Results 31 to 40 of about 24,694 (278)

Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication. [PDF]

, 2013
Myxoma virus (MYXV)-encoded protein M029 is a member of the poxvirus E3 family of dsRNA-binding proteins that antagonize the cellular interferon signaling pathways.
Chan, Winnie M, Liu, Jia, McFadden, Grant, Rahman, Masmudur M, Rothenburg, Stefan   +4 more
core   +1 more source

The Cajal body and the nucleolus : “in a relationship” or “it's complicated”? [PDF]

, 2016
From their initial identification as 'nucleolar accessory bodies' more than a century ago, the relationship between Cajal bodies and nucleoli has been a subject of interest and controversy.
Sleeman, Judith E., Trinkle-Mulcahy, Laura   +1 more
core   +1 more source

In vitro RNase and nucleic acid binding activities implicate coilin in U snRNA processing.

PLoS ONE, 2012
Coilin is known as the marker protein for Cajal bodies (CBs), subnuclear domains important for the biogenesis of small nuclear ribonucleoproteins (snRNPs) which function in pre-mRNA splicing.
Hanna J Broome, Michael D Hebert
doaj   +1 more source

The Small-Molecule Flunarizine in Spinal Muscular Atrophy Patient Fibroblasts Impacts on the Gemin Components of the SMN Complex and TDP43, an RNA-Binding Protein Relevant to Motor Neuron Diseases

Frontiers in Molecular Biosciences, 2020
The motor neurodegenerative disease spinal muscular atrophy (SMA) is caused by alterations of the survival motor neuron 1 (SMN1) gene involved in RNA metabolism.
Delphine Sapaly, Perrine Delers, Jennifer Coridon, Badih Salman, Franck Letourneur, Florent Dumont, Suzie Lefebvre   +6 more
doaj   +1 more source

WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies. [PDF]

PLoS Biology, 2010
The WRAP53 gene gives rise to a p53 antisense transcript that regulates p53. This gene also encodes a protein that directs small Cajal body-specific RNAs to Cajal bodies.
Salah Mahmoudi, Sofia Henriksson, Irene Weibrecht, Stephen Smith, Ola Söderberg, Staffan Strömblad, Klas G Wiman, Marianne Farnebo   +7 more
doaj   +1 more source

Host Factors interacting with the Pestivirus N terminal protease, Npro are Components of the Ribonucleoprotein Complex [PDF]

, 2014
The viral N-terminal protease N(pro) of pestiviruses counteracts cellular antiviral defenses through inhibition of IRF3. Here we used mass spectrometry to identify a new role for N(pro) through its interaction with over 55 associated proteins, mainly ...
A. Donaszi-Ivanov, Anderson, Aratani, Ariumi, Barsnes, Bauhofer, Beckham, Belsham, Bensaude, Borghese, Chatel-Chaix, Chatel-Chaixa, Costa-Mattioli, Cox, Dixit, Doceul, Eisinger-Mathason, Ettema, Fiebach, Fullam, G. Saalbach, Garcia, Gilks, Gorchakov, Haasnoot, Isken, Jefferson, Johns, Kato, Kok, La Rocca, Lawrence, Leung, Li, Liu, Lloyd, M. Jefferson, Meyers, Müller-McNicoll, Netherton, Onishi, P. P. Powell, Panas, Paranjape, Peterhans, Pichlmair, Piotrowska, Robb, Rümenapf, S. Pollen, Sadler, Saunders, Schröder, Szymanski, T. Dalmay, Taylor, Tetsuka, Tetsuka, Tratschin, White, White, Zhang, Zögg   +62 more
core   +1 more source

Coilin association with Box C/D scaRNA suggests a direct role for the Cajal body marker protein in scaRNP biogenesis

Biology Open, 2014
Spliceosomal small nuclear ribonucleoproteins (snRNPs) are enriched in the Cajal body (CB). Guide RNAs, known as small Cajal body-specific RNAs (scaRNAs), direct modification of the small nuclear RNA (snRNA) component of the snRNP.
Isioma I. Enwerem, Venkatramreddy Velma, Hanna J. Broome, Marija Kuna, Rowshan A. Begum, Michael D. Hebert   +5 more
doaj   +1 more source

Regulation of RNA Splicing: Aberrant Splicing Regulation and Therapeutic Targets in Cancer

Cells, 2021
RNA splicing is a critical step in the maturation of precursor mRNA (pre-mRNA) by removing introns and exons. The combination of inclusion and exclusion of introns and exons in pre-mRNA can generate vast diversity in mature mRNA from a limited number of ...
Koji Kitamura, Keisuke Nimura
doaj   +1 more source

Structural basis for dual roles of Aar2p in U5 snRNP assembly [PDF]

, 2013
Yeast U5 small nuclear ribonucleoprotein particle (snRNP) is assembled via a cytoplasmic precursor that contains the U5-specific Prp8 protein but lacks the U5-specific Brr2 helicase.
Beggs, J.D., Cristão, V.F., Heroven, A.C., Holton, N., Jovin, S.M., Lührmann, R., Santos, K.F., Wahl, M.C., Weber, G.   +8 more
core   +1 more source

Regulation of Pre-mRNA Splicing: Indispensable Role of Post-Translational Modifications of Splicing Factors

Life, 2023
Pre-mRNA splicing is a process used by eukaryotic cells to generate messenger RNAs that can be translated into proteins. During splicing, the non-coding regions of the RNAs (introns) are removed from pre-mRNAs and the coding regions (exons) are joined ...
Miroslava Kretova, Tomas Selicky, Ingrid Cipakova, Lubos Cipak   +3 more
doaj   +1 more source