Results 71 to 80 of about 9,852 (179)

Favorable Response to Immunosuppressive Therapy in Severe Aplastic Anemia With Trisomy 8 and BCOR Mutation: Sustained Hematologic Response Despite Evolving Mutational Profile—A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Severe aplastic anemia (SAA) is a serious medical condition that is characterized by its abrupt onset, rapid progression of the disease, and alarmingly high mortality rate, making it a significant concern in the field of hematology. Intensive immunosuppressive therapy (IST) is one of the primary therapeutic options; however, some SAA patients ...
Mengzhu Shen, Yan Wei, Bo Shao, Cao Qin, Xiaofei Jia, Hao Jiang, Jinsong Jia   +6 more
wiley   +1 more source

The Predictive Value of Serum Erythropoietin Levels Measured at Diagnosis in Patients With Myelodysplastic Syndromes

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT Objectives: To study the predictive and prognostic values of serum erythropoietin levels (sEPO) measured at diagnosis in lower‐risk myelodysplastic syndromes. Methods: We analyzed clinical associations and prognosis with sEPO in 672/1610 patients with at least one year of follow‐up data in the prospective EUMDS study.
Dominic Culligan, Adele Taylor, Alexandra Smith, Catherine Cargo, Howard Oster, Argiris Symeonidis, Reinhard Stauder, Saskia Langemeijer, Luca Malcovati, Pierre Fenaux, Jaroslav Čermák, Eva Hellström‐Lindberg, Juliet Mills, Ioannis Kotsianidis, Maud D'Aveni, Corine van Marrewijk, Marlijn Hoeks, Theo de Witte, David Bowen, Moshe Mittelman   +19 more
wiley   +1 more source

Acute Myeloid Leukemia With Florid Plasmacytoid Dendritic Cell Expansion and Aberrant Expression of CD19

International Journal of Laboratory Hematology, EarlyView.
Afshin Shameli, Russell K. Dorer
wiley   +1 more source

Genetic analysis of primary lung interdigitating dendritic cell sarcomas

The Journal of Pathology, Volume 269, Issue 4-5, Page 387-398, August 2026.
Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov, Juliana Faria Filipe, Sylvia Eidenhammer, German Ott, Iris Halbwedl, Karl Kashofer, Helmut Popper   +6 more
wiley   +1 more source

SF3B1 mutation accelerates the development of CLL via activation of the mTOR pathway

JCI Insight
RNA splicing factor SF3B1 is one of the most recurrently mutated genes in chronic lymphocytic leukemia (CLL) and frequently co-occurs with chromosome 13q deletion [del(13q)].
Bo Zhang, Prajish Iyer, Meiling Jin, Elisa Ten Hacken, Zachary J. Cartun, Kevyn L. Hart, Mike Fernandez, Kristen Stevenson, Laura Rassenti, Emanuela M. Ghia, Thomas J. Kipps, Donna Neuberg, Ruben Carrasco, Wing C. Chan, Joo Y. Song, Yu Hu, Catherine J. Wu, Lili Wang   +17 more
doaj   +1 more source

Caspase‐mediated cleavage events hidden by secondary proteolysis during apoptosis

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Caspases are cysteine proteases that cleave specific proteins to control a range of cellular processes including cell death, inflammation, and differentiation. Proteomic approaches, like N‐terminomics, have been central to identifying both cleaved proteins and where they are cleaved.
Fatemeh Fotouhi, Erik Gomez‐Cardona, Jainilkumar Patel, Olivier Julien, Howard Fearnhead   +4 more
wiley   +1 more source

Glomeruloid haemangioma in Erdheim–Chester disease: An atypical skin manifestation associated with elevated vascular endothelial growth factor‐A levels

British Journal of Haematology, Volume 209, Issue 2, Page 755-759, August 2026.
Glomeruloid haemangiomas and extensive angiomas occurred in a small subset of Erdheim–Chester disease patients, all showing markedly elevated vascular endothelial growth factor‐A (VEGF‐A) levels despite the absence of POEMS (polyneuropathy, organomegaly, M‐spike, and skin disease) syndrome.
Jerome Razanamahery, Matthias Papo, Francesco Pegoraro, Felix Blaison, Paul Legendre, Valentin Carado, Martin Caretti, Aubriot Lorton Marie Helene, Jean‐Francois Emile, Augusto Vaglio, Julien Haroche   +10 more
wiley   +1 more source

Identification of UBA7 expression downregulation in myelodysplastic neoplasm with SF3B1 mutations

Scientific Reports
SF3B1 gene mutations are prevalent in myelodysplastic syndrome (MDS) and define a distinct disease subtype. These mutations are associated with dysregulated genes and pathways, offering potential for novel therapeutic approaches.
Sael Alatawi, Othman R. Alzahrani, Fuad A. Alatawi, Ibrahim A. Almazni, Alhomidi Almotiri, Fahad M. Almsned   +5 more
doaj   +1 more source

SF3B1 thermostability as an assay for splicing inhibitor interactions

Journal of Biological Chemistry
The spliceosome protein, SF3B1, is associated with U2 snRNP during early spliceosome assembly for pre-mRNA splicing. Frequent somatic mutations in SF3B1 observed in cancer necessitates the characterization of its role in identifying the branchpoint adenosine of introns.
Angela N. Amorello, Guddeti Chandrashekar Reddy, Bruno Melillo, Benjamin F. Cravatt, Arun K. Ghosh, Melissa S. Jurica   +5 more
openaire   +4 more sources

Inappropriately low hepcidin levels in patients with myelodysplastic syndrome carrying a somatic mutation of SF3B1

Haematologica, 2013
Somatic mutations of the RNA splicing machinery have been recently identified in myelodysplastic syndromes. In particular, a strong association has been found between SF3B1 mutation and refractory anemia with ring sider-oblasts, a condition characterized
Ilaria Ambaglio, Luca Malcovati, Elli Papaemmanuil, Coby M. Laarakkers, Matteo G. Della Porta, Anna Gallì, Matteo C. Da Vià, Elisa Bono, Marta Ubezio, Erica Travaglino, Riccardo Albertini, Peter J. Campbell, Dorine W. Swinkels, Mario Cazzola   +13 more
doaj   +1 more source