Results 21 to 30 of about 161,850 (258)

Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing

Nature Communications, 2022
Wiskott-Aldrich syndrome is caused by mutations in WASP, but the underlying mechanisms remain to be explored. Here the authors reveal that WASP deficiency results in aberrant RNA splicing, and that WASP regulates the transcription of splicing factor ...
Baolei Yuan, Xuan Zhou, Keiichiro Suzuki, Gerardo Ramos-Mandujano, Mengge Wang, Muhammad Tehseen, Lorena V. Cortés-Medina, James J. Moresco, Sarah Dunn, Reyna Hernandez-Benitez, Tomoaki Hishida, Na Young Kim, Manal M. Andijani, Chongwei Bi, Manching Ku, Yuta Takahashi, Jinna Xu, Jinsong Qiu, Ling Huang, Christopher Benner, Emi Aizawa, Jing Qu, Guang-Hui Liu, Zhongwei Li, Fei Yi, Yanal Ghosheh, Changwei Shao, Maxim Shokhirev, Patrizia Comoli, Francesco Frassoni, John R. Yates, Xiang-Dong Fu, Concepcion Rodriguez Esteban, Samir Hamdan, Mo Li, Juan Carlos Izpisua Belmonte   +35 more
doaj   +1 more source

Colocalization of intranuclear lamin foci with RNA splicing factors [PDF]

Journal of Cell Science, 1999
ABSTRACT The lamins form a fibrous network underlying the inner nuclear membrane termed the nuclear lamina. In order to gain insights into the role of lamins in nuclear organization, we have characterized a monoclonal antibody (LA-2H10) raised against recombinant rat lamin A that labels nuclei in a speckled pattern in all cells of ...
Jagatheesan, G, Thanumalayan, S, Muralikrishna, Bh, Rangaraj, Nandini, Karande, Anjali A, Parnaik, Veena K   +5 more
openaire   +3 more sources

AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors [PDF]

Nature Communications, 2016
AbstractAlternative splicing of pre-mRNAs significantly contributes to the complexity of gene expression in higher organisms, but the regulation of the splice site selection remains incompletely understood. We have previously demonstrated that a chromatin-associated protein, AKAP95, has a remarkable activity in enhancing chromatin transcription.
Hu, J., Khodadadi-Jamayran, A., Mao, M., Shah, K., Yang, Z., Nasim, Md. Talat, Wang, Z., Jiang, H.   +7 more
openaire   +4 more sources

RNA splicing alterations in lung cancer pathogenesis and therapy

Cancer Pathogenesis and Therapy, 2023
RNA splicing alterations are widespread and play critical roles in cancer pathogenesis and therapy. Lung cancer is highly heterogeneous and causes the most cancer-related deaths worldwide.
Yueren Yan, Yunpeng Ren, Yufang Bao, Yongbo Wang   +3 more
doaj   +1 more source

Investigation of androgen receptor-dependent alternative splicing has identified a unique subtype of lethal prostate cancer

Asian Journal of Andrology, 2023
A complete proteomics study characterizing active androgen receptor (AR) complexes in prostate cancer (PCa) cells identified a diversity of protein interactors with tumorigenic annotations, including known RNA splicing factors.
Sean Seltzer, Paresa N Giannopoulos, Tarek A Bismar, Mark Trifiro, Miltiadis Paliouras   +4 more
doaj   +1 more source

Activation and Spatial Redistribution of RNA Splicing Factors Trigger Hepatic Regeneration. [PDF]

Cell Mol Gastroenterol Hepatol
Tissue injury with regenerative obstacle leads to liver failure and inevitable consequent hepatic diseases. Yet, precise spatial and molecular alterations to initiate liver regeneration remain unknown.We employed spatiotemporal sequencing of regenerating liver combined with high-throughput single-cell RNA sequencing of established hepatocyte organoids (
An Y, Lian J, Wei W, Mao Y, Qiao L, Li T, Li R, Li S, Zhao S, Chen X, Zhao H, Hu H.   +11 more
europepmc   +4 more sources

SFMetaDB: a comprehensive annotation of mouse RNA splicing factor RNA-Seq datasets [PDF]

Database, 2017
Abstract Although the number of RNA-Seq datasets deposited publicly has increased over the past few years, incomplete annotation of the associated metadata limits their potential use. Because of the importance of RNA splicing in diseases and biological processes, we constructed a database called SFMetaDB by curating datasets related ...
Jin Li, Ching-San Tseng, Antonio Federico, Franjo Ivankovic, Yi-Shuian Huang, Alfredo Ciccodicola, Maurice S. Swanson, Peng Yu   +7 more
openaire   +2 more sources

Integrated analysis of a compendium of RNA-Seq datasets for splicing factors [PDF]

Scientific Data, 2020
Abstract A vast amount of public RNA-sequencing datasets have been generated and used widely to study transcriptome mechanisms. These data offer precious opportunity for advancing biological research in transcriptome studies such as alternative splicing.
Yu, Peng, Li, Jin, Deng, Su-Ping, Zhang, Feiran, Grozdanov, Petar N., Chin, Eunice W. M., Martin, Sheree D., Vergnes, Laurent, Islam, M. Saharul, Sun, Deqiang, LaSalle, Janine M., McGee, Sean L., Goh, Eyleen, MacDonald, Clinton C., Jin, Peng   +14 more
openaire   +4 more sources

SCR106 splicing factor modulates abiotic stress responses by maintaining RNA splicing in rice

Journal of Experimental Botany, 2023
Abstract Plants employ sophisticated molecular machinery to fine-tune their responses to growth, developmental, and stress cues. Gene expression influences plant cellular responses through regulatory processes such as transcription and splicing.
Abdulrahman Alhabsi, Haroon Butt, Gwendolyn K Kirschner, Ikram Blilou, Magdy M Mahfouz   +4 more
openaire   +3 more sources

The Interplay Between the DNA Damage Response, RNA Processing and Extracellular Vesicles

Frontiers in Oncology, 2020
RNA processing was recently found to affect DNA damage response. The RNA processing factors THRAP3 and BCLAF1 play critical role in keeping DNA genomic stability by regulating the transcription, mRNA splicing and export of DNA repair proteins BRCA2 ...
Xiangbing Meng, Xiangbing Meng, Shujie Yang, Shujie Yang, Vanessa J. A. Camp   +4 more
doaj   +1 more source