Results 31 to 40 of about 6,735 (249)
RNAtomy of the Spliceosome's heart [PDF]
The EMBO Journal, 2013 In his 1543 monumental work De humanis corpori fabrica , Andreas Vesalius used rigorous dissection practices and a mechanistic view of the organ's function to provide the first accurate anatomical description of a human heart. Guided by similar principles of meticulous structural probing and mechanistic explanatory potential, Anokhina and colleagues in
Sophie, Bonnal, Juan, Valcárcel
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The role of the neuregulins in the nucleus [PDF]
, 2022 The neuregulins (NRGs) are ligands for receptor tyrosine kinases of the ErbB family. The NRG gene family consists of four members, NRG 1- 4 encoding different isoforms due to alternative splicing.
Wang, Ming
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The MUC1 extracellular domain subunit is found in nuclear speckles and associates with spliceosomes. [PDF]
PLoS ONE, 2012 MUC1 is a large transmembrane glycoprotein and oncogene expressed by epithelial cells and overexpressed and underglycosylated in cancer cells. The MUC1 cytoplasmic subunit (MUC1-C) can translocate to the nucleus and regulate gene expression.
Priyadarsini Kumar +5 more
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RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core. [PDF]
, 2013 Although U snRNAs play essential roles in splicing, little is known about the 3D arrangement of U2, U6, and U5 snRNAs and the pre-mRNA in active spliceosomes. To elucidate their relative spatial organization and dynamic rearrangement, we examined the RNA
Hartmuth, K. +5 more
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Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression
eLife, 2020 Minor and major spliceosomes control splicing of distinct intron types and are thought to act largely independent of one another. SR proteins are essential splicing regulators mostly connected to the major spliceosome.
Stefan Meinke +6 more
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Hepatology Communications, 2022 CircRNAs have been reported to play crucial roles in tumor progression and recurrence, showing potential as biomarkers in cancer. However, the global abundance of circRNA and their involvement in hepatocellular carcinoma (HCC) development have not been ...
Lei He +11 more
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SF3b4: A Versatile Player in Eukaryotic Cells
Frontiers in Cell and Developmental Biology, 2020 Spliceosomes are large protein-RNA complexes regulating pre-mRNA processing in eukaryotes. SF3b4 encodes a core subunit of the U2-type spliceosome, loss- or gain-of-function of which often associates with abnormal cell growth, leading to tumorigenesis ...
Feng Xiong, Sha Li, Sha Li
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Challenging the spliceosome machine [PDF]
Genome Biology, 2006 Abstract Background Using cDNA copies of transcripts and corresponding genomic sequences from the Berkeley Drosophila Genome Project, a set of 24,753 donor and acceptor splice sites were computed with a scanning algorithm that tested for single nucleotide insertion, deletion and substitution ...
Weir, Michael +2 more
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Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development
iScience, 2022 Summary: ZRSR2 is a splicing factor involved in recognition of 3′-intron splice sites that is frequently mutated in myeloid malignancies and several tumors; however, the role of mutations of Zrsr2 in other tissues has not been analyzed.
Isabel Gómez-Redondo +10 more
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Structure of spliceosomal ribonucleoproteins [PDF]
F1000 Biology Reports, 2010 Splicing of the precursors of eukaryotic mRNA and some non-coding RNAs is catalyzed by the 'spliceosome', which comprises five RNA-protein complexes (small nuclear ribonucleoproteins, or snRNPs) that assemble in an ordered manner onto precursor-mRNAs. Much progress has been made in determining the gross morphology of spliceosomal assembly intermediates.
Krummel, Daniel Aaron Pomeranz +2 more
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