Results 11 to 20 of about 24,694 (278)

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights [PDF]

Annals of Clinical and Translational Neurology
Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far,
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
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Independent deposition of heterogeneous nuclear ribonucleoproteins and small nuclear ribonucleoprotein particles at sites of transcription. [PDF]

Proceedings of the National Academy of Sciences, 1992
The major nuclear ribonucleoproteins (RNPs) involved in pre-mRNA processing are classified in broad terms either as small nuclear RNPs (snRNPs), which are major participants in the splicing reaction, or heterogeneous nuclear RNPs (hnRNPs), which traditionally have been thought to function in general pre-mRNA packaging.
S A, Amero, G, Raychaudhuri, C L, Cass, W J, van Venrooij, W J, Habets, A R, Krainer, A L, Beyer   +6 more
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Reconstitution of the U1 small nuclear ribonucleoprotein particle. [PDF]

Molecular and Cellular Biology, 1987
Although the U1 small nuclear ribonucleoprotein particle (snRNP) was the first mRNA-splicing cofactor to be identified, the manner in which it functions in splicing is not precisely understood. Among the information required to understand how U1 snRNP participates in splicing, it will be necessary to know its structure.
J R, Patton, R J, Patterson, T, Pederson
openaire   +3 more sources

High-sensitivity profiling of SARS-CoV-2 noncoding region–host protein interactome reveals the potential regulatory role of negative-sense viral RNA

mSystems, 2023
A deep understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–host interactions is crucial to developing effective therapeutics and addressing the threat of emerging coronaviruses.
Liuyiqi Jiang, Mu Xiao, Qing-Qing Liao, Luqian Zheng, Chunyan Li, Yuemei Liu, Bing Yang, Aiming Ren, Chao Jiang, Xin-Hua Feng   +9 more
doaj   +1 more source

Nuclear organization of splicing small nuclear ribonucleoproteins in adenovirus-infected cells [PDF]

Journal of Virology, 1993
We have studied the effect of adenovirus infection on the nuclear organization of splicing small nuclear ribonucleoproteins (snRNPs) in HeLa cells. In uninfected HeLa cells, snRNPs are widespread throughout the nucleoplasm but also are concentrated in specific nuclear structures, including coiled bodies, interchromatin granules, and perichromatin ...
Bridge, E., Carmo-Fonseca, M., Lamond, A., Pettersson, U.   +3 more
openaire   +2 more sources

U1RNP/lncRNA/Transcription Cycle Axis Promotes Tumorigenesis of Hepatocellular Carcinoma

Diagnostics, 2022
As a component of the spliceosome, U1 small nuclear ribonucleoproteins (U1RNPs) play critical roles in RNA splicing, and recent studies have shown that U1RNPs could recruit long non-coding RNAs (lncRNAs) to chromatin which are involved in cancer ...
Shun Li, Shuaiyin Zhang, Mingle Huang, Huanjing Hu, Yubin Xie   +4 more
doaj   +1 more source

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP [PDF]

, 2013
Through controlling the nuclear level of active positive transcription elongation factor b (P-TEFb), the 7SK small nuclear RNA (snRNA) functions as a key regulator of RNA polymerase II transcription.
Bayfield, Bhattacharya, Biewenga, Blazek, Chambers, Cheng, de Almeida, Diribarne, Egloff, Goodall, Gupta, Gupta, Jeronimo, Jobert, Kiss, Kiss, Kiss, L. Muniz, Markert, Michels, Muniz, Nguyen, O'Keeffe, Peterlin, Price, S. Egloff, Shimba, Shimba, Shumyatsky, Shumyatsky, Singh, Singh, Singh, T. Kiss, Takahasi, Van Herreweghe, Wada, Wassarman, Yamaguchi, Yang, Yik, Yik, Zhou, Zhou   +43 more
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Insights into the U1 small nuclear ribonucleoprotein complex superfamily [PDF]

WIREs RNA, 2014
The 164 bp U1 small nuclear (sn) RNA is one of the most abundant noncoding (nc) RNA in human cells, estimated to be in the region of 106 copies/cell. Although best known for its role in pre‐messenger RNA (mRNA) splicing events, research over the past 20 years has revealed diverse functions of this ncRNA in mammalian cell types.
Guiro, J, O'Reilly, D
openaire   +3 more sources

Crystal Structures of Influenza A Virus Matrix Protein M1: Variations on a Theme [PDF]

, 2014
Matrix protein 1 (M1) of the influenza A virus plays multiple roles in virion assembly and infection. Interest in the pH dependence of M1\u27s multiple functions led us to study the effect of subtle pH changes on M1 structure, resulting in the ...
Desai, Umesh R., Mosier, Philip D., Musayev, Faik N., Safo, Martin K., Xie, Hang, Zhou, Qibing   +5 more
core   +3 more sources

Functional rescue of dystrophin deficiency in mice caused by frameshift mutations using Campylobacter jejuni Cas9 [PDF]

, 2018
Duchenne muscular dystrophy (DMD) is a fatal, X-linked muscle wasting disease caused by mutations in the DMD gene. In 51% of DMD cases, a reading frame is disrupted because of deletion of several exons.
Cappellari, O, Cho, H-Y, Dickson, G, Kim, D, Kim, E, Kim, J-S, Koo, T, Lu-Nguyen, N B, Malerba, A, Popplewell, L   +9 more
core   +2 more sources