Results 51 to 60 of about 215,019 (165)

RNPS1 in PSAP complex controls periodic pre-mRNA splicing over the cell cycle

iScience
Summary: Cell cycle progression requires periodic gene expression through splicing control. However, the splicing factor that directly controls this cell cycle-dependent splicing remains unknown.
Kazuhiro Fukumura, Akio Masuda, Jun-ichi Takeda, Osamu Nagano, Hideyuki Saya, Kinji Ohno, Akila Mayeda   +6 more
doaj   +1 more source

hnRNP A1 in RNA metabolism regulation and as a potential therapeutic target

Frontiers in Pharmacology, 2022
Abnormal RNA metabolism, regulated by various RNA binding proteins, can have functional consequences for multiple diseases. Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is an important RNA binding protein, that regulates various RNA metabolic ...
Jianguo Feng, Jianguo Feng, Jianguo Feng, Jianlong Zhou, Jianlong Zhou, Yunxiao Lin, Wenhua Huang, Wenhua Huang   +7 more
doaj   +1 more source

Splicing Site Recognition by Synergy of Three Domains in Splicing Factor RBM10 [PDF]

Biochemistry, 2018
Splicing factor RBM10 and its close homologues RBM5 and RBM6 govern the splicing of oncogenes such as Fas, NUMB, and Bcl-X. The molecular architecture of these proteins includes zinc fingers (ZnFs) and RNA recognition motifs (RRMs). Three of these domains in RBM10 that constitute the RNA binding part of this splicing factor were found to individually ...
Pedro Serrano, John A. Hammond, Michael Geralt, Kurt Wüthrich   +3 more
openaire   +2 more sources

MeCP2 regulates Tet1-catalyzed demethylation, CTCF binding, and learning-dependent alternative splicing of the BDNF gene in Turtle

eLife, 2017
MECP2 mutations underlying Rett syndrome cause widespread misregulation of gene expression. Functions for MeCP2 other than transcriptional are not well understood.
Zhaoqing Zheng, Ganesh Ambigapathy, Joyce Keifer   +2 more
doaj   +1 more source

Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors [PDF]

The Journal of cell biology, 1994
We have examined the functional significance of the organization of pre-mRNA splicing factors in a speckled distribution in the mammalian cell nucleus. Upon microinjection into living cells of oligonucleotides or antibodies that inhibit pre-mRNA splicing in vitro, we observed major changes in the organization of splicing factors in vivo. Interchromatin
O'Keefe, Raymond T.; id_orcid 0000-0001-8764-1289, Mayeda, Akila, Sadowski, Cynthia L., Krainer, Adrian R., Spector, David L.   +4 more
openaire   +2 more sources

Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence

BMC Cell Biology, 2017
Background Altered expression of mRNA splicing factors occurs with ageing in vivo and is thought to be an ageing mechanism. The accumulation of senescent cells also occurs in vivo with advancing age and causes much degenerative age-related pathology ...
Eva Latorre, Vishal C. Birar, Angela N. Sheerin, J. Charles C. Jeynes, Amy Hooper, Helen R. Dawe, David Melzer, Lynne S. Cox, Richard G. A. Faragher, Elizabeth L. Ostler, Lorna W. Harries   +10 more
doaj   +1 more source

Splicing factor SRSF6 mediates pleural fibrosis

JCI Insight, 2021
Pleural fibrosis is defined as an excessive deposition of extracellular matrix that results in destruction of the normal pleural tissue architecture and compromised function.
Li-Mei Liang, Liang Xiong, Pei-Pei Cheng, Shuai-Jun Chen, Xiao Feng, Ya-Ya Zhou, Qian Niu, Meng Wang, Qianlan Chen, Lin-Jie Song, Fan Yu, Xin-Liang He, Fei Xiang, Xiaorong Wang, Hong Ye, Wan-Li Ma   +15 more
doaj   +1 more source

Systematic Profiling of Alternative Splicing Events in Ovarian Cancer

Frontiers in Oncology, 2021
Alternative splicing (AS) is significantly related to the development of tumor and the clinical outcome of patients. In this study, our aim was to systematically analyze the survival-related AS signal in ovarian serous cystadenocarcinoma (OV) and ...
Jia Liu, Dekang Lv, Xiaobin Wang, Ruicong Wang, Xiaodong Li   +4 more
doaj   +1 more source

The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations

RNA Biology, 2023
The process of alternative splicing (AS) is widely deregulated in a variety of cancers. Splicing is dependent upon splicing factors. Recently, several long noncoding RNAs (lncRNAs) have been shown to regulate AS by directly/indirectly interacting with splicing factors.
Pushkar Malakar, Sudhanshu Shukla, Meghna Mondal, Rajesh Kumar Kar, Jawed Akhtar Siddiqui   +4 more
openaire   +3 more sources

PHD finger protein 5A promoted lung adenocarcinoma progression via alternative splicing

Cancer Medicine, 2019
Alternative splicing (AS) and the regulation of AS by splicing factors play critical roles in cancer. Plant homeodomain (PHD)–finger domain protein PHF5A, a critical splicing factor involved in AS, has been demonstrated to play an oncogenic role in ...
Shuangshuang Mao, Yuan Li, Zhiliang Lu, Yun Che, Jianbing Huang, Yuanyuan Lei, Yalong Wang, Chengming Liu, Xinfeng Wang, Sufei Zheng, Nan Sun, Jie He   +11 more
doaj   +1 more source