Results 41 to 50 of about 333 (143)

Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs

, 2011
Copyright @ 2011 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use ...
E. M. Makarov (7607225), Evgeny M. Makarov, Andrew Bottrill, O. V. Makarova (7607222), Makarov, EM, Bottrill, A, N. Owen (7618997), Owen, N, Olga V. Makarova, Makarova, OV, A. Bottrill (7622258), Nicholas Owen   +11 more
core   +1 more source

Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer

Cell Reports
Summary: Triple negative breast cancer (TNBC) is an aggressive type of breast cancer. While most TNBCs are initially sensitive to chemotherapy, a substantial fraction acquires resistance to treatments and progresses to more advanced stages.
Cinzia Caggiano, Valerio Petrera, Miriana Ferri, Marco Pieraccioli, Eleonora Cesari, Alba Di Leone, Martin Alejandro Sanchez, Alessandra Fabi, Riccardo Masetti, Chiara Naro, Claudio Sette   +10 more
doaj   +1 more source

Interactions between Highly Conserved U2 Small Nuclear RNA Structures and Prp5p, Prp9p, Prp11p, and Prp21p Proteins Are Required To Ensure Integrity of the U2 Small Nuclear Ribonucleoprotein in Saccharomyces cerevisiae [PDF]

Molecular and Cellular Biology, 1994
Binding of U2 small nuclear ribonucleoprotein (snRNP) to the pre-mRNA is an early and important step in spliceosome assembly. We searched for evidence of cooperative function between yeast U2 small nuclear RNA (snRNA) and several genetically identified splicing (Prp) proteins required for the first chemical step of splicing, using the phenotype of ...
S E, Wells, M, Ares
openaire   +2 more sources

Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processing of mRNA subpopulations

Nature Communications
Expansion of RNA polymerase III (Pol III) activity in cancer can activate the transcription of typically silent small RNA genes, including snaR-A (small NF90-associated RNA isoform A), a hominid-specific noncoding RNA that promotes cell proliferation ...
Sihang Zhou, Simon Lizarazo, Sandip Chorghade, Leela Mouli, Ruiying Cheng, Rajendra K C, Auinash Kalsotra, Kevin Van Bortle   +7 more
doaj   +1 more source

Association of U2, U4, U5, and U6 small nuclear ribonucleoproteins in a spliceosome-type complex in absence of precursor RNA. [PDF]

Proceedings of the National Academy of Sciences, 1988
Small nuclear ribonucleoprotein particles (snRNPs) associate to form multi-snRNP complexes during splicing of mRNA precursors. A vast majority of the three snRNPs U4, U5, and U6 are present in a nuclear extract in a single complex, while U1 and U2 snRNPs exist as separate particles.
M M, Konarska, P A, Sharp
openaire   +2 more sources

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment

MedComm, Volume 7, Issue 7, July 2026.
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Qiwen Li, Yating Sun, Shuibin Lin, Quan Yuan   +3 more
wiley   +1 more source

U1, U2, and U6 small nuclear ribonucleoproteins (snRNPs) are associated with large nuclear RNP particles containing transcripts of an amplified gene in vivo. [PDF]

Proceedings of the National Academy of Sciences, 1986
Nuclear ribonucleoprotein (RNP) complexes that contain intact transcripts of the amplified gene for CAD, the multifunctional protein that initiates UMP synthesis in Syrian hamster cells, have been released from nuclei of Syrian hamster cells as large particulate structures that sediment at the 200S region in a sucrose gradient.
R, Sperling, P, Spann, D, Offen, J, Sperling   +3 more
openaire   +2 more sources

Pathogen‐Induced Shifts in Alternative Splicing Shaping Plant Defense

Food and Energy Security, Volume 15, Issue 3, May/June 2026.
ABSTRACT Plant immune responses comprise a highly coordinated and dynamic defense network that enables the recognition and containment of diverse microbial pathogens. Alternative splicing (AS), a critical post‐transcriptional regulatory mechanism that generates multiple mRNA isoforms from a single pre‐mRNA precursor, substantially enhances proteomic ...
Zijing Li, Mojing Zhang, Muhammad Aamir Khan, Muhammad Ali   +3 more
wiley   +1 more source

Structural basis for dual roles of Aar2p in U5 snRNP assembly

, 2013
Yeast U5 small nuclear ribonucleoprotein particle (snRNP) is assembled via a cytoplasmic precursor that contains the U5-specific Prp8 protein but lacks the U5-specific Brr2 helicase.
Jovin, S.M., Beggs, J., Wahl, M., Cristao, V., Heroven, A., Cristão, V.F., Beggs, J.D., Santos, K., Santos, K.F., Holton, N., Weber, G., Mozaffari-Jovin, S., Heroven, A.C., Wahl, M.C., Lührmann, R.   +14 more
core   +1 more source

In vivo analysis of NHPX reveals a novel nucleolar localization pathway involving a transient accumulation in splicing speckles [PDF]

, 2002
The NHPX protein is a nucleolar factor that binds directly to a conserved RNA target sequence found in nucleolar box C/D snoRNAs and in U4 snRNA. Using enhanced yellow fluorescent protein (EYFP)– and enhanced cyan fluorescent protein–NHPX fusions, we ...
Leung, Anthony K. L., Angus I. Lamond, Anthony K.L. Leung, Lamond, Angus I.; id_orcid   +3 more
core   +1 more source