Results 1 to 10 of about 5,805 (197)
Phosphorylation of SF3B1 by CDK11 orchestrates spliceosome activation via SNIP1-dependent RES complex recruitment [PDF]
Nature CommunicationsSplicing Factor 3b Subunit 1 (SF3B1), a core component of the spliceosome, undergoes dynamic phosphorylation and dephosphorylation during the splicing cycle to regulate pre-mRNA splicing. Twenty-eight threonine/proline repeats are phosphorylated by CDK11
Pavla Gajdušková +14 more
doaj +2 more sources
Structure of a step II catalytically activated spliceosome from Chlamydomonas reinhardtii [PDF]
The EMBO JournalPre-mRNA splicing, a fundamental step in eukaryotic gene expression, is executed by the spliceosomes. While there is extensive knowledge of the composition and structure of spliceosomes in yeasts and humans, the structural diversity of spliceosomes in ...
Yichen Lu, Ke Liang, Xiechao Zhan
doaj +2 more sources
Nuclear Pre-snRNA Export Is an Essential Quality Assurance Mechanism for Functional Spliceosomes
Cell Reports, 2019 Summary: Removal of introns from pre-mRNAs is an essential step in eukaryotic gene expression, mediated by spliceosomes that contain snRNAs as key components. Although snRNAs are transcribed in the nucleus and function in the same compartment, all except
Heike Krebber, Thomas Lingner
exaly +3 more sources
Crosstalk between chromatin state and ATM signalling in DNA damage-induced transcription stress [PDF]
The EMBO JournalThe DNA Damage Response (DDR) is a highly regulated process that safeguards genomic integrity against DNA lesions. Increasing evidence supports a reciprocal relationship between damaged chromatin architecture and the signalling pathways that coordinate ...
Irene Salas-Armenteros +3 more
doaj +2 more sources
PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects [PDF]
Nature CommunicationsThe carboxy-terminus of the spliceosomal protein PRPF8, which regulates the RNA helicase Brr2, is a hotspot for mutations causing retinitis pigmentosa-type 13, with unclear role in human splicing and tissue-specificity mechanism.
Robert Atkinson +31 more
doaj +2 more sources
Animals, 2022 In mammals, the testis-specific serine/threonine kinase (TSSK) is essential for spermatogenesis and male fertility. TSSK4 belongs to the family of the testis-specific serine/threonine-protein kinase (TSSK), with a crucial role in spermatogenesis.
Xingdong Wang +11 more
doaj +1 more source
Frontiers in Genetics, 2021 Many eukaryotic species contain two separate molecular machineries for removing non-coding intron sequences from pre-mRNA molecules. The majority of introns (more than 99.5% in humans) are recognized and excised by the major spliceosome, which utilizes ...
Maureen V. Akinyi, Mikko J. Frilander
doaj +1 more source
The 35S U5 snRNP Is Generated from the Activated Spliceosome during In vitro Splicing. [PDF]
PLoS ONE, 2015 Primary gene transcripts of eukaryotes contain introns, which are removed during processing by splicing machinery. Biochemical studies In vitro have identified a specific pathway in which introns are recognised and spliced out. This occurs by progressive
Olga V Makarova, Evgeny M Makarov
doaj +1 more source
Frontiers in Genetics, 2020 Splicing and alternative splicing of pre-mRNA are key sources in the formation of diversity in the human proteome. These processes have a central role in the regulation of the gene expression pathway.
Naama Sebbag-Sznajder +5 more
doaj +1 more source
Agronomy, 2021 The calmodulin-binding transcription activator (CAMTA), as one of the most distinctive families of transcription factors, plays an important role in plant growth and development and in the stress response.
Rong Gao +5 more
doaj +1 more source