Results 71 to 80 of about 215,019 (165)

Genome-Wide Profiling Reveals the Landscape of Prognostic Alternative Splicing Signatures in Pancreatic Ductal Adenocarcinoma

Frontiers in Oncology, 2019
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive lethal malignancy. Identification of potential alternative splicing (AS) prognostic indicators and related splicing pathways for the prediction of PDAC outcomes is lacking but urgently needed.
Chengkun Yang, Qiongyuan Wu, Ketuan Huang, Xiangkun Wang, Tingdong Yu, Xiwen Liao, Jianlu Huang, Guangzhi Zhu, Yizhen Gong, Chuangye Han, Hao Su, Wei Qin, Tao Peng   +12 more
doaj   +1 more source

SNRPB promotes gastric cancer progression by regulating aberrant splicing of PUF60

Cell Death and Disease
Alternative splicing is a pivotal regulatory mechanism in cellular biology that critically influences the tumorigenesis, progression, and phenotypic diversity of cancer.
Dan Xiang, Jiaxin Yang, Miaofang Xiao, Cong Long, Yangxuan Lin, Chenchen Mao, Xin Liu, Dianfeng Mei, Wangkai Xie, Zheng Han, Chenbin Chen, Xiaoming Lin, Xian Shen, Xiangyang Xue, Tanzhou Chen   +14 more
doaj   +1 more source

Role Of SRSF3 In Aging Periodontal Ligament Stem Cells

International Dental Journal
Aim or purpose: Alternative RNA splicing generates multiple mRNA isoforms by combining different splice sites, encoding proteins with diverse functions and expanding protein expression diversity. Aging in periodontal tissues impairs their basic functions,
Liu Miaomiao, Zhu Jiaye
doaj   +1 more source

Alternative Splicing: Emerging Roles in Anti-Aging Strategies

Biomolecules
Alternative splicing plays a fundamental role in gene expression and protein complexity. Aberrant splicing impairs cell homeostasis and is closely associated with aging and cellular senescence.
Lingyue Gao, Rong Jia
doaj   +1 more source

Aberrant splicing in splicing factor mutant MDS [PDF]

Blood, 2018
openaire   +1 more source

A Unifying Mechanism for Shared Splicing Aberrations in Splicing Factor Mutant Cancers

Abstract Cancer-associated splicing factor (SF) mutations in SF3B1 , U2AF1 , and SRSF2 induce distinct changes in alternative splicing (AS).
Boddu, Prajwal C., Roy, Rahul, Hutter, Stephen, Baumgartner, Francis, Li, Wenxue, Todisco, Gabriele, Ficara, Francesca, Della Porta, Matteo Giovanni, Liu, Yansheng, Haferlach, Torsten, Pillai, Manoj M.   +10 more
openaire   +3 more sources

Outstanding Questions to Understand and Target Splicing Factor-Mutant Blood Cancers. [PDF]

Blood Cancer Discov
Maron MI, Abdel-Wahab O.
europepmc   +1 more source

Multifaceted regulatory role of proline‑ and glutamine-rich splicing factor in tumors (Review). [PDF]

Mol Med Rep
Zhang S, Li Z, Fu L.
europepmc   +1 more source

De novo variants in the splicing factor gene SF3B1 are associated with neurodevelopmental disorders. [PDF]

Nat Commun
Uguen K, Bergot T, Scott-Boyer MP, Chapalain S, Desdouets C, Commet S, Zhu C, Xu Y, Wang Y, Roscioli T, Tran-Mau-Them F, Faivre L, Maraval J, Delanne J, Denommé-Pichon AS, Vitobello A, Jost C, Planes M, Hiatt S, Wheeler P, Gonzaga-Jauregui C, Wang H, Xin B, Sency V, Kruer MC, Bakhtiari S, Sulem P, Curry C, Prescott T, Strobl-Wildemann G, Brunet T, Doco Fenzy M, Courtin T, Poirsier C, Bjørg Hammer T, Fenger CD, MacPherson M, Izumi K, Leonard J, Li D, Zackai EH, Glass IA, Ward S, Campeau PM, Borroto MCH, Le Moigno L, Van Esch H, De Waele L, Calame DG, Lupski JR, Barcia G, Peduto C, Planté-Bordeneuve P, Dupuis L, Mendoza-Londono R, Stavropoulos DJ, Gillibert-Duplantier J, Besnard T, Do Souto Ferreira L, Cogné B, Bézieau S, Droit A, Corcos L, Lippert E, Férec C, Küry S, Bernard DG.   +66 more
europepmc   +1 more source

Prognostic alternative splicing signatures in esophageal cancer reveal SF3A3 as a key oncogenic splicing factor. [PDF]

Transl Cancer Res
Mo J, Zou Y, Zhang J, Miao H, Chen D.
europepmc   +1 more source