Results 81 to 90 of about 10,998 (173)

Distinct routes of clonal progression in SF3B1-mutant myelodysplastic syndromes

: Myelodysplastic syndromes (MDS) are clonal stem cell disorders driven by heterogeneous genetic alterations leading to variable clinical course. MDS with splicing factor SF3B1 mutations is a distinct subtype with a favorable outcome.
Luca Malcovati, Laura D. Baquero Galvis, Cristina Picone, Chiara Elena, Anna Gallì, Edie I. Crosse, Sara Pozzi, Elisabetta Molteni, J. Philip Creamer, Sergei Doulatov, Beatrice Ferrari, Robert K. Bradley, Martina Sarchi, Claudia Fiducioso, Courtnee A. Clough, Nelli Aydinyan   +15 more
core   +1 more source

Spliceosomal mutation drives melanoma tumorigenesis via lineage-specific RAS activation. [PDF]

Sci Adv
Jiang R, Xing P, Xie J, Bai G, Zhang Y, Hou P, Luo H, Ma Y, Liu R, Zheng Y, Chen X, Jiang B, Huang J, Zhang Y, Shain AH, Lei M, Judson-Torres RL, Ye J, Liu Z, Zeng H.   +19 more
europepmc   +1 more source

Different <i>SF3B1</i> Mutation Hotspots Show Hematopoietic Lineage-Specific VAF Patterns and Correlate with Distinct Genetic and Prognostic Profiles in Patients with Myeloid Neoplasms. [PDF]

Cancers (Basel)
Calvete O, Mestre J, Zamora L, Chaparro-González L, Ruiz Pérez-Hita L, Torres-Esquius S, Montoro MJ, Xicoy B, Solé F.   +8 more
europepmc   +1 more source

Concurrent <i>SF3B1</i> Mutation and <i>BCR::ABL1</i> Demonstrating a Myelodysplastic Syndrome Phenotype: A Case Report. [PDF]

EJHaem
Brailovski E, Vahedi A, Lisi V, Dmitrienko S, Mercier FE, Lavallée VP, Assouline S.   +6 more
europepmc   +1 more source

Design of SF3B1 subunit modulators of the SF3B spliceosome complex

, 2022
The subject of this dissertation is the search for new therapeutic strategies for pancreatic cancer and aims to implement a Drug Discovery process for the rational design and synthesis of molecules active in the modulation of pathways related to the regulation of pre-mRNA splicing process.
openaire   +3 more sources

Phosphorylation of SF3B1 by CDK11 orchestrates spliceosome activation via SNIP1-dependent RES complex recruitment. [PDF]

Nat Commun
Gajdušková P, Ruiz de Los Mozos I, Hluchý M, Myšková A, Zábrady K, Maník P, Dragišić N, Hanáková K, Potěšil D, Bologna S, Nováček J, Friedel CC, Tripsianes K, Zdráhal Z, Blazek D.   +14 more
europepmc   +1 more source

Spliceosome induction is a druggable dependency of RAS-driven senescence and cancer. [PDF]

Nat Commun
Wagner V, Bousset L, Ascensão-Ferreira M, Sun B, Barragan Avila JE, Kaizeler A, Martins-Silva R, Rahbari M, Fernández-Vaquero M, Haston S, Tinti M, Pombo J, Khadayate S, Roth S, Schürch CM, Martínez-Barbera JP, Bahat A, Wee KB, Morton JP, Malek N, Innes AJ, Vernia S, Barbosa-Morais NL, Gallage S, Heikenwalder M, Gil J.   +25 more
europepmc   +1 more source

Cancer-associated SF3B1 mutation suppresses DNA repair by disrupting the organization of nuclear actin network. [PDF]

Cell Death Dis
Qian R, Zhao Z, Sun X, Xin B, An P, Yang T, Wu N, Hu X, Wan Y.   +8 more
europepmc   +1 more source

Outstanding Questions to Understand and Target Splicing Factor-Mutant Blood Cancers. [PDF]

Blood Cancer Discov
Maron MI, Abdel-Wahab O.
europepmc   +1 more source

Circulating Tumor DNA Monitoring in Patients with Uveal Melanoma Using Mutation-Agnostic Multiplex Drop-Off ddPCR Assays. [PDF]

Anal Chem
Rampanou A, Rodrigues M, Bidard FC, Cassoux N, Matet A, Vincent-Salomon A, Jeannot E, Bieche I, Roman-Roman S, Stern MH, Renault S.   +10 more
europepmc   +1 more source