Results 31 to 40 of about 5,657 (149)

The U2 small nuclear ribonucleoprotein particle associates with nuclear factors in a pre-mRNA independent reaction.

Journal of Biological Chemistry, 1991
Northern blot analysis of HeLa cell nuclear extract following electrophoresis in nondenaturing gels revealed that a small proportion of U2 small nuclear ribonucleoprotein (snRNP) displays a low mobility, in confirmation of previous reports. This low mobility form of U2 snRNP (termed LMC, for low mobility complex) also formed in vitro when U2 snRNP ...
J, Temsamani, M, Rhoadhouse, T, Pederson
openaire   +2 more sources

Arabidopsis U2AF65 Regulates Flowering Time and the Growth of Pollen Tubes

Frontiers in Plant Science, 2019
During pre-mRNA splicing, U2 small nuclear ribonucleoprotein auxiliary factor 65 (U2AF65) interacts with U2AF35 and splicing factor 1 (SF1), allowing for the recognition of the 3′-splice site by the ternary complex.
Hyo-Young Park, Hee Tae Lee, Jeong Hwan Lee, Jeong-Kook Kim   +3 more
doaj   +1 more source

Autoantibodies to the U2 small nuclear ribonucleoprotein in a patient with scleroderma-polymyositis overlap syndrome.

Journal of Biological Chemistry, 1984
Autoantibodies directed against the U2 small nuclear ribonucleoprotein (snRNP) have been found in the serum of a patient with scleroderma-polymyositis overlap syndrome. This specificity, called anti-(U2)-RNP, is distinct from all previously described autoantibodies, including those that precipitate related snRNPs: anti-Sm antibodies, which react with ...
T, Mimori, M, Hinterberger, I, Pettersson, J A, Steitz   +3 more
openaire   +2 more sources

Fractionation and characterization of human small nuclear ribonucleoproteins containing U1 and U2 RNAs.

Journal of Biological Chemistry, 1983
Human small nuclear ribonucleoproteins (snRNPs) containing U1 and U2 snRNAs have been isolated from cultured cells by nonimmunological methods. The U1 snRNP population remained immunoprecipitable by systemic lupus erythematosis anti-RNP and anti-Sm antibodies throughout fractionation and contained polypeptides of molecular weights corresponding to ...
C S, Kinlaw, B L, Robberson, S M, Berget
openaire   +2 more sources

The U2 small nuclear ribonucleoprotein particle as an autoantigen. Analysis with sera from patients with overlap syndromes. [PDF]

Journal of Clinical Investigation, 1988
We identified eight patients whose sera contained autoantibodies to the U2 small nuclear ribonucleoprotein (snRNP), an RNA protein particle involved in the splicing of newly transcribed messenger RNA. Each of these patients had an overlap syndrome that included features of either systemic lupus erythematosus (SLE), scleroderma, and/or polymyositis.
J, Craft, T, Mimori, T L, Olsen, J A, Hardin   +3 more
openaire   +2 more sources

Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer

Cell Reports
Summary: Triple negative breast cancer (TNBC) is an aggressive type of breast cancer. While most TNBCs are initially sensitive to chemotherapy, a substantial fraction acquires resistance to treatments and progresses to more advanced stages.
Cinzia Caggiano, Valerio Petrera, Miriana Ferri, Marco Pieraccioli, Eleonora Cesari, Alba Di Leone, Martin Alejandro Sanchez, Alessandra Fabi, Riccardo Masetti, Chiara Naro, Claudio Sette   +10 more
doaj   +1 more source

Interactions between Highly Conserved U2 Small Nuclear RNA Structures and Prp5p, Prp9p, Prp11p, and Prp21p Proteins Are Required To Ensure Integrity of the U2 Small Nuclear Ribonucleoprotein in Saccharomyces cerevisiae [PDF]

Molecular and Cellular Biology, 1994
Binding of U2 small nuclear ribonucleoprotein (snRNP) to the pre-mRNA is an early and important step in spliceosome assembly. We searched for evidence of cooperative function between yeast U2 small nuclear RNA (snRNA) and several genetically identified splicing (Prp) proteins required for the first chemical step of splicing, using the phenotype of ...
S E, Wells, M, Ares
openaire   +2 more sources

Association of U2, U4, U5, and U6 small nuclear ribonucleoproteins in a spliceosome-type complex in absence of precursor RNA. [PDF]

Proceedings of the National Academy of Sciences, 1988
Small nuclear ribonucleoprotein particles (snRNPs) associate to form multi-snRNP complexes during splicing of mRNA precursors. A vast majority of the three snRNPs U4, U5, and U6 are present in a nuclear extract in a single complex, while U1 and U2 snRNPs exist as separate particles.
M M, Konarska, P A, Sharp
openaire   +2 more sources

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, EarlyView.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, Volume 13, Issue 44, 7 August 2026.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source