Results 41 to 50 of about 34,718 (253)

The spliceosome inhibitors isoginkgetin and pladienolide B induce ATF3-dependent cell death.

PLoS ONE, 2020
The spliceosome assembles on pre-mRNA in a stepwise manner through five successive pre-spliceosome complexes. The spliceosome functions to remove introns from pre-mRNAs to generate mature mRNAs that encode functional proteins.
Erin J Vanzyl, Hadil Sayed, Alex B Blackmore, Kayleigh R C Rick, Pasan Fernando, Bruce C McKay   +5 more
doaj   +1 more source

Pseudouridines in spliceosomal snRNAs [PDF]

Protein & Cell, 2011
Spliceosomal RNAs are a family of small nuclear RNAs (snRNAs) that are essential for pre-mRNA splicing. All vertebrate spliceosomal snRNAs are extensively pseudouridylated after transcription. Pseudouridines in spliceosomal snRNAs are generally clustered in regions that are functionally important during splicing.
Andrew T, Yu, Junhui, Ge, Yi-Tao, Yu
openaire   +2 more sources

The spliceosome: a new therapeutic target in chronic myeloid leukaemia [PDF]

, 2022
RNA splicing factors are frequently altered in cancer and can act as both oncoproteins and tumour suppressors. They have been found mutated or deregulated, justifying the growing interest in the targeting of splicing catalysis, splicing regulatory ...
Guerci, Agnès, Benjamin Lebecque, Hyacinthe Johnson-Ansah, Sandrine Saugues, Johnson-Ansah, Hyacinthe, Copland, Mhairi, Mhairi Copland, Saugues, Sandrine, Berger, Juliette, Chinmay Munje, Tassin, Thomas, Thomas Tassin, Pascale Cony-Makhoul, Agnès Guerci-Bresler, Bourgne, Celine, Tchirkov, Andrei, Andrei Tchirkov, Liu, Wei, Guerci-Bresler, Agnès, Vetrie, David, Juliette Berger, Cony-Makhoul, Pascale, Celine Bourgne, Marc G. Berger, Munje, Chinmay, David Vetrie, Lebecque, Benjamin, Berger, Marc G., Wei Liu   +28 more
core   +1 more source

SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly

, 2005
We have isolated the human protein SNEV as downregulated in replicatively senescent cells. Sequence homology to the yeast splicing factor Prp19 suggested that SNEV might be the orthologue of Prp19 and therefore might also be involved in pre-mRNA splicing.
Grillari, Johannes, Lamond, Angus I., Stadler, Guido, Voglauer, Regina, Eisenhaber, Frank, Löscher, Marlies, Lamond, Angus I.; id_orcid, Pokar, Marion, Ajuh, Paul, Grey, Martin, Fortschegger, Klaus, Ernst, Wolfgang, Katinger, Hermann, Chusainow, Janet   +13 more
core   +1 more source

Characterization of spliceosome assembly in cyanidioschyzon merolae. [PDF]

, 2015
Pre-mRNA splicing is the removal of intervening sequences from pre-messenger RNA in a reaction catalyzed by the spliceosome, which contains five small nuclear RNAs (snRNAs) and more than 100 proteins.

core   +1 more source

Mutations in the U5 snRNA result in altered splicing of subsets of pre-mRNAs and reduced stability of Prp8

, 2009
The U5 snRNA loop 1 aligns the 5' and 3' exons for ligation during the second step of pre-mRNA splicing. U5 is intimately associated with Prp8, which mediates pre-mRNA repositioning within the catalytic core of the spliceosome and interacts directly with
David Barrass, J., Kershaw, Christopher J., O'Keefe, Raymond T., Barrass, J. David, Beggs, Jean D., O'Keefe, Raymond T.; id_orcid   +5 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Spliceosome Structure and Function [PDF]

Cold Spring Harbor Perspectives in Biology, 2010
Pre-mRNA splicing is catalyzed by the spliceosome, a multimegadalton ribonucleoprotein (RNP) complex comprised of five snRNPs and numerous proteins. Intricate RNA-RNA and RNP networks, which serve to align the reactive groups of the pre-mRNA for catalysis, are formed and repeatedly rearranged during spliceosome assembly and catalysis.
Will, C., Lührmann, R.
openaire   +3 more sources

Mutations in the U11/U12-65K protein associated with isolated growth hormone deficiency lead to structural destabilization and impaired binding of U12 snRNA [PDF]

, 2017
Mutations in the components of the minor spliceosome underlie several human diseases. A subset of patients with isolated growth hormone deficiency (IGHD) harbors mutations in the RNPC3 gene, which encodes the minor spliceosome-specific U11/U12-65K ...
Tuuli M. Kauppala, Bhupendra Verma, Mikko J. Frilander, Kauppala, Tuuli M., Antto J. Norppa, Frilander, Mikko J., Iwai, Hideo, Heikkinen, Harri A., Verma, Bhupendra, Hideo Iwaï, Norppa, Antto J., Harri A. Heikkinen   +11 more
core   +1 more source

Flow cytometric analysis identifies changes in S and M phases as novel cell cycle alterations induced by the splicing inhibitor isoginkgetin.

PLoS ONE, 2018
The spliceosome is a large ribonucleoprotein complex that catalyzes the removal of introns from RNA polymerase II-transcribed RNAs. Spliceosome assembly occurs in a stepwise manner through specific intermediates referred to as pre-spliceosome complexes E,
Erin J Vanzyl, Kayleigh R C Rick, Alex B Blackmore, Erin M MacFarlane, Bruce C McKay   +4 more
doaj   +1 more source