Results 1 to 10 of about 15,077 (245)
New insights into trypanosomatid U5 small nuclear ribonucleoproteins [PDF]
Memorias do Instituto Oswaldo Cruz, 2011 Several protozoan parasites exist in the Trypanosomatidae family, including various agents of human diseases. Multiple lines of evidence suggest that important differences are present between the translational and mRNA processing (trans splicing) systems
Marco Túlio A da Silva +8 more
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Insights into the function and structure of the R2TP (RUVBL1-RUVBL2-RPAP3-PIH1D1) chaperone complex [PDF]
Cell Stress & ChaperonesThe R2TP chaperone complex comprises two AAA+ proteins, RUVBL1 and RUVBL2, along with RPAP3 and PIH1D1. R2TP functions in concert with other chaperones, such as HSP90 and HSP70, to facilitate the assembly of macromolecular complexes integral to the ...
Maryama Mohamed +2 more
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SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights [PDF]
Annals of Clinical and Translational NeurologyObjective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far,
Nuria Muelas +18 more
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Spliceosomal snRNA Epitranscriptomics
Frontiers in Genetics, 2021 Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cell ...
Pedro Morais, Hironori Adachi, Yi-Tao Yu
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Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder
Nature Communications, 2021 GEMIN5, an RNA-binding protein, is required for formation of small nuclear ribonucleoproteins. Here, the authors identify loss of function mutations in GEMIN5 that are associated with a human neurodevelopmental disorder.
Sukhleen Kour +69 more
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Non-Coding RNA, 2023 Traditionally, small molecule-based drug discovery has mainly focused on proteins as the drug target. Opening RNA as an additional target space for small molecules offers the possibility to therapeutically modulate disease-driving non-coding RNA targets ...
Nina Zablowsky +8 more
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Cajal body proteins differentially affect the processing of box C/D scaRNPs. [PDF]
PLoS ONE, 2015 Small nuclear ribonucleoproteins (snRNPs), which are required for pre-mRNA splicing, contain extensively modified snRNA. Small Cajal body-specific ribonucleoproteins (scaRNPs) mediate these modifications.
Isioma I Enwerem +3 more
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The assembly of a spliceosomal small nuclear ribonucleoprotein particle [PDF]
Nucleic Acids Research, 2008 The U1, U2, U4, U5 and U6 small nuclear ribonucleoprotein particles (snRNPs) are essential elements of the spliceosome, the enzyme that catalyzes the excision of introns and the ligation of exons to form a mature mRNA. Since their discovery over a quarter century ago, the structure, assembly and function of spliceosomal snRNPs have been extensively ...
Patel, Snehal Bhikhu, Bellini, Michel
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Principles and correction of 5’-splice site selection
RNA Biology, 2022 In Eukarya, immature mRNA transcripts (pre-mRNA) often contain coding sequences, or exons, interleaved by non-coding sequences, or introns. Introns are removed upon splicing, and further regulation of the retained exons leads to alternatively spliced ...
Florian Malard +2 more
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PHF5A promotes colorectal cancerprogression by alternative splicing of TEAD2
Molecular Therapy: Nucleic Acids, 2021 Dysregulated alternative splicing (AS) plays critical roles in driving cancer progression, and the underlying mechanisms remain largely unknown. Here, we demonstrated that PHF5A, a component of U2 small nuclear ribonucleoproteins, was frequently ...
Yue Chang +21 more
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