Results 51 to 60 of about 225,555 (308)

The emerging role of splicing factors in cancer [PDF]

EMBO reports, 2008
Recent progress in global sequence and microarray data analysis has revealed the increasing complexity of the human transcriptome. Alternative splicing generates a huge diversity of transcript variants and disruption of splicing regulatory networks is emerging as an important contributor to various diseases, including cancer.
Ana Rita, Grosso, Sandra, Martins, Maria, Carmo-Fonseca   +2 more
openaire   +2 more sources

Splicing factors in the heart: Uncovering shared and unique targets

Journal of Molecular and Cellular Cardiology, 2023
Alternative splicing generates specialized protein isoforms that allow the heart to adapt during development and disease. The recent discovery that mutations in the splicing factor RNA-binding protein 20 (RBM20) cause a severe form of familial dilated cardiomyopathy has sparked a great interest in alternative splicing in the field of cardiology.
Montañés-Agudo, Pablo, Pinto, Yigal M., Creemers, Esther E.   +2 more
openaire   +2 more sources

A novel Splicing Factor that Affects Titin Alternative Splicing [PDF]

Biophysical Journal, 2011
Cardiac muscle expresses predominantly larger N2BA titin isoforms at embryonic and prenatal stages of development, and these are mostly replaced with a smaller N2B isoform in adults. We have previously discovered a mutation in rats that dramatically alters titin splicing (Greaser et al J Mol Cell Cardiol 44:982, 2008).
Guo, Wei, Greaser, Marion, Li, Shijun, Schulz, Herbert, Saar, Kathrin, Radke, Michael, Hacker, Timothy A., Saupe, Kurt W., Vakeel, Padmanabhan, Govindarajan, Thirupugal, Hubner, Norbert, Gotthardt, Michael   +11 more
openaire   +1 more source

Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells. [PDF]

PLoS ONE, 2011
Alternative splicing involves differential exon selection of a gene transcript to generate mRNA and protein isoforms with structural and functional diversity.
Jan-Gowth Chang, Den-Mei Yang, Wen-Hsin Chang, Lu-Ping Chow, Wen-Ling Chan, Hui-Hua Lin, Hsien-Da Huang, Ya-Sian Chang, Cheng-Hao Hung, Wen-Kuang Yang   +9 more
doaj   +1 more source

Functional coordination of alternative splicing in the mammalian central nervous system [PDF]

, 2007
BACKGROUND: Alternative splicing (AS) functions to expand proteomic complexity and plays numerous important roles in gene regulation. However, the extent to which AS coordinates functions in a cell and tissue type specific manner is not known.
Saltzman, A.L., Rozenhek, A., Christine Misquitta, Ofer Shai, Frey, B.J., Blencowe, B.J., Babak, T., Aviad Rozenhek, Misquitta, C., Mohammad, N., Zhang, W., Brendan J Frey, Lee, L., Arneet L Saltzman, Timothy R Hughes, Willaime-Morawek, S., Qun Pan, Leo Lee, Derek van der Kooy, Barash, Y., Wen Zhang, Yoseph Barash, Joanna Y Ip, Benjamin J Blencowe, Pan, Q., Matthew Fagnani, Sandrine Willaime-Morawek, van der Kooy, D., Naveed Mohammad, Fagnani, M., Shai, O., Hughes, T.R., Tomas Babak   +32 more
core   +1 more source

Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas.

The EMBO journal, 2011
In tumours, aberrant splicing generates variants that contribute to multiple aspects of tumour establishment, progression and maintenance. We show that in glioblastoma multiforme (GBM) specimens, death-domain adaptor protein Insuloma-Glucagonoma protein 20 (IG20) is consistently aberrantly spliced to generate an antagonist, anti-apoptotic isoform (MAP ...
LeFave, Clare V, Squatrito, Massimo, Vorlova, Sandra, Rocco, Gina L, Brennan, Cameron W, Holland, Eric C, Pan, Ying-Xian, Cartegni, Luca   +7 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Alterations of RNA splicing patterns in esophagus squamous cell carcinoma

Cell & Bioscience, 2021
Alternative splicing (AS) is an important biological process for regulating the expression of various isoforms from a single gene and thus to promote proteome diversity.
Jiyu Ding, Chunquan Li, Yinwei Cheng, Zepeng Du, Qiuyu Wang, Zhidong Tang, Chao Song, Qiaoxi Xia, Wenjing Bai, Ling Lin, Wei Liu, Liyan Xu, Enmin Li, Bingli Wu   +13 more
doaj   +1 more source

Hypoxia-induced alternative splicing in endothelial cells

, 2012
Background: Adaptation to low oxygen by changing gene expression is vitally important for cell survival and tissue development. The sprouting of new blood vessels, initiated from endothelial cells, restores the oxygen supply of ischemic tissues.
Weigand, Julia E., Julia E. Weigand (17017), Julia E Weigand, Pascal Gellert, Stefanie Dimmeler, Dimmeler, Stefanie, Jes-Niels Boeckel (145707), Pascal Gellert (145710), Gellert, Pascal, Jes-Niels Boeckel, Stefanie Dimmeler (134234), Boeckel, Jes-Niels   +11 more
core   +1 more source

Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 nuclear bodies [PDF]

, 2009
Background: Active pre-mRNA splicing occurs co-transcriptionally, and takes place throughout the nucleoplasm of eukaryotic cells. Splicing decisions are controlled by networks of nuclear RNA-binding proteins and their target sequences, sometimes in ...
Rajan, P., Heiner, M., Leung, Hing, Dalgliesh, C., Bindereif, A, David J Elliott, Dalgliesh, C, Craig N Robson, Dalgliesh Caroline, Elliott, David, Kaveh Emami, Bindereif, A., Heiner Monika, Emami, K, Clark, E.L., Hing Y Leung, Elliott, D.J., Elliott, DJ, Rajan, Prabhakar, Leung Hing Y, Heiner, M, Bourgeois, C.F., Rajan, P, Prabhakar Rajan, Emami, K., Leung, H.Y., Elliott David J, Stevenin James, Stevenin, J., Clark Emma L, Emami, Kaveh, Bindereif, Albrecht, Bourgeois, CF, Bindereif Albrecht, Cyril F Bourgeois, Robson, C.N., Bourgeois, Cyril F, Prabhakar Rajan, Albrecht Bindereif, Heiner, Monika, Caroline Dalgliesh, Robson Craig N, Robson, Craig, Emma L Clark, Clark, EL, Dalgliesh, Caroline, Stevenin, J, Leung, HY, Stevenin, James, Robson, CN, Rajan Prabhakar, Bourgeois Cyril F, Emami Kaveh, Monika Heiner, James Stevenin, Clark, Emma   +55 more
core   +1 more source