Results 31 to 40 of about 6,327 (242)
RNAtomy of the Spliceosome's heart [PDF]
The EMBO Journal, 2013 In his 1543 monumental work De humanis corpori fabrica , Andreas Vesalius used rigorous dissection practices and a mechanistic view of the organ's function to provide the first accurate anatomical description of a human heart. Guided by similar principles of meticulous structural probing and mechanistic explanatory potential, Anokhina and colleagues in
Sophie, Bonnal, Juan, Valcárcel
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RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core. [PDF]
, 2013 Although U snRNAs play essential roles in splicing, little is known about the 3D arrangement of U2, U6, and U5 snRNAs and the pre-mRNA in active spliceosomes. To elucidate their relative spatial organization and dynamic rearrangement, we examined the RNA
Hartmuth, K. +5 more
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The MUC1 extracellular domain subunit is found in nuclear speckles and associates with spliceosomes. [PDF]
PLoS ONE, 2012 MUC1 is a large transmembrane glycoprotein and oncogene expressed by epithelial cells and overexpressed and underglycosylated in cancer cells. The MUC1 cytoplasmic subunit (MUC1-C) can translocate to the nucleus and regulate gene expression.
Priyadarsini Kumar +5 more
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Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression
eLife, 2020 Minor and major spliceosomes control splicing of distinct intron types and are thought to act largely independent of one another. SR proteins are essential splicing regulators mostly connected to the major spliceosome.
Stefan Meinke +6 more
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Hepatology Communications, 2022 CircRNAs have been reported to play crucial roles in tumor progression and recurrence, showing potential as biomarkers in cancer. However, the global abundance of circRNA and their involvement in hepatocellular carcinoma (HCC) development have not been ...
Lei He +11 more
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SF3b4: A Versatile Player in Eukaryotic Cells
Frontiers in Cell and Developmental Biology, 2020 Spliceosomes are large protein-RNA complexes regulating pre-mRNA processing in eukaryotes. SF3b4 encodes a core subunit of the U2-type spliceosome, loss- or gain-of-function of which often associates with abnormal cell growth, leading to tumorigenesis ...
Feng Xiong, Sha Li, Sha Li
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Pseudouridines in spliceosomal snRNAs [PDF]
Protein & Cell, 2011 Spliceosomal RNAs are a family of small nuclear RNAs (snRNAs) that are essential for pre-mRNA splicing. All vertebrate spliceosomal snRNAs are extensively pseudouridylated after transcription. Pseudouridines in spliceosomal snRNAs are generally clustered in regions that are functionally important during splicing.
Andrew T, Yu, Junhui, Ge, Yi-Tao, Yu
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Purification and electron microscopic visualization of functional human spliceosomes
, 2002 Pre-mRNA splicing takes place in a large and highly dynamic complex known as the spliceosome. Here we report the optimization of a maltose-binding protein (MBP) affinity-purification method to isolate functional spliceosomes for electron microscopic ...
Griffith, J. +7 more
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The phosphorylation of Prp1p by Prp4p-kinase is required for the activation of pre-catalytic spliceosomes [PDF]
, 2006 Die Rolle von Prp1p und seiner Phosphorylierung durch die Prp4p-Kinase beim Aufbau und der Aktivierung von Spleißosomen wurde untersucht. Prp1p und Prp31p werden unabhängig von der Prp4p-Kinaseaktivität an prä-katalytische Komplexe gebunden, die entweder
Bottner, Claudia
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Surprisingly high number of Twintrons in vertebrates
Biology Direct, 2013 Twintrons represent a special intronic arrangement in which introns of two different types occupy the same gene position. Consequently, alternative splicing of these introns requires two different spliceosomes competing for the same RNA molecule. So far,
Janice Jessin +2 more
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