetaDB by curating datasets related ...
Jin Li, Ching-San Tseng, Antonio Federico, Franjo Ivankovic, Yi-Shuian Huang, Alfredo Ciccodicola, Maurice S. Swanson, Peng Yu   +7 more
openaire   +2 more sources

SCR106 splicing factor modulates abiotic stress responses by maintaining RNA splicing in rice

Journal of Experimental Botany, 2023
Abstract Plants employ sophisticated molecular machinery to fine-tune their responses to growth, developmental, and stress cues. Gene expression influences plant cellular responses through regulatory processes such as transcription and splicing.
Abdulrahman Alhabsi, Haroon Butt, Gwendolyn K Kirschner, Ikram Blilou, Magdy M Mahfouz   +4 more
openaire   +3 more sources

Integrated analysis of a compendium of RNA-Seq datasets for splicing factors [PDF]

Scientific Data, 2020
Abstract A vast amount of public RNA-sequencing datasets have been generated and used widely to study transcriptome mechanisms. These data offer precious opportunity for advancing biological research in transcriptome studies such as alternative splicing.
Yu, Peng, Li, Jin, Deng, Su-Ping, Zhang, Feiran, Grozdanov, Petar N., Chin, Eunice W. M., Martin, Sheree D., Vergnes, Laurent, Islam, M. Saharul, Sun, Deqiang, LaSalle, Janine M., McGee, Sean L., Goh, Eyleen, MacDonald, Clinton C., Jin, Peng   +14 more
openaire   +4 more sources