Results 91 to 100 of about 369,265 (299)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Systematic Profiling of Alternative Splicing Events in Ovarian Cancer

Frontiers in Oncology, 2021
Alternative splicing (AS) is significantly related to the development of tumor and the clinical outcome of patients. In this study, our aim was to systematically analyze the survival-related AS signal in ovarian serous cystadenocarcinoma (OV) and ...
Jia Liu, Dekang Lv, Xiaobin Wang, Ruicong Wang, Xiaodong Li   +4 more
doaj   +1 more source

The spliceosome, a potential Achilles heel of MYC-driven tumors [PDF]

, 2015
Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome - the core splicing machinery - that are essential for malignant transformation driven by the ...
Anczukow, O., Krainer, A. R.
core   +1 more source

PHD finger protein 5A promoted lung adenocarcinoma progression via alternative splicing

Cancer Medicine, 2019
Alternative splicing (AS) and the regulation of AS by splicing factors play critical roles in cancer. Plant homeodomain (PHD)–finger domain protein PHF5A, a critical splicing factor involved in AS, has been demonstrated to play an oncogenic role in ...
Shuangshuang Mao, Yuan Li, Zhiliang Lu, Yun Che, Jianbing Huang, Yuanyuan Lei, Yalong Wang, Chengming Liu, Xinfeng Wang, Sufei Zheng, Nan Sun, Jie He   +11 more
doaj   +1 more source

USP15 regulates dynamic protein-protein interactions of the spliceosome through deubiquitination of PRP31. [PDF]

, 2017
Post-translational modifications contribute to the spliceosome dynamics by facilitating the physical rearrangements of the spliceosome. Here, we report USP15, a deubiquitinating enzyme, as a regulator of protein-protein interactions for the spliceosome ...
Das, Tanuza, Kim, Eunice EunKyeong, Kim, Eunji, Park, Jinyoung, Park, Joon Kyu, Rape, Michael, Song, Eun Joo   +6 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A Drosophila model to study retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8

Disease Models & Mechanisms, 2020
Retinitis pigmentosa (RP) represents genetically heterogeneous and clinically variable disease characterized by progressive degeneration of photoreceptors resulting in a gradual loss of vision.
Dimitrije Stanković, Ann-Katrin Claudius, Thomas Schertel, Tina Bresser, Mirka Uhlirova   +4 more
doaj   +1 more source

Large-scale identification and characterization of alternative splicing variants of human gene transcripts using 56 419 completely sequenced and manually annotated full-length cDNAs [PDF]

, 2006
We report the first genome-wide identification and characterization of alternative splicing in human gene transcripts based on analysis of the full-length cDNAs.
Jun-ichi Takeda, Yutaka Suzuki, Mitsuteru Nakao, Roberto A. Barrero, Kanako O. Koyanagi, Lihua Jin, Chie Motono, Hiroko Hata, Takao Isogai, Keiichi Nagai, Tetsuji Otsuki, Vladimir Kuryshev, Masafumi Shionyu, Kei Yura, Mitiko Go, Jean Thierry-Mieg, Danielle Thierry-Mieg, Stefan Wiemann, Nobuo Nomura, Sumio Sugano, Takashi Gojobori, Tadashi Imanishi, Gilbert, Lopez, Smith, Schmucker, Wojtowicz, Lander, Ewing, Ladd, Modrek, Lee, Stamm, Imanishi, Zhang, Wiemann, Strausberg, Ota, Ewing, Kimura, Fairbrother, Fairbrother, Nakao, Burset, Croft, Modrek, Kochiwa, Hide, Lejeune, Lev-Maor, Will, Landry, Carninci, Kim, Karin, Peters, Xing, Nakao, Scharf, Faber, Magrangeas, Akiva, Wiemann, Oyama, Modrek, Yeo   +65 more
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

N6-Methyladenosine-related alternative splicing events play a role in bladder cancer

Open Life Sciences, 2022
This study investigated the role of N6-methyladenosine (m6A) and alternative splicing (AS) in bladder cancer (BLCA). The BLCA-related RNA expression profiles and AS events were downloaded from the UCSC Xena and SpliceSeq databases, respectively ...
Chang Yuan, Yu Shukun, Zhang Miao, Zhu Xiuyun, Jiang Tianshu, Liu Yuan   +5 more
doaj   +1 more source