Cell division promotes efficient retrotransposition in a stable L1 reporter cell line [PDF]
, 2013 Background: Long interspersed element type one (L1) actively modifies the human genome by inserting new copies of itself. This process, termed retrotransposition, requires the formation of an L1 ribonucleoprotein (RNP) complex, which must enter the ...
Ivics, Z. +17 more
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Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA [PDF]
, 2009 U1-snRNA is an integral part of the U1 ribonucleoprotein pivotal for pre-mRNA splicing. Toll-like receptor (TLR) signaling has recently been associated with immunoregulatory capacities of U1-snRNA.
Pfeilschifter, Josef (Prof. Dr.) +3 more
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Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome [PDF]
, 2002 Major structural changes occur in the spliceosome during its activation just before catalyzing the splicing of pre-messenger RNAs (pre-mRNAs). Whereas changes in small nuclear RNA ( snRNA) conformation are well documented, little is known about ...
Makarova, O. +6 more
core +1 more source
A human U2 RNA mutant stalled in 3' end processing is impaired in nuclear import
, 2009 The biosynthesis of U1, U2, U4 and U5 spliceosomal small nuclear RNAs (snRNAs) involves the nuclear export of precursor molecules extended at their 3' ends, followed by a cytoplasmic phase during which the pre-snRNAs assemble into ribonucleoprotein ...
Pederson, Thoru, Huang, Qian
core
Nuclear RNA-binding proteins meet cytoplasmic viruses [PDF]
Cytoplasmic viruses interact intricately with the nuclear pore complex and nuclear import/export machineries, affecting nuclear-cytoplasmic trafficking.
Castello, Alfredo, Kamel, Wael
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Higher order nuclear organization: three-dimensional distribution of small nuclear ribonucleoprotein particles [PDF]
, 1990 The structural and functional organization of the cell nucleus has been investigated using three-dimensional reconstruction, immunoelectron microscopy, and high-resolution in situ autoradiography.
Spector, D. L.
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Modulation of nuclear localization of the influenza virus nucleoprotein through interaction with actin filaments [PDF]
, 1999 The influenza virus genome is transcribed in the nuclei of infected cells but assembled into progeny virions in the cytoplasm. This is reflected in the cellular distribution of the virus nucleoprotein (NP), a protein which encapsidates genomic RNA to ...
Pope, Brian +5 more
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Structure-function analysis of the U2 snRNP-associated splicing factor SF3a
, 2005 Human splicing factor SF3a is a part of the 17 S U2 snRNP (small nuclear ribonucleoprotein), which interacts with the pre-mRNA branch site early during spliceosome formation.
Nesic, Dobrila +5 more
core +1 more source
, 2015 Purpose: Identification and functional characterisation of a novel candidate gene for autosomal dominant retinitis pigmentosa (adRP). Methods: Five affected and five unaffected individuals of a Belgian adRP family in which known adRP loci were excluded,
Van Cauwenbergh, Caroline +9 more
core
, 1993 In the assembly of a prespliceosome, U2 small nuclear ribonucleoprotein (snRNP) functions in pre-messenger RNA (mRNA) splicing together with splicing factors (SFs) 3a, SF3b, and several other proteins.
Krämer A +4 more
core +1 more source