Results 31 to 40 of about 37,352 (250)

Spliceosome mutations in uveal melanoma [PDF]

, 2020
Uveal melanoma (UM) is the most common primary intraocular malignancy of the eye. It has a high metastatic potential and mainly spreads to the liver. Genetics play a vital role in tumor classification and prognostication of UM metastatic disease.
Kiliç, E. (Emine), Yavuzyigitoglu, Serdar, Kiliç, Emine; id_orcid, Naus, Nicole, de Klein, Annelies, Drabarek, W. (Wojtek), Klein, A. (Annelies) de, Verdijk, Rob, Josephine Q.N. Nguyen, Eva Medico Salsench, Brosens, Erwin; id_orcid, Kiliç, Emine, Annelies de Klein, Drabarek, Wojtek, Brosens, Erwin, Brosens, E. (Erwin), Nguyen, Josephine, Robert M. Verdijk, Nicole C. Naus, Yavuzyigitoglu, S. (Serdar), Naus, N.C. (Nicole), Nguyen, J.Q.N. (Josephine Q. N.), Serdar Yavuzyigitoglu, Verdijk, R.M. (Robert), Medico Salsench, Eva, Salsench, E.M. (Eva Medico), Erwin Brosens, Emine Kiliç, Wojtek Drabarek   +28 more
core   +2 more sources

Mutations in the splicing regulator Prp31 lead to retinal degeneration in Drosophila

Biology Open, 2021
Retinitis pigmentosa (RP) is a clinically heterogeneous disease affecting 1.6 million people worldwide. The second-largest group of genes causing autosomal dominant RP in human encodes regulators of the splicing machinery.
Sarita Hebbar, Malte Lehmann, Sarah Behrens, Catrin Hälsig, Weihua Leng, Michaela Yuan, Sylke Winkler, Elisabeth Knust   +7 more
doaj   +1 more source

Mutations in the U5 snRNA result in altered splicing of subsets of pre-mRNAs and reduced stability of Prp8 [PDF]

, 2009
The U5 snRNA loop 1 aligns the 5' and 3' exons for ligation during the second step of pre-mRNA splicing. U5 is intimately associated with Prp8, which mediates pre-mRNA repositioning within the catalytic core of the spliceosome and interacts directly with
David Barrass, J., Kershaw, Christopher J., O'Keefe, Raymond T., Barrass, J. David, Beggs, Jean D., O'Keefe, Raymond T.; id_orcid   +5 more
core   +1 more source

The Role of E6 Spliced Isoforms (E6*) in Human Papillomavirus-Induced Carcinogenesis

Viruses, 2018
Persistent infections with High Risk Human Papillomaviruses (HR-HPVs) are the main cause of cervical cancer development. The E6 and E7 oncoproteins of HR-HPVs are derived from a polycistronic pre-mRNA transcribed from an HPV early promoter.
Leslie Olmedo-Nieva, J. Omar Muñoz-Bello, Adriana Contreras-Paredes, Marcela Lizano   +3 more
doaj   +1 more source

A splicing-dependent transcriptional checkpoint associated with prespliceosome formation [PDF]

, 2014
There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown.
Chathoth, Keerthi T, Webb, Shaun, Barrass, J David, Beggs, Jean D   +3 more
core   +1 more source

Alternative splicing: transcriptional regulatory network in agroforestry

Frontiers in Plant Science, 2023
Alternative splicing (AS) in plants plays a key role in regulating the expression of numerous transcripts from a single gene in a regulatory pathway. Variable concentrations of growth regulatory hormones and external stimuli trigger alternative splicing ...
Syed Sarfaraz Hussain, Syed Sarfaraz Hussain, Manzar Abbas, Sammar Abbas, Mingke Wei, Ahmed H. El-Sappah, Ahmed H. El-Sappah, Yuhan Sun, Yun Li, Arthur J. Ragauskas, Arthur J. Ragauskas, Arthur J. Ragauskas, Quanzi Li   +12 more
doaj   +1 more source

Gene Expression Profiling of U12-Type Spliceosome Mutant Drosophila Reveals Widespread Changes in Metabolic Pathways : PLoS ONE [PDF]

, 2010
Background The U12-type spliceosome is responsible for the removal of a subset of introns from eukaryotic mRNAs. U12-type introns are spliced less efficiently than normal U2-type introns, which suggests a rate-limiting role in gene expression.
Gudrun Wahlström, Mikko J. Frilander, Pessa, Heli K. J., Heino, Tapio I., Heli K. J. Pessa, Tapio I. Heino, Auvinen, Petri, Petri Auvinen, Frilander, Mikko J., Greco, Dario, Tapio I Heino, Heli K J Pessa, Mikko J Frilander, Dario Greco, Kvist, Jouni, Jouni Kvist, Wahlström, Gudrun Margareta   +16 more
core   +1 more source

Elevated Small Nuclear Ribonucleoprotein Polypeptide an Expression Correlated With Poor Prognosis and Immune Infiltrates in Patients With Hepatocellular Carcinoma

Frontiers in Oncology, 2022
BackgroundElevated Small Nuclear Ribonucleoprotein Polypeptide A (SNRPA) can enhance tumor cell growth and proliferation in various cancers. However, rarely studies focus on the comprehensive analysis of SNRPA in hepatocellular carcinoma (HCC ...
Youfu Zhang, Xuyang Wang, Huaxiang Wang, Huaxiang Wang, Yi Jiang, Yi Jiang, Zhidan Xu, Laibang Luo   +7 more
doaj   +1 more source

Isoforms of U1-70k control subunit dynamics in the human spliceosomal U1 snRNP [PDF]

, 2009
Most human protein-encoding genes contain multiple exons that are spliced together, frequently in alternative arrangements, by the spliceosome. It is established that U1 snRNP is an essential component of the spliceosome, in human consisting of RNA and ...
Nina Morgner, Hernández Helena, Makarov Evgeny M., H. Hernández (7607219), Yutaka Muto, D. P. Krummel (7607234), Helena Hernández, Carol V Robinson, O. V. Makarova (7607222), Robinson, CV, Krummel, DP, Daniel Pomeranz Krummel, Hernandez, H, Evgeny M Makarov, Makarova, OV, Y. Muto (7607231), Olga V Makarova, Robinson Carol V., E. M. Makarov (7607225), N. Morgner (7607228), Makarov, EM, Robinson, Carol, Makarova Olga V., Muto Yutaka, Krummel Daniel Pomeranz, C. V. Robinson (7607237), Morgner, N, Morgner Nina, Muto, Y   +28 more
core   +1 more source

An intimate view of a spliceosome component

eLife, 2015
A high-resolution structure reveals how the ribonucleoprotein particle called U1 snRNP engages with 5′ splice sites.
Timothy W Nilsen
doaj   +1 more source