Results 11 to 20 of about 30,416 (203)
Spliceosomal immunophilins [PDF]
FEBS Letters, 2008 The spliceosome is a dynamic, macromolecular complex, which removes non‐protein‐coding introns from pre‐mRNA to form mature mRNA in a process known as splicing. This ribonucleoprotein assembly is comprised of five uridine‐rich small nuclear RNAs (snRNAs) as well as over 300 proteins.
Mesa, Annia +2 more
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Spliceosome Database: a tool for tracking components of the spliceosome [PDF]
Nucleic Acids Research, 2012 The spliceosome is the extremely complex macromolecular machine responsible for pre-mRNA splicing. It assembles from five U-rich small nuclear RNAs (snRNAs) and over 200 proteins in a highly dynamic fashion. One important challenge to studying the spliceosome is simply keeping track of all these proteins, a situation further complicated by the variety ...
Cvitkovic, Ivan, Jurica, Melissa S
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Spliceosomal snRNA Epitranscriptomics [PDF]
Frontiers in Genetics, 2021 Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cell nucleus. snRNPs participate in pre-mRNA splicing by recognizing the critical sequence elements present
Pedro Morais, Hironori Adachi, Yi-Tao Yu
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Spliceosomal intronogenesis [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Eukaryotic transcripts contain spliceosomal introns that need to be removed by pre-mRNA splicing. Although several models have been proposed to identify the mechanism of intron gain over the evolution of eukaryotes, they remain models due to a lack of experimental validation.
Sujin, Lee, Scott W, Stevens
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Cell Reports, 2022 Summary: The spliceosome is a large ribonucleoprotein complex responsible for pre-mRNA splicing and genome stability maintenance. Disruption of the spliceosome activity may lead to developmental disorders and tumorigenesis.
Gui-Xin Ruan +8 more
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Functional roles of protein splicing factors
Bioscience Reports, 2012 RNA splicing is one of the fundamental processes in gene expression in eukaryotes. Splicing of pre-mRNA is catalysed by a large ribonucleoprotein complex called the spliceosome, which consists of five small nuclear RNAs and numerous protein factors.
Hsin‑Chou Chen +1 more
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SF3b4: A Versatile Player in Eukaryotic Cells
Frontiers in Cell and Developmental Biology, 2020 Spliceosomes are large protein-RNA complexes regulating pre-mRNA processing in eukaryotes. SF3b4 encodes a core subunit of the U2-type spliceosome, loss- or gain-of-function of which often associates with abnormal cell growth, leading to tumorigenesis ...
Feng Xiong, Sha Li, Sha Li
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Crystals, 2021 Cryo-electron microscopy has greatly advanced our understanding of how the spliceosome cycles through different conformational states to conduct the chemical reactions that remove introns from pre-mRNA transcripts.
Adelaine Kwun-Wai Leung +5 more
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The Role of E6 Spliced Isoforms (E6*) in Human Papillomavirus-Induced Carcinogenesis
Viruses, 2018 Persistent infections with High Risk Human Papillomaviruses (HR-HPVs) are the main cause of cervical cancer development. The E6 and E7 oncoproteins of HR-HPVs are derived from a polycistronic pre-mRNA transcribed from an HPV early promoter.
Leslie Olmedo-Nieva +3 more
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Mutations in the splicing regulator Prp31 lead to retinal degeneration in Drosophila
Biology Open, 2021 Retinitis pigmentosa (RP) is a clinically heterogeneous disease affecting 1.6 million people worldwide. The second-largest group of genes causing autosomal dominant RP in human encodes regulators of the splicing machinery.
Sarita Hebbar +7 more
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