Results 71 to 80 of about 12,272 (217)

SF3B1 homeostasis is critical for survival and therapeutic response in T cell leukemia [PDF]

, 2022
The production of noncanonical mRNA transcripts is associated with cell transformation. Driven by our previous findings on the sensitivity of T cell acute lymphoblastic leukemia (T-ALL) cells to SF3B1 inhibitors, we identified that SF3B1 inhibition ...
Politanska, Yuliya, Mattamana, Basil B., Jin, Qi, Jordan, Philip W., Obeng, Rebecca C., Sun, Limin, Pryzhkova, Marina V., Buldini, Barbara, Khodadadi-Jamayran, Alireza, Cho, Byoung-Kyu, Gutierrez-Diaz, Blanca T., Basso, Giuseppe, Velu, Sadanandan E., Zhou, Yalu, Abdala-Valencia, Hiam, Bartom, Elizabeth Thomas, Pryzhkova, Marina, Zhu, Ping, Han, Cuijuan, Serafin, Valentina, Ntziachristos, Panagiotis, Tsirigos, Aristotelis, Sarma, Kavitha, Lorch, Adam H., Ntziachristos, PanagiotisGE310002110541158020037237250000-0001-6374-89542bb55610-e038-11eb-9486-d537db485220, Goo, Young Ah   +25 more
core   +1 more source

Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency

mBio, 2018
The main obstacle to an HIV cure is the transcriptionally inert proviruses that persist in resting CD4 T cells and other reservoirs. None of the current approaches has significantly reduced the size of the viral reservoir.
George B. Kyei, Shanshan Meng, Rashmi Ramani, Austin Niu, Chandraiah Lagisetti, Thomas R. Webb, Lee Ratner   +6 more
doaj   +1 more source

Prognostic Significance of Secondary-Type Mutations in NPM1-Mutated Acute Myeloid Leukemia. [PDF]

Cancer Med
ABSTRACT NPM1 is among the most frequently mutated genes in acute myeloid leukemia (AML), and NPM1‐mutated AML is generally associated with a favorable prognosis. However, substantial prognostic heterogeneity exists within this population. The prognostic significance of secondary‐type mutations (STMs) in NPM1‐mutated AML remains controversial.
Yang K, Luo H, Xiang B, Dai Y, Gong Y, Huang J, Li J, Jia Y, Guo Y, Zheng Y, Ma H.   +10 more
europepmc   +2 more sources

Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities [PDF]

Cancer Cell, 2016
In this issue of Cancer Cell, Obeng et al. identify the consequences of expressing the most common mutation in the spliceosomal gene SF3B1 on hematopoiesis. The knockin mouse model described represents a valuable tool to dissect the effects of SF3B1 mutations on transformation, splicing, and less well-characterized functions of SF3B1.
Daichi, Inoue, Omar, Abdel-Wahab
openaire   +2 more sources

Quizartinib Resistance Mutations and Treatment Outcomes in Relapsed or Refractory FLT3‐ITD–Positive AML

Cancer Science, EarlyView.
ABSTRACT Quizartinib is a FMS‐like tyrosine kinase 3 (FLT3) inhibitor indicated for FLT3 internal tandem duplication (FLT3‐ITD)–positive acute myeloid leukemia (AML). We aimed to evaluate quizartinib resistance mechanisms, in addition to efficacy and safety outcomes, in patients with relapsed or refractory FLT3‐ITD–positive AML.
Yuichiro Semba, Toshihiro Miyamoto, Senji Kasahara, Yoshikane Kikushige, Takahiro Maeda, Goichi Yoshimoto, Shuichi Ota, Akio Saito, Yuho Najima, Hiroki Hosoi, Daigo Niiya, Koji Kato, Koji Nagafuji, Takashi Akasaka, Tomohiko Kamimura, Atsushi Takita, Maiko Narahara, Tadashi Toki, Koichi Iwanaga, Koji Yonemoto, Mine Harada, Koichi Akashi   +21 more
wiley   +1 more source

The impact of spliceosome inhibition in SF3B1-mutated uveal melanoma [PDF]

Purpose: Unfortunately, treatment of patients with uveal melanoma (UM) with metastatic disease is limited. Twenty percent of patients with UM harbor a mutation in the splicing factor gene SF3B1, suggesting that aberrant spliceosome function plays a vital
Brosens, E., Bosch, T.P.P. van den, Leeflang, A.M.C.H.J., Kiliç, E., Drabarek, W., Werken, H.J.G. van de, Riet, J. van, Brands, T., Verdijk, R.M., Paridaens, D., Rotterdam Ocular Melanoma Study Grp, Klein, A. de, Nguyen, J.Q.N.   +12 more
core   +3 more sources

Prognostic impact of SF3B1 mutation and multilineage dysplasia in myelodysplastic syndromes with ring sideroblasts: a Mayo Clinic study of 170 informative cases

Haematologica
The revised 4th edition of the World Health Organization (WHO4R) classification lists myelodysplastic syndromes with ring sideroblasts (MDS-RS) as a separate entity with single lineage (MDS-RS-SLD) or multilineage (MDS-RS-MLD) dysplasia. The more recent
Faiqa Farrukh, Maymona Abdelmagid, Abhishek Mangaonkar, Mrinal Patnaik, Aref Al-Kali, Michelle A. Elliott, Kebede H. Begna, Christopher C. Hook, William J. Hogan, Animesh Pardanani, Mark R. Litzow, Rhett P. Ketterling, Naseema Gangat, Daniel A. Arber, Attilio Orazi, Rong He, Kaaren Reichard, Ayalew Tefferi   +17 more
doaj   +1 more source

The DNA/RNA Helicase SETX Maintains R‐Loop Homeostasis to Promote Chemoresistance in Ovarian Cancer

Cancer Science, EarlyView.
SETX maintains R‐loop homeostasis by resolving excessive R‐loops, thereby promoting tumor initiation and chemoresistance. Deficiency of SETX leads to accumulation of unsolved pathological R‐loops, resulting in irreparable DNA damage and ultimately leading to tumor suppression and chemosensitivity.
Zi‐Wei Hu, Tu‐Nan Xu, Zi‐Ying Wang, Xin Zheng, Duan‐Yong Feng, Xiao‐Min Wang, Er‐Suo Jin, Ming Ren, Xiao‐Min Yang, Xian‐Chao Zhang, Xuan Che, Wei‐Wei Pan, Zha‐Jun Zhan, Shu‐Qun Cheng   +13 more
wiley   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Splicing factor 3b subunit 1 (Sf3b1) haploinsufficient mice display features of low risk Myelodysplastic syndromes with ring sideroblasts [PDF]

, 2014
The presence of somatic mutations in splicing factor 3b subunit 1 (SF3B1) in patients with Myelodysplastic syndromes with ring sideroblasts (MDS-RS) highlights the importance of the RNA-splicing machinery in MDS.
Ali Tabarroki, Reda Mahfouz, Visconte, Valeria, Li Zhang, Mikkael A Sekeres, Barnard, John, Haruhiko Koseki, Hasrouni, Edy, Yvonne Parker, Kyoichi Isono, Mahfouz, Reda, Isono, Kyoichi, Edy Hasrouni, Ramon V Tiu, Saunthararajah, Yogen, Sekeres, Mikkael A, Heesun J Rogers, Zhang, Li, John Barnard, Valeria Visconte, Lindner, Daniel, Tabarroki, Ali, Rogers, Heesun J, Yogen Saunthararajah, Daniel Lindner, Koseki, Haruhiko, Parker, Yvonne, Tiu, Ramon V   +27 more
core   +1 more source