Results 41 to 50 of about 5,657 (149)
U1, U2, and U6 small nuclear ribonucleoproteins (snRNPs) are associated with large nuclear RNP particles containing transcripts of an amplified gene in vivo. [PDF]
Proceedings of the National Academy of Sciences, 1986 Nuclear ribonucleoprotein (RNP) complexes that contain intact transcripts of the amplified gene for CAD, the multifunctional protein that initiates UMP synthesis in Syrian hamster cells, have been released from nuclei of Syrian hamster cells as large particulate structures that sediment at the 200S region in a sucrose gradient.
R, Sperling +3 more
openaire +2 more sources
Journal of Medical Virology, Volume 98, Issue 8, August 2026.ABSTRACT Influenza viruses cause seasonal epidemics, and current vaccines do not fully protect against them. This study focuses on long non‐coding RNAs (lncRNAs), which are RNA molecules that do not code for proteins but play crucial roles in various biological processes. We identified 17 lncRNAs altered by the influenza virus.
Samuel Pushparaj +9 more
wiley +1 more source
Small nuclear ribonucleoprotein (RNP) U2 contains numerous additional proteins and has a bipartite RNP structure under splicing conditions. [PDF]
Molecular and Cellular Biology, 1993 Small nuclear (sn) ribonucleoprotein (RNP) U2 functions in the splicing of mRNA by recognizing the branch site of the unspliced pre-mRNA. When HeLa nuclear splicing extracts are centrifuged on glycerol gradients, U2 snRNPs sediment at either 12S (under high salt concentration conditions) or 17S (under low salt concentration conditions). We isolated the
S E, Behrens +4 more
openaire +2 more sources
RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment
MedComm, Volume 7, Issue 7, July 2026.Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Qiwen Li +3 more
wiley +1 more source
Leucine Periodicity of U2 Small Nuclear Ribonucleoprotein Particle (snRNP) A' Protein Is Implicated in snRNP Assembly via Protein-Protein Interactions [PDF]
Molecular and Cellular Biology, 1991 Recombinant A' protein could be reconstituted into U2 small nuclear ribonucleoprotein particles (snRNPs) upon addition to HeLa cell extracts as determined by coimmunoprecipitation and particle density; however, direct binding to U2 RNA could not be demonstrated except in the presence of the U2 snRNP B" protein.
L D, Fresco, D S, Harper, J D, Keene
openaire +2 more sources
Annals of the New York Academy of Sciences, Volume 1561, Issue 1, July 2026.Ataxin‐1 has been recently implicated in B cell regulation in the context of multiple sclerosis pathology. In this study, we used a multiomics pipeline to profile the B cell transcriptome, epigenome, and proteome in response to encephalitogenic challenges.
Jonathan J. Carver +6 more
wiley +1 more source
Pathogen‐Induced Shifts in Alternative Splicing Shaping Plant Defense
Food and Energy Security, Volume 15, Issue 3, May/June 2026.ABSTRACT Plant immune responses comprise a highly coordinated and dynamic defense network that enables the recognition and containment of diverse microbial pathogens. Alternative splicing (AS), a critical post‐transcriptional regulatory mechanism that generates multiple mRNA isoforms from a single pre‐mRNA precursor, substantially enhances proteomic ...
Zijing Li +3 more
wiley +1 more source
New Phytologist, Volume 250, Issue 2, Page 988-1003, April 2026.Summary Circular RNAs (circRNAs) are single‐stranded, covalently closed RNA molecules that arise from exon back‐splicing. The identification and function investigation of circRNAs have been comprehensively explored in plants, however, the regulatory mechanisms are largely unknown.
Yi Ren +14 more
wiley +1 more source
Solution structures of the first and second RNA‐binding domains of human U2 small nuclear ribonucleoprotein particle auxiliary factor (U2AF65) [PDF]
The EMBO Journal, 1999 The large subunit of the human U2 small nuclear ribonucleoprotein particle auxiliary factor (hU2AF(65)) is an essential RNA-splicing factor required for the recognition of the polypyrimidine tract immediately upstream of the 3' splice site. In the present study, we determined the solution structures of two hU2AF(65) fragments, corresponding to the ...
T, Ito, Y, Muto, M R, Green, S, Yokoyama
openaire +2 more sources
Advanced Science, Volume 13, Issue 17, 23 March 2026.Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao +14 more
wiley +1 more source