Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency [PDF]
mBio, 2018 The main obstacle to an HIV cure is the transcriptionally inert proviruses that persist in resting CD4 T cells and other reservoirs. None of the current approaches has significantly reduced the size of the viral reservoir.
George B. Kyei +6 more
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Precursor RNA structural patterns at SF3B1 mutation sensitive cryptic 3’ splice sites [PDF]
RNA BiologySF3B1 is a core component of the spliceosome involved in branch point recognition and 3’ splice site selection. The SF3B1 K700E mutation (lysine to glutamic acid) is common in myelodysplastic syndrome and other blood disorders.
Austin Herbert +5 more
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Journal of Hematology and Oncology, 2018 Background SF3B1 is a core component of splicing machinery. Mutations in SF3B1 are frequently found in myelodysplastic syndromes (MDS), particularly in patients with refractory anemia with ringed sideroblasts (RARS), characterized by isolated anemia ...
John Hale, Wei Li, Shijie Zhang
exaly +3 more sources
De novo variants in the splicing factor gene SF3B1 are associated with neurodevelopmental disorders [PDF]
Nature CommunicationsSF3B1 is an essential and ubiquitous splicing factor that plays a pivotal role in the early steps of pre-mRNA splicing. Recurrent somatic missense mutations in SF3B1 are frequent in cancers, but no constitutional variant has been reported so far.
Kevin Uguen +66 more
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Age, JAK2V617F and SF3B1 mutations are the main predicting factors for survival in refractory anaemia with ring sideroblasts and marked thrombocytosis [PDF]
Leukemia, 2013 Broséus, J., Alpermann, T., Wulfert, M., Florensa Brichs, L., Jeromin, S., Lippert, E., Rozman, M., Lifermann, F., Grossmann, V., Haferlach, T., Germing, U., Luño, E., Girodon, F., Schnittger ...
Alpermann, T. +9 more
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HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease [PDF]
Nature, 2015 Fructose is a major component of dietary sugar and its overconsumption exacerbates key pathological features of metabolic syndrome. The central fructose-metabolising enzyme is ketohexokinase (KHK), which exists in two isoforms: KHK-A and KHK-C, generated
Peter Mirtschink +2 more
exaly +4 more sources
Cancer-associated SF3B1 mutation suppresses DNA repair by disrupting the organization of nuclear actin network [PDF]
Cell Death and DiseaseNuclear actin filament is required for efficient repair of DNA double-strand breaks. While cancer-associated SF3B1 mutation leads to impaired DNA repair, the underlying mechanism remains elusive.
Rui Qian +8 more
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Splicing factor Sf3b1 facilitates maintenance of neuronal dendrites by modulating mitochondrial health [PDF]
Cellular and Molecular Life SciencesThe intricate process of dendritic arborization is essential for forming functional neural circuits, and many of the underlying molecular and cellular mechanisms have been uncovered.
Wei-Chia Tsao +6 more
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Silencing SF3B1 promotes apoptosis and inhibits proliferation and invasion of human lung cancer cell line A549 [PDF]
Jichu yixue yu linchuang, 2023 Objective To explore the effect of splicing factor 3B subunit (SF3B1) on apoptosis, proliferation and invasion of human lung cancer cells. Methods Non-small cell lung cancer(NSCLC) patients in the General Hospital of Western Theater Command PLA from ...
ZHANG Xiaowan, KANG Xia, YAO Xiaoying, XIE Fang, LI Ying
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Pre-mRNA splicing-associated diseases and therapies
RNA Biology, 2023 Precursor mRNA (pre-mRNA) splicing is an essential step in human gene expression and is carried out by a large macromolecular machine called the spliceosome.
Sierra L. Love +3 more
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