Results 11 to 20 of about 161,850 (258)
RNA splicing factors as oncoproteins and tumour suppressors [PDF]
Nature Reviews Cancer, 2016 The recent genomic characterization of cancers has revealed recurrent somatic point mutations and copy number changes affecting genes encoding RNA splicing factors. Initial studies of these 'spliceosomal mutations' suggest that the proteins bearing these mutations exhibit altered splice site and/or exon recognition preferences relative to their wild ...
Heidi Dvinge +2 more
exaly +6 more sources
An overview of RNA splicing and functioning of splicing factors in land plant chloroplasts
RNA Biology, 2022 RNA splicing refers to a process by which introns of a pre-mRNA are excised and the exons at both ends are joined together. Chloroplast introns are inherently self-splicing ribozymes, but over time, they have lost self-splicing ability due to the ...
Xuemei Wang +4 more
doaj +3 more sources
RNA Splicing Factors and RNA-Directed DNA Methylation [PDF]
Biology, 2014 RNA-directed histone and/or DNA modification is a conserved mechanism for the establishment of epigenetic marks from yeasts and plants to mammals.
Chao-Feng Huang, Jian-Kang Zhu
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RNA-Binding Proteins: Splicing Factors and Disease [PDF]
Biomolecules, 2015 Pre-mRNA splicing is mediated by interactions of the Core Spliceosome and an array of accessory RNA binding proteins with cis-sequence elements. Splicing is a major regulatory component in higher eukaryotes.
Alger M. Fredericks +3 more
doaj +3 more sources
Molecular arms races at the virus-host splicing interface and their pathogenic implications [PDF]
Frontiers in MicrobiologyRNA splicing is a fundamental driver of eukaryotic transcriptomic and proteomic diversity. Constrained by compact genomes, diverse DNA and RNA viruses, including adenovirus, HIV-1, and influenza virus, have evolved to hijack the host splicing machinery ...
Yu Chen +4 more
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Molecular impact of mutations in RNA splicing factors in cancer. [PDF]
Mol CellSomatic mutations in genes encoding components of the RNA splicing machinery occur frequently in multiple forms of cancer. The most frequently mutated RNA splicing factors in cancer impact intronic branch site and 3' splice site recognition. These include mutations in the core RNA splicing factor SF3B1 as well as mutations in the U2AF1/2 heterodimeric ...
Zhang Q, Ai Y, Abdel-Wahab O.
europepmc +3 more sources
Scientific ReportsGerminal center B cells play a pivotal role in the generation of long-lived plasma cells and high-affinity antibodies. Although RNA splicing and alternative splicing are known to regulate germinal center B cell responses, the upstream mechanisms ...
Silu Li +7 more
doaj +4 more sources
Regulation of RNA Splicing: Aberrant Splicing Regulation and Therapeutic Targets in Cancer
Cells, 2021 RNA splicing is a critical step in the maturation of precursor mRNA (pre-mRNA) by removing introns and exons. The combination of inclusion and exclusion of introns and exons in pre-mRNA can generate vast diversity in mature mRNA from a limited number of ...
Koji Kitamura, Keisuke Nimura
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The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations
RNA Biology, 2023 The process of alternative splicing (AS) is widely deregulated in a variety of cancers. Splicing is dependent upon splicing factors. Recently, several long noncoding RNAs (lncRNAs) have been shown to regulate AS by directly/indirectly interacting with splicing factors.
Pushkar Malakar +4 more
openaire +3 more sources
Incorporating evolutionary information and functional domains for identifying RNA splicing factors in humans. [PDF]
PLoS ONE, 2011 Regulation of pre-mRNA splicing is achieved through the interaction of RNA sequence elements and a variety of RNA-splicing related proteins (splicing factors).
Justin Bo-Kai Hsu +3 more
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