Results 1 to 10 of about 6,735 (249)
Animals, 2022 In mammals, the testis-specific serine/threonine kinase (TSSK) is essential for spermatogenesis and male fertility. TSSK4 belongs to the family of the testis-specific serine/threonine-protein kinase (TSSK), with a crucial role in spermatogenesis.
Xingdong Wang +11 more
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At the Intersection of Major and Minor Spliceosomes: Crosstalk Mechanisms and Their Impact on Gene Expression [PDF]
Frontiers in Genetics, 2021 Many eukaryotic species contain two separate molecular machineries for removing non-coding intron sequences from pre-mRNA molecules. The majority of introns (more than 99.5% in humans) are recognized and excised by the major spliceosome, which utilizes ...
Maureen V. Akinyi, Mikko J. Frilander
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Phosphorylation of SF3B1 by CDK11 orchestrates spliceosome activation via SNIP1-dependent RES complex recruitment [PDF]
Nature CommunicationsSplicing Factor 3b Subunit 1 (SF3B1), a core component of the spliceosome, undergoes dynamic phosphorylation and dephosphorylation during the splicing cycle to regulate pre-mRNA splicing. Twenty-eight threonine/proline repeats are phosphorylated by CDK11
Pavla Gajdušková +14 more
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Structure of a step II catalytically activated spliceosome from Chlamydomonas reinhardtii [PDF]
The EMBO JournalPre-mRNA splicing, a fundamental step in eukaryotic gene expression, is executed by the spliceosomes. While there is extensive knowledge of the composition and structure of spliceosomes in yeasts and humans, the structural diversity of spliceosomes in ...
Yichen Lu, Ke Liang, Xiechao Zhan
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Crosstalk between chromatin state and ATM signalling in DNA damage-induced transcription stress [PDF]
The EMBO JournalThe DNA Damage Response (DDR) is a highly regulated process that safeguards genomic integrity against DNA lesions. Increasing evidence supports a reciprocal relationship between damaged chromatin architecture and the signalling pathways that coordinate ...
Irene Salas-Armenteros +3 more
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Frontiers in Genetics, 2020 Splicing and alternative splicing of pre-mRNA are key sources in the formation of diversity in the human proteome. These processes have a central role in the regulation of the gene expression pathway.
Naama Sebbag-Sznajder +5 more
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The 35S U5 snRNP Is Generated from the Activated Spliceosome during In vitro Splicing. [PDF]
PLoS ONE, 2015 Primary gene transcripts of eukaryotes contain introns, which are removed during processing by splicing machinery. Biochemical studies In vitro have identified a specific pathway in which introns are recognised and spliced out. This occurs by progressive
Olga V Makarova, Evgeny M Makarov
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Agronomy, 2021 The calmodulin-binding transcription activator (CAMTA), as one of the most distinctive families of transcription factors, plays an important role in plant growth and development and in the stress response.
Rong Gao +5 more
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Structural and Functional Insights into Human Nuclear Cyclophilins
Biomolecules, 2018 The peptidyl prolyl isomerases (PPI) of the cyclophilin type are distributed throughout human cells, including eight found solely in the nucleus. Nuclear cyclophilins are involved in complexes that regulate chromatin modification, transcription, and pre ...
Caroline Rajiv, Tara L. Davis
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The minor spliceosomal protein U11/U12-31K is an RNA chaperone crucial for U12 intron splicing and the development of dicot and monocot plants. [PDF]
PLoS ONE, 2012 U12 intron-specific spliceosomes contain U11 and U12 small nuclear ribonucleoproteins and mediate the removal of U12 introns from precursor-mRNAs. Among the several proteins unique to the U12-type spliceosomes, an Arabidopsis thaliana AtU11/U12-31K ...
Kyung Jin Kwak +6 more
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