Results 51 to 60 of about 10,998 (173)

SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes

, 2016
Whole exome/genome sequencing has been fundamental in the identification of somatic mutations in the spliceosome machinery in myelodysplastic syndromes (MDSs) and other hematologic disorders.
Koseki, Haruhiko, O'Keefe, Christine, Traina, Fabiola, Saunthararajah, Yogen, Isono, Kyoichi, Bupathi, Manoj, Osman, Sami, Koide, Kazunori, Makishima, Hideki, Barnard, John, Singh, Jarnail, Szpurka, Hadrian, Jerez, Andres, Copelan, Edward, Rogers, Heesun J., Advani, Anjali S., Tiu, Ramon V., Padgett, Richard A., Maciejewski, Jaroslaw P., Sekeres, Mikkael A., McMahon, James, Visconte, Valeria, Jankowska, Anna   +22 more
core   +2 more sources

Distinct Pattern of Atypical Megakaryocytes in VEXAS Syndrome

International Journal of Laboratory Hematology, EarlyView.
Andrew Y. Sung, Jackson W. Douglas, Olga K. Weinberg, Sharon K. Germans, Weina Chen   +4 more
wiley   +1 more source

Mutational dynamics in patients with del(5q) MDS treated with lenalidomide prior to transfusion dependency—Molecular results from the Sintrarev clinical trial

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Lenalidomide (Len) is the standard of care for red blood cell transfusion‐dependent (TD) patients with myelodysplastic syndromes (MDS) and del(5q). A Phase III clinical trial (SintraRev) demonstrated better efficacy of early treatment with Len in anemic del(5q) MDS patients prior to TD, but clonal evolution with this approach remained ...
Sofía Toribio Castelló, Felix López‐Cadenas, Claude Preudhomme, Teresa González, Angela Villaverde Ramiro, Laurène Fenwarth, Blanca Xicoy, Aline Renneville, Joaquín Sánchez‐Garcia, Rosa Coll, Bohrane Slama, José Ángel Hernández‐Rivas, Sylvain Thepot, Teresa Bernal, Agnès Guerci‐Bresler, Raúl Azibeiro, Monica Del Rey, Katharina S. Götze, Pierre Fenaux, Jesús María Hernández‐Rivas, María Díez‐Campelo   +20 more
wiley   +1 more source

Genetic alterations of SUGP1 mimic mutant-SF3B1 splice pattern in lung adenocarcinoma and other cancers

, 2020
International audienceGenes involved in 3′-splice site recognition during mRNA splicing constitute an emerging class of oncogenes. SF3B1 is the most frequently mutated splicing factor in cancer, and SF3B1 mutants corrupt branchpoint recognition leading ...
Bellanger, Dorine, Waterfall, Joshua, J, Tarin, Malcy, Roman-Roman, Sergio, Stern, Marc-Henri, Popova, Tatiana, Houy, Alexandre, Cornella, Michele, Alsafadi, Samar, Dayot, Stephane, Wassef, Michel, M., Lehnert, Erik   +11 more
core   +1 more source

Acute Myeloid Leukemia With Florid Plasmacytoid Dendritic Cell Expansion and Aberrant Expression of CD19

International Journal of Laboratory Hematology, EarlyView.
Afshin Shameli, Russell K. Dorer
wiley   +1 more source

EHA Guidelines on management of chronic lymphocytic leukemia and Richter transformation

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Previous editions of the European guidelines for the management of chronic lymphocytic leukemia (CLL) were developed by experts in CLL under the auspices of the European Society for Medical Oncology (ESMO). These previous editions have served as a reference text for many physicians caring for patients with CLL.
Barbara Eichhorst, Paolo Ghia, Francesc Bosch, Ruth Clifford, Michael Gregor, Romain Guieze, Arnon P. Kater, Carsten U. Niemann, Sarka Pospisilova, Tadeusz Robak, Anna Schuh, Kostas Stamatopoulos, Tamar Tadmor, Nick York   +13 more
wiley   +1 more source

Clinical Outcomes With Ring Sideroblasts and SF3B1 Mutations in Myelodysplastic Syndromes: MDS Clinical Research Consortium Analysis

, 2018
The World Health Organization 2016 classification of myelodysplastic syndromes (MDS) incorporates SF3B1 mutational status, in which patients with > 5% ring sideroblasts (RS) in the presence of SF3B1 mutation are classified as MDS-RS.
Steensma, David P., DeZern, Amy, John Barnard, Guillermo Garcia-Manero, Migdady, Yazan, Sekeres, Mikkael A., Najla Al Ali, Roboz, Gail, Barnard, John, Al Ali, Najla, Komrokji, Rami S., Mikkael A. Sekeres, Gail Roboz, Garcia-Manero, Guillermo, David P. Steensma, Amy DeZern, Yazan Migdady, Rami S. Komrokji   +17 more
core   +1 more source

Erythroid differentiation intensifies RNA mis-splicing inSF3B1-mutant myelodysplastic syndromes with ring sideroblasts

, 2023
Myelodysplastic syndromes with ring sideroblasts (MDS-RS) commonly originate from mutations in the splicing factor SF3B1 ( SF3B1 mt ). SF3B1 mt cause RNA mis-splicing, mechanistically established as the major driver of RS development.
Granados, D, Mortera-Blanco, T, Moura, P,, Todisco, G, Hagemann-Jensen, M,, Kretzschmar, W, Creignou, M, Ziegenhain, C, Hofman, IJF, Björklund, A-C   +9 more
core   +1 more source

Inhibition of SF3B1 phosphorylation by DYRK1A in HeLa cells.

, 2015
HeLa cells expressing GFP-SF3B1-NT were treated with the indicated compounds for 18 h. The phosphorylation state of SF3B1 was determined by immunoblotting with pT434 antibody, and the results were normalized to the total amount of SF3B1 immunoreactivity.
Agnes Walte (772754), Anne Wurzlbauer (772753), Katharina Rüben (772752), Wolfgang Sippl (169574), Franz Bracher (458039), Walter Becker (31437)   +5 more
core   +1 more source

Recurrent Genomic Alterations in BCRi‐Experienced CLL Patients Treated With Venetoclax: Extended Phase 2 Follow‐Up

American Journal of Hematology, Volume 101, Issue 7, Page 1516-1521, July 2026.
Jennifer A. Woyach, Relja Popovic, Emily L. Rossi, Sanjana Singh, Toshihiko Oki, Tanya S. Rosenberg, Chen Qian, Michael Moran, Zihuan Liu, Michelle Boyer, Jeffrey Jones, Richard R. Furman, William Wierda, Jason Gotlib, Stephen J. Schuster, Brenda Chyla, Matthew S. Davids   +16 more
wiley   +1 more source