Results 51 to 60 of about 37,352 (250)

The significant other: splicing by the minor spliceosome [PDF]

, 2013
Peer ...
Elina H. Niemelä, Bhupendra Verma, Mikko J. Frilander, Janne J. Turunen, Frilander, Mikko J., Niemela, Elina H., Verma, Bhupendra, Turunen, Janne J.   +7 more
core   +1 more source

Characterization of spliceosome assembly in cyanidioschyzon merolae. [PDF]

, 2015
Pre-mRNA splicing is the removal of intervening sequences from pre-messenger RNA in a reaction catalyzed by the spliceosome, which contains five small nuclear RNAs (snRNAs) and more than 100 proteins.

core   +1 more source

The spliceosome: a new therapeutic target in chronic myeloid leukaemia [PDF]

, 2022
RNA splicing factors are frequently altered in cancer and can act as both oncoproteins and tumour suppressors. They have been found mutated or deregulated, justifying the growing interest in the targeting of splicing catalysis, splicing regulatory ...
Guerci, Agnès, Benjamin Lebecque, Hyacinthe Johnson-Ansah, Sandrine Saugues, Johnson-Ansah, Hyacinthe, Copland, Mhairi, Mhairi Copland, Saugues, Sandrine, Berger, Juliette, Chinmay Munje, Tassin, Thomas, Thomas Tassin, Pascale Cony-Makhoul, Agnès Guerci-Bresler, Bourgne, Celine, Tchirkov, Andrei, Andrei Tchirkov, Liu, Wei, Guerci-Bresler, Agnès, Vetrie, David, Juliette Berger, Cony-Makhoul, Pascale, Celine Bourgne, Marc G. Berger, Munje, Chinmay, David Vetrie, Lebecque, Benjamin, Berger, Marc G., Wei Liu   +28 more
core   +1 more source

Direct and indirect effects of spliceosome disruption compromise gene regulation by nonsense-mediated mRNA decay

RNA Biology
Pre-mRNA splicing, carried out in the nucleus by a large ribonucleoprotein machine known as the spliceosome, is functionally and physically coupled to the mRNA surveillance pathway in the cytoplasm called nonsense-mediated mRNA decay (NMD).
Caleb M. Embree, Debadrita Paul, Andreas Stephanou, Guramrit Singh   +3 more
doaj   +1 more source

A day in the life of the spliceosome [PDF]

Nature Reviews Molecular Cell Biology, 2014
One of the most amazing findings in molecular biology was the discovery that eukaryotic genes are discontinuous, interrupted by stretches of non-coding sequence. The subsequent realization that the intervening regions are removed from pre-mRNA transcripts via the activity of a common set of small nuclear RNAs (snRNAs), which assemble together with ...
A Gregory, Matera, Zefeng, Wang
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Mutations in the U11/U12-65K protein associated with isolated growth hormone deficiency lead to structural destabilization and impaired binding of U12 snRNA [PDF]

, 2017
Mutations in the components of the minor spliceosome underlie several human diseases. A subset of patients with isolated growth hormone deficiency (IGHD) harbors mutations in the RNPC3 gene, which encodes the minor spliceosome-specific U11/U12-65K ...
Tuuli M. Kauppala, Bhupendra Verma, Mikko J. Frilander, Kauppala, Tuuli M., Antto J. Norppa, Frilander, Mikko J., Iwai, Hideo, Heikkinen, Harri A., Verma, Bhupendra, Hideo Iwaï, Norppa, Antto J., Harri A. Heikkinen   +11 more
core   +1 more source

The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction

eLife, 2016
The DEAH-box NTPase Prp43 and its cofactors Ntr1 and Ntr2 form the NTR complex and are required for disassembling intron-lariat spliceosomes (ILS) and defective earlier spliceosomes.
Jean-Baptiste Fourmann, Olexandr Dybkov, Dmitry E Agafonov, Marcel J Tauchert, Henning Urlaub, Ralf Ficner, Patrizia Fabrizio, Reinhard Lührmann   +7 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Perturbation of chromatin structure globally affects localization and recruitment of splicing factors [PDF]

, 2012
Chromatin structure is an important factor in the functional coupling between transcription and mRNA processing, not only by regulating alternative splicing events, but also by contributing to exon recognition during constitutive splicing.
Risso, Guillermo, J, Risso Guillermo J., Lleres, D, Jernej Ule, Ignacio E. Schor (120406), Llères, David, Llères David, Pawellek, A., Ule, J., Kornblihtt Alberto R., Schor, Ignacio, E, Risso, GJ, Ule, Jernej, Lamond, Angus I.; id_orcid, Lamond, A.I., Alberto R. Kornblihtt (120413), Lamond, Angus, I, Kornblihtt, Alberto, R, Pawellek, Andrea, Andrea Pawellek, Alberto R Kornblihtt, David Llères (68840), Guillermo J. Risso (120408), Andrea Pawellek (120410), Risso, Guillermo J., Schor*, I.E., Schor, I.E., Lamond Angus I., Schor, Ignacio E., Ule, J, Ule Jernej, Risso, G.J., David Llères, Kornblihtt, A.R., Ignacio E Schor, Pawellek Andrea, Lleres*, D., Lamond, AI, Guillermo J Risso, Angus I Lamond, Kornblihtt, Alberto R., Llères, D., Schor Ignacio E., Pawellek, A, Schor, IE, Angus I. Lamond (13065), Kornblihtt, AR, Jernej Ule (115588)   +47 more
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