Results 51 to 60 of about 369,265 (299)

The Caenorhabditis elegans Gene mfap-1 Encodes a Nuclear Protein That Affects Alternative Splicing [PDF]

, 2012
RNA splicing is a major regulatory mechanism for controlling eukaryotic gene expression. By generating various splice isoforms from a single pre–mRNA, alternative splicing plays a key role in promoting the evolving complexity of metazoans.
A Casrouge, Andrew D. Chisholm, AR Krainer, B Rutz, CC Mello, CS Hoffman, CT Chien, DA Zorio, DS Andersen, EM Makarov, ER Sawin, G Tanackovic, GS Wang, H. Robert Horvitz, HD Madhani, I Greenwald, IP de la Cruz, IS Greenwald, J Koehn, J Rappsilber, JA Pleiss, JF Rual, Jintao Luo, JZ Levin, JZ Levin, K Tabeta, K Vincent, KS McKim, L Ma, L Ma, L Merendino, L Timmons, Liange Huang, Long Ma, M Blanchette, ML Edgley, MM Brinkmann, MS Jurica, N Abovich, PD Zamore, R Reed, RS Kamath, S Arning, S Blanton, S Brenner, S Fields, S Guth, S Wu, SK Horrigan, SR Wicks, T Maniatis, TA Cooper, TW Nilsen, Xiaoyang Gao, Yanling Teng, YM Kim, Z Zhou   +56 more
core   +3 more sources

Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules [PDF]

Nature Structural & Molecular Biology, 2012
SummaryMost human genes produce multiple splicing isoforms with distinct functions. To systematically understand splicing regulation, we conducted an unbiased screen and identified >100 intronic splicing enhancers (ISEs) that were clustered by sequence similarity into six groups.
Wang, Yang, Ma, Meng, Xiao, Xinshu, Wang, Zefeng   +3 more
openaire   +2 more sources

Aurora kinase A regulates cancer-associated RNA aberrant splicing in breast cancer

Heliyon, 2023
The contribution of oncogenes to tumor-associated RNA splicing and the relevant molecular mechanisms therein require further elaboration. Here, we show that oncogenic Aurora kinase A (AURKA) promotes breast cancer-related RNA aberrant splicing in a ...
Sisi Li, Yangfan Qi, Jiachuan Yu, Yuchao Hao, Lingzhi Xu, Xudong Ding, Minghui Zhang, Jingshu Geng   +7 more
doaj   +1 more source

Transcriptomic analysis of autistic brain reveals convergent molecular pathology. [PDF]

, 2011
Autism spectrum disorder (ASD) is a common, highly heritable neurodevelopmental condition characterized by marked genetic heterogeneity. Thus, a fundamental question is whether autism represents an aetiologically heterogeneous disorder in which the ...
Blencowe, Benjamin J, Cantor, Rita M, Geschwind, Daniel H, Horvath, Steve, Johnston, Patrick, Lowe, Jennifer K, Mill, Jonathan, Tian, Yuan, Voineagu, Irina, Wang, Xinchen   +9 more
core   +3 more sources

A novel Splicing Factor that Affects Titin Alternative Splicing [PDF]

Biophysical Journal, 2011
Cardiac muscle expresses predominantly larger N2BA titin isoforms at embryonic and prenatal stages of development, and these are mostly replaced with a smaller N2B isoform in adults. We have previously discovered a mutation in rats that dramatically alters titin splicing (Greaser et al J Mol Cell Cardiol 44:982, 2008).
Guo, Wei, Greaser, Marion, Li, Shijun, Schulz, Herbert, Saar, Kathrin, Radke, Michael, Hacker, Timothy A., Saupe, Kurt W., Vakeel, Padmanabhan, Govindarajan, Thirupugal, Hubner, Norbert, Gotthardt, Michael   +11 more
openaire   +1 more source

Mud2 functions in transcription by recruiting the Prp19 and TREX complexes to transcribed genes [PDF]

, 2007
The different steps of gene expression are intimately linked to coordinate and regulate this complex process. During transcription, numerous RNA-binding proteins are already loaded onto the nascent mRNA and package the mRNA into a messenger ...
Andersen, Ulrik L., Corney, Joel F., Dong, Rui-Fang, Drummond, P. D., Elser, Dominique, Heersink, Joel, Huck, Alexander, Leuchs, G., Milanovic, Josip   +8 more
core   +1 more source

Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas.

The EMBO journal, 2011
In tumours, aberrant splicing generates variants that contribute to multiple aspects of tumour establishment, progression and maintenance. We show that in glioblastoma multiforme (GBM) specimens, death-domain adaptor protein Insuloma-Glucagonoma protein 20 (IG20) is consistently aberrantly spliced to generate an antagonist, anti-apoptotic isoform (MAP ...
LeFave, Clare V, Squatrito, Massimo, Vorlova, Sandra, Rocco, Gina L, Brennan, Cameron W, Holland, Eric C, Pan, Ying-Xian, Cartegni, Luca   +7 more
openaire   +2 more sources

Aurora-A phosphorylates splicing factors and regulates alternative splicing [PDF]

, 2020
ABSTRACTAurora-A kinase is well known to regulate progression through mitosis. However, the kinase also performs additional functions that could explain the failure of its inhibitors to be effective in cancer treatments. To identify these functions, we applied a proteomics approach to search for interactors of Aurora-A.
Arun Prasath Damodaran, Olivia Gavard, Jean-Philippe Gagné, Malgorzata Ewa Rogalska, Estefania Mancini, Thibault Courtheoux, Justine Cailloce, Agnès Mereau, Guy G. Poirier, Juan Valcárcel, Erwan Watrin, Claude Prigent   +11 more
openaire   +1 more source

Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells. [PDF]

PLoS ONE, 2011
Alternative splicing involves differential exon selection of a gene transcript to generate mRNA and protein isoforms with structural and functional diversity.
Jan-Gowth Chang, Den-Mei Yang, Wen-Hsin Chang, Lu-Ping Chow, Wen-Ling Chan, Hui-Hua Lin, Hsien-Da Huang, Ya-Sian Chang, Cheng-Hao Hung, Wen-Kuang Yang   +9 more
doaj   +1 more source

Perturbation of Chromatin Structure Globally Affects Localization and Recruitment of Splicing Factors [PDF]

, 2012
Chromatin structure is an important factor in the functional coupling between transcription and mRNA processing, not only by regulating alternative splicing events, but also by contributing to exon recognition during constitutive splicing.
Kornblihtt, Alberto R., Lamond, Angus I., Llères, David, Pawellek, Andrea, Risso, Guillermo J., Schor, Ignacio E., Ule, Jernej   +6 more
core   +8 more sources