Results 1 to 10 of about 34,718 (253)
Minor spliceosome and disease [PDF]
Seminars in Cell and Developmental Biology, 2018 The U12-dependent (minor) spliceosome excises a rare group of introns that are characterized by a highly conserved 5' splice site and branch point sequence. Several new congenital or somatic diseases have recently been associated with mutations in components of the minor spliceosome.
Maureen V Akinyi +2 more
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Structures of the human pre-catalytic spliceosome and its precursor spliceosome [PDF]
Cell Research, 2018 The pre-catalytic spliceosome (B complex) is preceded by its precursor spliceosome (pre-B complex) and followed by the activated spliceosome (Bact complex). The pre-B-to-B and B-to-Bact transitions are driven by the ATPase/helicases Prp28 and Brr2, respectively. In this study, we report the cryo-electron microscopy structures of the human pre-B complex
Xiechao Zhan +2 more
exaly +3 more sources
Some of the next articles are maybe not open access.
Proceedings of the National Academy of Sciences of the United States of America, 2016
Hao Wu, Yujuan Liu, Jun Yu
exaly
Hao Wu, Yujuan Liu, Jun Yu
exaly
A Challenging Pie to Splice: Drugging the Spliceosome
Angewandte Chemie - International Edition, 2017Brian Leon +2 more
exaly
Splicing of a rare class of introns by the U12-dependent spliceosome
Biological Chemistry, 2005Cindy L Will, Reinhard Lührmann
exaly
Dramatically reduced spliceosome in Cyanidioschyzon merolae
Proceedings of the National Academy of Sciences of the United States of America, 2015Cameron J Grisdale +2 more
exaly
Spliceosome Database: a tool for tracking components of the spliceosome [PDF]
Nucleic Acids Research, 2012 The spliceosome is the extremely complex macromolecular machine responsible for pre-mRNA splicing. It assembles from five U-rich small nuclear RNAs (snRNAs) and over 200 proteins in a highly dynamic fashion. One important challenge to studying the spliceosome is simply keeping track of all these proteins, a situation further complicated by the variety ...
Cvitkovic, Ivan, Jurica, Melissa S
openaire +6 more sources
BioEssays, 1993 AbstractThe spliceosome is a large RNA‐protein complex that catalyses the removal of introns from nuclear pre‐mRNA. A wide range of biochemical and genetical studies shows that the spliceosome comprises three major RNA‐protein subunits, the U1, U2 and [U4/U6.U5] small nuclear ribonucleoprotein particles (snRNPs), and an additional group of non‐snRNP ...
Lamond, Angus I.; id_orcid
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Neurodegenerative spliceosomopathies [PDF]
Frontiers in Cell and Developmental BiologySpliceosomal syndromes are a group of disorders caused by pathogenic variants in core spliceosomal RNAs or proteins, leading to defective pre-mRNA splicing and tissue-specific disease vulnerability. Although the spliceosome is ubiquitously expressed, its
A. Mavillonio +3 more
doaj +2 more sources
Direct and indirect effects of spliceosome disruption compromise gene regulation by nonsense-mediated mRNA decay [PDF]
RNA BiologyPre-mRNA splicing, carried out in the nucleus by a large ribonucleoprotein machine known as the spliceosome, is functionally and physically coupled to the mRNA surveillance pathway in the cytoplasm called nonsense-mediated mRNA decay (NMD).
Caleb M. Embree +3 more
doaj +2 more sources