Results 41 to 50 of about 12,272 (217)

Prognostic correlation of NOTCH1 and SF3B1 mutations with chromosomal abnormalities in chronic lymphocytic leukemia patients

Cancer Reports, 2023
Background and Aim Chronic lymphocytic leukemia (CLL) is a monoclonal malignancy of B lymphocytes. Since common mutations in NOTCH1 and SF3B1, along with other possible chromosomal alterations, change disease severity and survival of patients with CLL ...
Reza Sadria, Nasrin Motamed, Mohammad Saberi Anvar, Hassan Mehrabani Yeganeh, Behzad Poopak   +4 more
doaj   +1 more source

The SF3B1 R625H mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1

Journal of Experimental & Clinical Cancer Research, 2022
Background Recently, a hotspot mutation in prolactinoma was observed in splicing factor 3b subunit 1 (SF3B1 R625H ), but its functional effects and underlying molecular mechanisms remain largely unexplored.
Jing Guo, Chuzhong Li, Qiuyue Fang, Yulou Liu, Dawei Wang, Yiyuan Chen, Weiyan Xie, Yazhuo Zhang   +7 more
doaj   +1 more source

Studying the connection between SF3B1 and four types of cancer by analyzing networks constructed based on published research

Scientific Reports, 2023
Splicing factor 3B subunit 1 (SF3B1) is the largest component of SF3b protein complex which is involved in the pre-mRNA splicing mechanism. Somatic mutations of SF3B1 were shown to be associated with aberrant splicing, producing abnormal transcripts that
Asmaa Samy, Mehmet Kemal Ozdemir, Reda Alhajj   +2 more
doaj   +1 more source

Comparison of SF3B1/DNMT3A Comutations With DNMT3A or SF3B1 Mutation Alone in Myelodysplastic Syndrome and Clonal Cytopenia of Undetermined Significance [PDF]

American Journal of Clinical Pathology, 2020
Abstract Objectives To compare the clinical significance of SF3B1/DNMT3A Comutations with SF3B1 or DNMT3A mutation alone in myelodysplastic syndrome (MDS) and clonal cytopenia of undetermined significance (CCUS). Methods We identified
Hailing Zhang, Lynn Moscinski, Pukhraz Basra, David Gajzer, Ling Zhang, Haipeng Shao, Xiaohui Zhang, Dahui Qin, Mohammad Hussaini, Jinming Song   +9 more
openaire   +2 more sources

Lack of SF3B1 R625 mutations in cutaneous melanoma [PDF]

Diagnostic Pathology, 2013
Abstract Background Melanoma is a deadly disease affecting people worldwide. Genetic studies have identified different melanoma subtypes characterized by specific recurrently mutated genes and led to the successful clinical introduction of targeted therapies.
Schilling, Bastian, Bielefeld, Nicola, Sucker, Antje, Hillen, Uwe, Zimmer, Lisa, Schadendorf, Dirk, Zeschnigk, Michael, Griewank, Klaus   +7 more
openaire   +2 more sources

SF3B1 is a stress-sensitive splicing factor that regulates both HSF1 concentration and activity. [PDF]

PLoS ONE, 2017
The heat shock response (HSR) is a well-conserved, cytoprotective stress response that activates the HSF1 transcription factor. During severe stress, cells inhibit mRNA splicing which also serves a cytoprotective function via inhibition of gene ...
Karen S Kim Guisbert, Eric Guisbert
doaj   +1 more source

Altered DNA Methylation Profiles in SF3B1 Mutated CLL Patients [PDF]

, 2021
Mutations in splicing factor genes have a severe impact on the survival of cancer patients. Splicing factor 3b subunit 1 (SF3B1) is one of the most frequently mutated genes in chronic lymphocytic leukemia (CLL); patients carrying these mutations have a ...
Mücke, O., Christoph Plass, Reinhardt, H.C., Anja Königs, Michal R. Schweiger, Herling, C., Bernd Timmermann, Herwig, R., Schweiger, M.R., Königs, A., Alicja Pacholewska, Pacholewska, A., Christina Grimm, Janine Altmüller, Grimm, C., Reinhardt, H., Plass, C., Ralf Herwig, Oliver Mücke, Lienhard, M., Schweiger, M., Carmen D. Herling, Altmüller, J., Hallek, M., Michael Hallek, Timmermann, B., Matthias Lienhard, Herling, C.D., Hans Christian Reinhardt   +28 more
core   +1 more source

SF3B1 and EIF1AX mutations occur in primary leptomeningeal melanocytic neoplasms; yet another similarity to uveal melanomas [PDF]

, 2016
Introduction: Like uveal melanomas, primary leptomeningeal melanocytic neoplasms (LMNs) frequently carry GNAQ and GNA11 mutations. However, it is currently unknown whether these LMNs harbor mutations in BAP1, SF3B1 and/or EIF1AX like uveal melanomas as ...
Wesseling, Pieter, Blokx, Willeke AM, Groenen, Patricia JTA, Heidi V. N. Küsters-Vandevelde, Benno Küsters, Willeke A. M. Blokx, Kusters-vandevelde, H.V., Blokx, Willeke A. M., Adriana C. H. van Engen-van Grunsven, Engen-van Grunsven, A.C.H. van, Prinsen, Clemens FM, Küsters-Vandevelde, Heidi V N, Blokx, W.A., Patricia J. T. A. Groenen, Veronique Winnepenninckx, van Engen- van Grunsven, Adriana CH, Groenen, Patricia J. T. A., Creytens, David, Jeunink, M., van Engen-van Grunsven, Adriana C H, Blokx, Willeke A M, Küsters-Vandeveld, Heidi VN, Kusters, B., Kusters-Vandevelde, Heidi V. N., Wesseling, P., Winnepenninckx, Veronique, Marcel Jeunink, David Creytens, Pieter Wesseling, Clemens F. M. Prinsen, Groenen, P.J., Creytens, D., Prinsen, Clemens F. M., Prinsen, Clemens F.M., Jeunink, Marcel, van Engen-van Grunsven, Adriana C. H., Groenen, Patricia J T A, Winnepenninckx, V., Prinsen, C.F., Küsters, Benno   +39 more
core   +3 more sources

Altered selection of branch sites by sf3b1 mutants.

, 2021
(A) Schematic graph for identification of BS by nested lariat RT-PCR and sequencing. cDNA from the intronic lariat is transcribed using an intron-specific antisense primer P1′, and then amplified by two-steps PCRs using primer sets P1′ + P1 and P2′ + P2.
Bei Zhang (428038), Zhan Ding (3799741), Yong-Zhen Xu (6428087), Ling-Kun Xie (11632092), Yu-Jie Fan (6428084), Liang Li (46069)   +5 more
core   +1 more source

SF3B1 promotes tumor malignancy through splicing-independent co-activation of HIF1α [PDF]

, 2020
Heterozygous mutations in the splicing factor SF3B1 are frequently occurring in various cancers and drive tumor progression through the activation of cryptic splice sites in multiple genes.
Cortijo, Cédric, Davidson, Natalie R, Hirt, Christian, Ringel, Till, Koch, Lisa M, Angori, Silvia, Lenggenhager, Daniela, Guccini, Ilaria, Schwank, Gerald; https://orcid.org/, Stoffel, Markus, Mirtschink, Peter, Bolck, Hella A, Pellegrini, Giovanni, Simmler, Patrik T, Pauli, Chantal, Lehmann, Kjong-Van, Galliker, Patricia, Vukolic, Ana, Moch, Holger, Rätsch, Gunnar, Mueller, Christina, Christinat, Yann   +21 more
core   +1 more source