Results 31 to 40 of about 34,718 (253)
Mutations in the splicing regulator Prp31 lead to retinal degeneration in Drosophila
Biology Open, 2021 Retinitis pigmentosa (RP) is a clinically heterogeneous disease affecting 1.6 million people worldwide. The second-largest group of genes causing autosomal dominant RP in human encodes regulators of the splicing machinery.
Sarita Hebbar +7 more
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Alternative splicing: transcriptional regulatory network in agroforestry
Frontiers in Plant Science, 2023 Alternative splicing (AS) in plants plays a key role in regulating the expression of numerous transcripts from a single gene in a regulatory pathway. Variable concentrations of growth regulatory hormones and external stimuli trigger alternative splicing ...
Syed Sarfaraz Hussain +12 more
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An intimate view of a spliceosome component
eLife, 2015 A high-resolution structure reveals how the ribonucleoprotein particle called U1 snRNP engages with 5′ splice sites.
Timothy W Nilsen
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Frontiers in Oncology, 2022 BackgroundElevated Small Nuclear Ribonucleoprotein Polypeptide A (SNRPA) can enhance tumor cell growth and proliferation in various cancers. However, rarely studies focus on the comprehensive analysis of SNRPA in hepatocellular carcinoma (HCC ...
Youfu Zhang +7 more
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Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression
eLife, 2020 Minor and major spliceosomes control splicing of distinct intron types and are thought to act largely independent of one another. SR proteins are essential splicing regulators mostly connected to the major spliceosome.
Stefan Meinke +6 more
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The spliceosome as a transposon sensor [PDF]
RNA Biology, 2013 The ability to distinguish self from non-self nucleic acids enables eukaryotes to suppress mobile elements and maintain genome integrity. In organisms from protist to human, this function is performed by RNA silencing pathways. There have been major advances in our understanding of the RNA silencing machinery, but the mechanisms by which these pathways
Dumesic, Phillip A, Madhani, Hiten D
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eLife, 2019 A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty in older persons, but the molecular mechanisms of such decline are not understood.
Ceereena Ubaida-Mohien +10 more
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RNAtomy of the Spliceosome's heart [PDF]
The EMBO Journal, 2013 In his 1543 monumental work De humanis corpori fabrica , Andreas Vesalius used rigorous dissection practices and a mechanistic view of the organ's function to provide the first accurate anatomical description of a human heart. Guided by similar principles of meticulous structural probing and mechanistic explanatory potential, Anokhina and colleagues in
Sophie, Bonnal, Juan, Valcárcel
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Zdorovʹe Rebenka, 2022 The scientific review presents the mechanisms of action of intranuclear miRNAs, namely microRNA-mediated regulation of the non-coding RNA (ncRNA) transcriptome and alternative splicing.
A.E. Abaturov, V.L. Babуch
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Memorias do Instituto Oswaldo Cruz, 2012 Trypanosomatidae is a family of early branching eukaryotes harbouring a distinctive repertoire of gene expression strategies. Functional mature messenger RNA is generated via the trans-splicing and polyadenylation processing of constitutively transcribed
Mario Gustavo Mayer +1 more
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