Results 51 to 60 of about 333 (143)

Circular RNA Vv‐circCOR27 modulates thermotolerance through attenuating VvHSP90.2b‐VvHsfA7a interaction in grapevine

New Phytologist, Volume 250, Issue 2, Page 988-1003, April 2026.
Summary Circular RNAs (circRNAs) are single‐stranded, covalently closed RNA molecules that arise from exon back‐splicing. The identification and function investigation of circRNAs have been comprehensively explored in plants, however, the regulatory mechanisms are largely unknown.
Yi Ren, Yuanyuan Xu, Moyang Liu, Lipeng Zhang, Yue Song, Junpeng Li, Jingjing Liu, Dongying Fan, Zhen Zhang, Juan He, Jiuyun Wu, Qian Zha, Zhen Gao, Zheng'an Yang, Chao Ma   +14 more
wiley   +1 more source

Leucine Periodicity of U2 Small Nuclear Ribonucleoprotein Particle (snRNP) A' Protein Is Implicated in snRNP Assembly via Protein-Protein Interactions [PDF]

Molecular and Cellular Biology, 1991
Recombinant A' protein could be reconstituted into U2 small nuclear ribonucleoprotein particles (snRNPs) upon addition to HeLa cell extracts as determined by coimmunoprecipitation and particle density; however, direct binding to U2 RNA could not be demonstrated except in the presence of the U2 snRNP B" protein.
L D, Fresco, D S, Harper, J D, Keene
openaire   +2 more sources

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. [PDF]

, 1997
Published ...
Cáceres, J. F., Misteli, T, Spector, DL, Javier F. Cáceres, Cáceres, JF, Krainer, AR, Screaton, G. R., Spector, D. L., Tom Misteli, Adrian R. Krainer, Krainer, A. R., Gavin R. Screaton, Screaton, GR, David L. Spector, Misteli, T.   +14 more
core   +1 more source

Molecular Responses to Climate Change: How Warming and Acidification Reshape the Proteome and Phosphoproteome of the Endangered Mira Chub

Ecology and Evolution, Volume 16, Issue 3, March 2026.
ABSTRACT Global environmental change affects organisms, including their physiology. In freshwater ecosystems, where migration is limited, populations often rely on phenotypic plasticity to respond. While transcriptomics has been widely used to study stress responses at the molecular level, less is known about the proteome, which reflects post ...
João M. Moreno, Jonas Grossmann, Laura Kunz, Antje Dittmann, Vitor C. Sousa, Romana Santos   +5 more
wiley   +1 more source

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

Structural investigation of human U6 snRNA recognition by spliceosomal recycling factor SART3 RNA recognition motifs

The FEBS Journal, Volume 293, Issue 5, Page 1323-1340, March 2026.
Human SART3 has two RRM domains to engage with U6 snRNA for spliceosome recycling. This study reports solution structures of SART3 RRM domains and investigates the interaction between RRM and U6 snRNA. SART3 binds to the asymmetric bulge of U6 snRNA as a dimer via conserved positively charged surfaces.
Iktae Kim, Kyeong‐Mi Bang, So Young An, Changkon Park, Ji‐Yeon Shin, Youngim Kim, Hyun Kyu Song, Jeong‐Yong Suh, Nak‐Kyoon Kim   +8 more
wiley   +1 more source

tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes

, 2006
Infection of non-dividing cells is a biological property of HIV-1 crucial for virus transmission and AIDS pathogenesis. This property depends on nuclear import of the intracellular reverse transcription and pre-integration complexes (RTCs/PICs).
Zaitseva Lyubov, Fassati Ariberto, Myers Richard, Myers, R, Lyubov Zaitseva, Ariberto Fassati, Fassati, A, Richard Myers, Zaitseva, L   +8 more
core   +1 more source

Solution structures of the first and second RNA-binding domains of human U2 small nuclear ribonucleoprotein particle auxiliary factor (U2AF65) [PDF]

The EMBO Journal, 1999
The large subunit of the human U2 small nuclear ribonucleoprotein particle auxiliary factor (hU2AF(65)) is an essential RNA-splicing factor required for the recognition of the polypyrimidine tract immediately upstream of the 3' splice site. In the present study, we determined the solution structures of two hU2AF(65) fragments, corresponding to the ...
T, Ito, Y, Muto, M R, Green, S, Yokoyama
openaire   +2 more sources

Gezielte Modulation des spliceosomalen Proteins USP39 durch allosterische Liganden und PROTAC‐induzierte Degradation

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Proteolysis‐targeting Chimeras (PROTACs) ermöglichen die gezielte Degradation bislang als „undruggable“ geltende Proteine über das zelluläre Ubiquitin–Proteasom‐System. In dieser Studie identifizieren Schäfer et al. thiazolbasierte niedermolekulare Liganden, die allosterisch an die Zinkfinger‐Domäne der Ubiquitin‐spezifischen Protease 39 (USP39) binden
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source