Results 51 to 60 of about 8,766 (233)

Pseudouridines in spliceosomal snRNAs [PDF]

Protein & Cell, 2011
Spliceosomal RNAs are a family of small nuclear RNAs (snRNAs) that are essential for pre-mRNA splicing. All vertebrate spliceosomal snRNAs are extensively pseudouridylated after transcription. Pseudouridines in spliceosomal snRNAs are generally clustered in regions that are functionally important during splicing.
Andrew T, Yu, Junhui, Ge, Yi-Tao, Yu
openaire   +2 more sources

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

RNA Processing: Wilms' tumour — the splicing connection? [PDF]

, 1995
Major isoforms of WT1 — products of the tumour suppressor gene WT1, implicated in predisposition to Wilms' tumour — may preferentially interact with splicing factors, suggesting a role for WT1 in RNA ...
Cunill, Julio, Departament d'Arquitectura i Projectes Urbans, Sector d'Urbanisme   +2 more
core   +1 more source

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells [PDF]

, 1990
SF2, an activity necessary for 5' splice site cleavage and lariat formation during pre-mRNA splicing in vitro, has been purified to near homogeneity from HeLa cells. The purest fraction contains only two related polypeptides of 33 kD.
Conway, G. C., Kozak, D., Krainer, A. R.   +2 more
core   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

TDRD6 mediates early steps of spliceosome maturation in primary spermatocytes. [PDF]

PLoS Genetics, 2017
Tudor containing protein 6 (TDRD6) is a male germ line-specific protein essential for chromatoid body (ChB) structure, elongated spermatid development and male fertility.
Müge Akpınar, Mathias Lesche, Grigorios Fanourgakis, Jun Fu, Konstantinos Anastassiadis, Andreas Dahl, Rolf Jessberger   +6 more
doaj   +1 more source

Prognostic value of PNN in prostate cancer and its correlation with therapeutic significance

Frontiers in Genetics, 2022
Prostate cancer (PCa) is the most common malignancy. New biomarkers are in demand to facilitate the management. The role of the pinin protein (encoded by PNN gene) in PCa has not been thoroughly explored yet.
Ruisong Wang, Ruisong Wang, Ruisong Wang, Ziyi Qin, Huiling Luo, Meisen Pan, Meisen Pan, Mingyao Liu, Mingyao Liu, Pinhong Yang, Pinhong Yang, Pinhong Yang, Tieliu Shi, Tieliu Shi   +13 more
doaj   +1 more source

Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing [PDF]

, 1989
Pre-mRNA splicing occurs in a macromolecular complex called the spliceosome. Efforts to isolate spliceosomes from in vitro splicing reactions have been hampered by the presence of endogenous complexes that copurify with de novo spliceosomes formed on ...
Conway, G. C., Krainer, A. R., Spector, D. L., Roberts, R. J.   +3 more
core  

Vaults. III. Vault ribonucleoprotein particles open into flower-like structures with octagonal symmetry. [PDF]

, 1991
The structure of rat liver vault ribonucleoprotein particles was examined using several different staining techniques in conjunction with EM and digestion with hydrolytic enzymes.
Chugani, DC, Heuser, JE, Kedersha, NL, Rome, LH   +3 more
core   +2 more sources