Results 1 to 10 of about 6,542,890 (150)

Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processing of mRNA subpopulations [PDF]

Nature Communications
Expansion of RNA polymerase III (Pol III) activity in cancer can activate the transcription of typically silent small RNA genes, including snaR-A (small NF90-associated RNA isoform A), a hominid-specific noncoding RNA that promotes cell proliferation ...
Sihang Zhou, Simon Lizarazo, Sandip Chorghade, Leela Mouli, Ruiying Cheng, Rajendra K C, Auinash Kalsotra, Kevin Van Bortle   +7 more
doaj   +2 more sources

GPATCH11 ortholog Sap34 regulates pre-mRNA splicing by interacting with early spliceosomal complexes in Schizosaccharomyces pombe [PDF]

Scientific Reports
Pre-mRNA splicing is an essential step in gene expression regulation. It is mediated by the spliceosome, a large ribonucleoprotein complex that undergoes dynamic structural and compositional rearrangements during each splicing cycle.
Ingrid Cipakova, Laura Olivia Karika, Lucia Hronska, Tomas Selicky, Bogdan Iaparov, Miloslav Karhanek, Lenka Kohutova, Peter Barath, Lubos Cipak   +8 more
doaj   +2 more sources

Nailfold capillary phenotypes distinguish juvenile myositis subtypes and associate with disease activity. [PDF]

Clin Transl Med
Nailfold capillaroscopy is a non‐invasive imaging tool that can aid in the diagnosis and monitoring of juvenile myositis. Branched nailfold capillary morphology is more common in juvenile myositis patients, particularly those positive for TIF1γ+ autoantibodies. Juvenile myositis patients with more active disease demonstrate increased microhaemorrhages,
McClellan N, Chen L, Matossian S, Rynda A, Grant K, Janssen E, Kahlenberg JM, Turnier JL.   +7 more
europepmc   +2 more sources

Phylogenetic analysis and stress response of the plant U2 small nuclear ribonucleoprotein B″ gene family

BMC Genomics, 2022
Background Alternative splicing (AS) is an important channel for gene expression regulation and protein diversification, in addition to a major reason for the considerable differences in the number of genes and proteins in eukaryotes. In plants, U2 small
Cong Gao, Shuai Lu, Rong Zhou, Junjie Ding, Jialiang Fan, Binying Han, Moxian Chen, Baohua Wang, Yunying Cao   +8 more
doaj   +1 more source

Altered mRNA Splicing, Chondrocyte Gene Expression and Abnormal Skeletal Development due to SF3B4 Mutations in Rodriguez Acrofacial Dysostosis. [PDF]

PLoS Genetics, 2016
The acrofacial dysostoses (AFD) are a genetically heterogeneous group of inherited disorders with craniofacial and limb abnormalities. Rodriguez syndrome is a severe, usually perinatal lethal AFD, characterized by severe retrognathia, oligodactyly and ...
Felipe Marques, Jessica Tenney, Ivan Duran, Jorge Martin, Lisette Nevarez, Robert Pogue, Deborah Krakow, Daniel H Cohn, Bing Li   +8 more
doaj   +1 more source

Downregulation of SF3B2 protects CNS neurons in models of multiple sclerosis

Annals of Clinical and Translational Neurology, 2023
Objective Neurodegeneration induced by inflammatory stress in multiple sclerosis (MS) leads to long‐term neurological disabilities that are not amenable to current immunomodulatory therapies.
Ye Eun Jeong, Labchan Rajbhandari, Byung Woo Kim, Arun Venkatesan, Ahmet Hoke   +4 more
doaj   +1 more source

Exomeres and supermeres: Monolithic or diverse?

Journal of Extracellular Biology, 2022
Extracellular vesicles (EVs), including exosomes and microvesicles, are far from being the only RNA‐containing extracellular particles (EPs). Recently, new 35‐nm‐sized EPs were discovered by asymmetric‐flow field‐flow fractionation and termed ‘exomeres’.
Juan Pablo Tosar, Alfonso Cayota, Kenneth Witwer   +2 more
doaj   +1 more source

Malleable ribonucleoprotein machine: protein intrinsic disorder in the Saccharomyces cerevisiae spliceosome [PDF]

PeerJ, 2013
Recent studies revealed that a significant fraction of any given proteome is presented by proteins that do not have unique 3D structures as a whole or in significant parts.
Maria de Lourdes Coelho Ribeiro, Julio Espinosa, Sameen Islam, Osvaldo Martinez, Jayesh Jamnadas Thanki, Stephanie Mazariegos, Tam Nguyen, Maya Larina, Bin Xue, Vladimir N. Uversky   +9 more
doaj   +2 more sources

Evidence that C9ORF72 Dipeptide Repeat Proteins Associate with U2 snRNP to Cause Mis-splicing in ALS/FTD Patients

Cell Reports, 2017
Hexanucleotide repeat expansion in the C9ORF72 gene results in production of dipeptide repeat (DPR) proteins that may disrupt pre-mRNA splicing in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients.
Shanye Yin, Rodrigo Lopez-Gonzalez, Ryan C. Kunz, Jaya Gangopadhyay, Carl Borufka, Steven P. Gygi, Fen-Biao Gao, Robin Reed   +7 more
doaj   +1 more source

Crystal Structure of Prp5p Reveals Interdomain Interactions that Impact Spliceosome Assembly

Cell Reports, 2013
The DEAD-box adenosine triphosphatase (ATPase) Prp5p facilitates U2 small nuclear ribonucleoprotein particle (snRNP) binding to the intron branch site region during spliceosome assembly. We present crystal structures of S.
Zhi-Min Zhang, Fei Yang, Jinru Zhang, Qing Tang, Jie Li, Jing Gu, Jiahai Zhou, Yong-Zhen Xu   +7 more
doaj   +1 more source