Results 81 to 90 of about 12,272 (217)

Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1

Cancer Cell International
Background Chemoresistance is still a significant obstacle to cancer therapy. Overexpression of the splicing factor 3b subunit 1 (SF3B1) and neurogenic locus notch homolog protein 1 (NOTCH1) factors is typically found in chronic lymphocytic leukemia (CLL)
Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi   +15 more
doaj   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Comprehensive analysis of the function, prognosis, and immune infiltration characteristics of SF3B1 mutations in uveal melanoma

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To comprehensively analyze the role, prognosis, and immune infiltration characteristics of splicing factor 3B subunit 1 (SF3B1) mutations in uveal melanoma (UVM).Methods·A total of 20 patients diagnosed with primary UVM who underwent ...
Wang Yiran, Zhang Zhe, Shen Jianfeng
doaj   +1 more source

SF3B1: the lord of the rings in MDS [PDF]

Blood, 2020
Francesc Solé, Laura Palomo
openaire   +2 more sources

Myelodysplasia‐Related Gene Mutation Burden Is Associated With Complete Remission After Induction Therapy in Acute Myeloid Leukemia, Not Otherwise Specified: Reclassification According to the Updated Classifications

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Updated classifications incorporating myelodysplasia‐related (MR) gene mutations reclassify many cases previously diagnosed as acute myeloid leukemia, not otherwise specified (AML, NOS). We evaluated the clinical significance of MR gene mutation burden, defined by mutation number and variant allele frequency (VAF), in AML, NOS ...
Taegeun Lee, Daehyun Chu, Miyoung Kim, Young‐Uk Cho, Sang‐Hyun Hwang, Je‐Hwan Lee, Yunsuk Choi, Eun‐Ji Choi, Ho Joon Im, Hyery Kim, Seongsoo Jang   +10 more
wiley   +1 more source

Allele Loss and Reduced Expression of CYCLOPS Genes is a Characteristic Feature of Chromophobe Renal Cell Carcinoma

Translational Oncology, 2019
Copy-number alterations Yielding Cancer Liabilities Owing to Partial losS (CYCLOPS) genes have been recently identified as the most enriched class of copy-number associated gene dependencies in human cancer.
Riuko Ohashi, Peter Schraml, Aashil Batavia, Silvia Angori, Patrik Simmler, Niels Rupp, Yoichi Ajioka, Esther Oliva, Holger Moch   +8 more
doaj   +1 more source

The PRIME trial: An investigator‐initiated, multicentre, phase II study of the poly(ADP‐ribose) polymerase inhibitor olaparib in isocitrate dehydrogenase (IDH)‐mutated relapsed/refractory acute myeloid leukaemia and myelodysplastic syndromes

British Journal of Haematology, EarlyView.
Rory M. Shallis, Jennifer VanOudenhove, Namrata Chandhok, Justin Watts, Deepa Jeyakumar, Daniel R. Reed, Jan Phillip Bewersdorf, Diane Durecki, Scott Boerner, Richard F. Little, Steven D. Gore, Jing Li, Xun Bao, Li Chen, Sayak Ghatak, Thomas Prebet, Ranjit S. Bindra, Amer M. Zeidan, Stephanie Halene   +18 more
wiley   +1 more source

Genetic alterations of SUGP1 mimic mutant-SF3B1 splice pattern in lung adenocarcinoma and other cancers

, 2020
International audienceGenes involved in 3′-splice site recognition during mRNA splicing constitute an emerging class of oncogenes. SF3B1 is the most frequently mutated splicing factor in cancer, and SF3B1 mutants corrupt branchpoint recognition leading ...
Bellanger, Dorine, Waterfall, Joshua, J, Tarin, Malcy, Roman-Roman, Sergio, Stern, Marc-Henri, Popova, Tatiana, Houy, Alexandre, Cornella, Michele, Alsafadi, Samar, Dayot, Stephane, Wassef, Michel, M., Lehnert, Erik   +11 more
core   +1 more source

Altered RNA Export in SF3B1 Mutants Increases Sensitivity to Nuclear Export Inhibition

, 2023
SF3B1 mutations are the most frequent spliceosomal alterations across cancers, yet no successful therapy exists to target this pathway. Previous findings from a phase 2 clinical trial of the XPO1 inhibitor selinexor in patients with high-risk ...
Chaudhry, Sana, Hariramani, Nidhi, Bilbao, Daniel, Afaghani, Jumana, Beckedorff, Felipe, Rodríguez, Jose Antonio, Bilbao Cortes, Daniel, Wang, Eric, Roberts, Evan R., Montoya, Skye, Affer, Maurizio, Cornista, Alyssa, Totiger, Tulasigeri M, Taylor, Justin   +13 more
core   +1 more source

SF3B1-mutated chronic lymphocytic leukemia shows evidence of NOTCH1 pathway activation including CD20 downregulation

Haematologica, 2020
Chronic lymphocytic leukemia (CLL) is characterized by low CD20 expression, in part explained by an epigenetic-driven downregulation triggered by mutations of the NOTCH1 gene.
Federico Pozzo, Tamara Bittolo, Erika Tissino, Filippo Vit, Elena Vendramini, Luca Laurenti, Giovanni D’Arena, Jacopo Olivieri, Gabriele Pozzato, Francesco Zaja, Annalisa Chiarenza, Francesco Di Raimondo, Antonella Zucchetto, Riccardo Bomben, Francesca Maria Rossi, Giovanni Del Poeta, Michele Dal Bo, Valter Gattei   +17 more
doaj   +1 more source