Results 31 to 40 of about 162,632 (256)

The Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing. [PDF]

PLoS Genetics, 2012
RNA splicing is a major regulatory mechanism for controlling eukaryotic gene expression. By generating various splice isoforms from a single pre-mRNA, alternative splicing plays a key role in promoting the evolving complexity of metazoans.
Long Ma, Xiaoyang Gao, Jintao Luo, Liange Huang, Yanling Teng, H Robert Horvitz   +5 more
doaj   +1 more source

Specific inhibition of splicing factor activity by decoy RNA oligonucleotides [PDF]

Nature Communications, 2019
AbstractAlternative splicing, a fundamental step in gene expression, is deregulated in many diseases. Splicing factors (SFs), which regulate this process, are up- or down regulated or mutated in several diseases including cancer. To date, there are no inhibitors that directly inhibit the activity of SFs.
Polina Denichenko, Maxim Mogilevsky, Antoine Cléry, Thomas Welte, Jakob Biran, Odelia Shimshon, Georgina D. Barnabas, Miri Danan-Gotthold, Saran Kumar, Eylon Yavin, Erez Y. Levanon, Frédéric H. Allain, Tamar Geiger, Gil Levkowitz, Rotem Karni   +14 more
openaire   +5 more sources

Identification of an RNA Binding Specificity for the Potential Splicing Factor TLS [PDF]

Journal of Biological Chemistry, 2001
The TLS/FUS gene is involved in a recurrent chromosomal translocation in human myxoid liposarcomas. We previously reported that TLS is a potential splicing regulator able to modulate the 5'-splice site selection in an E1A pre-mRNA. Using an in vitro selection procedure, we investigated whether TLS exhibits a specificity with regard to RNA recognition ...
A, Lerga, M, Hallier, L, Delva, C, Orvain, I, Gallais, J, Marie, F, Moreau-Gachelin   +6 more
openaire   +2 more sources

Pre-mRNA Splicing in Plants: In Vivo Functions of RNA-Binding Proteins Implicated in the Splicing Process

Biomolecules, 2015
Alternative pre-messenger RNA splicing in higher plants emerges as an important layer of regulation upon exposure to exogenous and endogenous cues. Accordingly, mutants defective in RNA-binding proteins predicted to function in the splicing process show ...
Katja Meyer, Tino Koester, Dorothee Staiger   +2 more
doaj   +1 more source

Interaction of hnRNPA1/A2 and DAZAP1 with an Alu-derived intronic splicing enhancer regulates ATM aberrant splicing. [PDF]

PLoS ONE, 2011
We have previously identified an Alu-derived Intronic Splicing enhancer (ISE) in the Ataxia Teleangectasia Mutated gene (ATM) that facilitates intron pre-mRNA processing and leads to the inclusion of a cryptic exon in the final mRNA transcript.
Tibor Pastor, Franco Pagani
doaj   +1 more source

L4-33K, an Adenovirus-encoded Alternative RNA Splicing Factor [PDF]

Journal of Biological Chemistry, 2006
Splicing of the adenovirus IIIa mRNA is subjected to a strict temporal regulation during virus infection such that efficient IIIa 3' splice site usage is confined to the late phase of the infectious cycle. Here we show that the adenovirus L4-33K protein functions as a virus-encoded RNA splicing factor that preferentially activates splicing of ...
Heidi, Törmänen, Ellenor, Backström, Anette, Carlsson, Göran, Akusjärvi   +3 more
openaire   +2 more sources

Role of the Constitutive Splicing Factors U2AF65 and SAP49 in Suboptimal RNA Splicing of Novel Retroviral Mutants [PDF]

Journal of Biological Chemistry, 1998
Retroviruses display a unique form of alternative splicing in which both spliced and unspliced RNAs accumulate in the cytoplasm. Simple retroviruses, such as avian sarcoma virus, do not encode regulatory proteins that affect splicing; this process is controlled solely through interactions between the viral RNA and the host cell splicing machinery ...
J, Bouck, X D, Fu, A M, Skalka, R A, Katz   +3 more
openaire   +2 more sources

TET dioxygenases localize at splicing speckles and promote RNA splicing

Nucleus
The dynamic regulation of RNA metabolism plays a crucial part in cellular function, with emerging evidence suggesting an important role for RNA modifications in this process.
Florian D. Hastert, Jasmin Weber, Christina Bauer, Andreas Zhadan, Deepanshu N. D. Singh, Thomas C. Dix, Roland Arnold, Sergey Bessonov, Matthias Soller, Heinrich Leonhardt, M. Cristina Cardoso, Maria Arroyo   +11 more
doaj   +1 more source

Dual function of SF3B2 on chromatin and RNA to regulate transcription in head and neck squamous cell carcinoma

Cell & Bioscience, 2022
RNA is spliced concomitantly with transcription and the process is organized by RNA splicing factors, transcriptional regulators, and chromatin regulators. RNA is spliced in close proximity to transcription machinery. Hence, some RNA splicing factors may
Koji Kitamura, Hidefumi Suzuki, Ryota Abe, Hidenori Inohara, Yasufumi Kaneda, Hidehisa Takahashi, Keisuke Nimura   +6 more
doaj   +1 more source

The neuronal splicing factor Nova co-localizes with target RNAs in the dendrite [PDF]

Frontiers in Neural Circuits, 2010
Nova proteins are neuron-specific RNA binding proteins targeted by autoantibodies in a disorder manifest by failure of motor inhibition, and they regulate splicing and alternative 3' processing. Nova regulates splicing of RNAs encoding synaptic proteins, including the inhibitory glycine receptor alpha2 subunit (GlyRalpha2), and binds to others ...
Claudia Racca, Claudia Racca, Alejandra Gardiol, Alejandra Gardiol, Taesun Eom, Jernej Ule, Jernej Ule, Antoine Triller, Robert B Darnell   +8 more
openaire   +4 more sources