Results 61 to 70 of about 215,019 (165)

A Drosophila model to study retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8

Disease Models & Mechanisms, 2020
Retinitis pigmentosa (RP) represents genetically heterogeneous and clinically variable disease characterized by progressive degeneration of photoreceptors resulting in a gradual loss of vision.
Dimitrije Stanković, Ann-Katrin Claudius, Thomas Schertel, Tina Bresser, Mirka Uhlirova   +4 more
doaj   +1 more source

Co-regulation of alternative splicing by diverse splicing factors in Caenorhabditis elegans [PDF]

Nucleic Acids Research, 2010
Regulation of alternative splicing is controlled by pre-mRNA sequences (cis-elements) and trans-acting protein factors that bind them. The combinatorial interactions of multiple protein factors with the cis-elements surrounding a given alternative splicing event lead to an integrated splicing decision.
Sergio Barberan-Soler, Pedro Medina, Jeffrey Estella, James Williams 0004, Alan M. Zahler   +4 more
openaire   +2 more sources

N6-Methyladenosine-related alternative splicing events play a role in bladder cancer

Open Life Sciences, 2022
This study investigated the role of N6-methyladenosine (m6A) and alternative splicing (AS) in bladder cancer (BLCA). The BLCA-related RNA expression profiles and AS events were downloaded from the UCSC Xena and SpliceSeq databases, respectively ...
Chang Yuan, Yu Shukun, Zhang Miao, Zhu Xiuyun, Jiang Tianshu, Liu Yuan   +5 more
doaj   +1 more source

H3K36 Methylation and the Chromodomain Protein Eaf3 Are Required for Proper Cotranscriptional Spliceosome Assembly

Cell Reports, 2019
Summary: In the eukaryotic cell, spliceosomes assemble onto pre-mRNA cotranscriptionally. Spliceosome assembly takes place in the context of the chromatin environment, suggesting that the state of the chromatin may affect splicing.
Calvin S. Leung, Stephen M. Douglass, Marco Morselli, Matthew B. Obusan, Marat S. Pavlyukov, Matteo Pellegrini, Tracy L. Johnson   +6 more
doaj   +1 more source

Development of a Nomogram With Alternative Splicing Signatures for Predicting the Prognosis of Glioblastoma: A Study Based on Large-Scale Sequencing Data

Frontiers in Oncology, 2020
Purpose: Alternative splicing (AS) was reported to play a vital role in development and progression of glioblastoma (GBM), the most common and fatal brain tumor. Systematic analysis of survival-associated AS event profiles and prognostic prediction model
Zihao Wang, Zihao Wang, Lu Gao, Lu Gao, Xiaopeng Guo, Xiaopeng Guo, Chenzhe Feng, Chenzhe Feng, Wei Lian, Wei Lian, Kan Deng, Kan Deng, Bing Xing, Bing Xing   +13 more
doaj   +1 more source

Genome-Wide Profiling of Alternative Splicing Signature Reveals Prognostic Predictor for Esophageal Carcinoma

Frontiers in Genetics, 2020
BackgroundAlternative splicing (AS) is a molecular event that drives protein diversity through the generation of multiple mRNA isoforms. Growing evidence demonstrates that dysregulation of AS is associated with tumorigenesis.
Jian-Rong Sun, Jian-Rong Sun, Chen-Fan Kong, Chen-Fan Kong, Yan-Ni Lou, Ran Yu, Ran Yu, Xiang-Ke Qu, Xiang-Ke Qu, Li-Qun Jia   +9 more
doaj   +1 more source

CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing

Nature Communications, 2017
U1 snRNP is critical for 5′ splicing site recognition in pre-mRNA splicing. Here the authors describe the cryo-EM structure of the yeast U1 snRNP and suggest that PrpF39 is an alternative splicing factor essential for the successful recruitment of U1 ...
Xueni Li, Shiheng Liu, Jiansen Jiang, Lingdi Zhang, Sara Espinosa, Ryan C. Hill, Kirk C. Hansen, Z. Hong Zhou, Rui Zhao   +8 more
doaj   +1 more source

CWC22 Connects Pre-mRNA Splicing and Exon Junction Complex Assembly

Cell Reports, 2012
The exon junction complex (EJC) is a key regulator of posttranscriptional mRNA fate and binds to mRNA during splicing. Although the composition of EJCs is well understood, the mechanism mediating splicing-dependent EJC assembly and the factor(s ...
Anna-Lena Steckelberg, Volker Boehm, Agnieszka M. Gromadzka, Niels H. Gehring   +3 more
doaj   +1 more source

Spliceosomic dysregulation in pancreatic cancer uncovers splicing factors PRPF8 and RBMX as novel candidate actionable targets

Molecular Oncology
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, characterized by late diagnosis and poor treatment response. Surgery is the only curative approach, only available to early‐diagnosed patients.
Emilia Alors‐Pérez, Ricardo Blázquez‐Encinas, María Trinidad Moreno‐Montilla, Víctor García‐Vioque, Juan Manuel Jiménez‐Vacas, Andrea Mafficini, Iranzu González‐Borja, Claudio Luchini, Juan M. Sánchez‐Hidalgo, Marina E. Sánchez‐Frías, Sergio Pedraza‐Arevalo, Antonio Romero‐Ruiz, Rita T. Lawlor, Antonio Viúdez, Manuel D. Gahete, Aldo Scarpa, Álvaro Arjona‐Sánchez, Raúl M. Luque, Alejandro Ibáñez‐Costa, Justo P. Castaño   +19 more
doaj   +1 more source

PTBP1 Regulates DNMT3B Alternative Splicing by Interacting With RALY to Enhance the Radioresistance of Prostate Cancer

Advanced Science
Radiotherapy is a curative arsenal for prostate cancer (PCa), but radioresistance seriously compromises its effectiveness. Dysregulated RNA splicing factors are extensively involved in tumor progression.
Haixia He, Qianghua Zhou, Yangjie Zhang, Yi Li, Lin Ding, Ting Shen, Sen Liu, Shengmeng Peng, Ming Huang, Hua Zhou, Liang Cheng, Ruihui Xie, Qiang Zhang, Junlin Lu, Liting Li, Jing Yang, Shoumin Bai, Tianxin Lin, Xu Chen   +18 more
doaj   +1 more source