Results 91 to 100 of about 333 (143)

Additional file 1 of Phylogenetic analysis and stress response of the plant U2 small nuclear ribonucleoprotein B″ gene family

, 2022
Additional file 1: Fig. S1. Formation of mature 17S U2 snRNP. The upper one is12S core particle, the middle one is 15S pre-mature particle, and the lower oneis 17S functional maturity particle. Continuous thin black lines represent U2 snRNA. Fig. S2. The design process of the whole article. Fig. S3.
Gao, Cong, Lu, Shuai, Zhou, Rong, Ding, Junjie, Fan, Jialiang, Han, Binying, Chen, Moxian, Wang, Baohua, Cao, Yunying   +8 more
openaire   +1 more source

Structure-function analysis of the U2 snRNP-associated splicing factor SF3a

, 2005
Human splicing factor SF3a is a part of the 17 S U2 snRNP (small nuclear ribonucleoprotein), which interacts with the pre-mRNA branch site early during spliceosome formation.
Nesic, Dobrila, Huang, Ching-Jung, Mulhaupt, Flore, Ferfoglia, Fabio, Kraemer, Angela, Tanackovic Abbas-Terki, Goranka   +5 more
core   +1 more source

3 '-processing of yeast tRNA(Trp) precedes 5 '-processing [PDF]

, 2003
Previous analyses of eukaryotic pre-tRNAs processing have reported that 5'-cleavage by RNase P precedes 3'-maturation. Here we report that in contrast to all other yeast tRNAs analyzed to date, tRNA(Trp) undergoes 3'-maturation prior to 5'-cleavage ...
Tollervey, D, Kufel, J
core   +1 more source

Mutations in the U5 snRNA result in altered splicing of subsets of pre-mRNAs and reduced stability of Prp8

, 2009
The U5 snRNA loop 1 aligns the 5' and 3' exons for ligation during the second step of pre-mRNA splicing. U5 is intimately associated with Prp8, which mediates pre-mRNA repositioning within the catalytic core of the spliceosome and interacts directly with
David Barrass, J., Kershaw, Christopher J., O'Keefe, Raymond T., Barrass, J. David, Beggs, Jean D., O'Keefe, Raymond T.; id_orcid   +5 more
core   +1 more source

Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles [PDF]

RNA is a central molecule for viruses; however, the interactions that viral RNA (vRNA) establishes with the host cell is only starting to be elucidated.
Demyanenko, Yana, Orton, Richard J., Castello, Alfredo, Mohammed, Shabaz, Davis, Ilan, Järvelin, Aino I, Järvelin, Aino, de Laurent, Zaydah R., Hannan, Maximilian, Moore, Samantha, Orton, Richard J, Kamel, Wael, Noerenberg, Marko, Merits, Andres, Ruscica, Vincenzo, Madhusudhan, Meghana, de Laurent, Zaydah R, Kitano, Eduardo, Garcia-Moreno, Manuel, Embarc-Buh, Azman, Iselin, Louisa   +20 more
core   +1 more source

A human U2 RNA mutant stalled in 3' end processing is impaired in nuclear import

, 2009
The biosynthesis of U1, U2, U4 and U5 spliceosomal small nuclear RNAs (snRNAs) involves the nuclear export of precursor molecules extended at their 3' ends, followed by a cytoplasmic phase during which the pre-snRNAs assemble into ribonucleoprotein ...
Pederson, Thoru, Huang, Qian
core  

Mutations in the small subunit of the Drosophila U2AF splicing factor cause lethality and developmental defects [PDF]

, 1996
The essential eukaryotic pre-mRNA splicing factor U2AF (U2 small nuclear ribonucleoprotein auxiliary factor) is required to specify the 3' splice site at an early step in spliceosome assembly.
Breger, K.S. (Kevin), Kanaar, R. (Roland), Rudner, D.Z. (David), Rio, D.C. (Donald)   +3 more
core   +1 more source

The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region

, 2011
Duplex formation between the branch point-binding region (BBR) of U2 snRNA and the branch point sequence (BPS) in the intron is essential for splicing.
Eric G. Folco, Robin Reed, Kaitlyn E. Coil   +2 more
core   +1 more source

Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA

, 2009
U1-snRNA is an integral part of the U1 ribonucleoprotein pivotal for pre-mRNA splicing. Toll-like receptor (TLR) signaling has recently been associated with immunoregulatory capacities of U1-snRNA.
Pfeilschifter, Josef (Prof. Dr.), Sadik, Christian David, Bachmann, Malte, Mühl, Heiko   +3 more
core   +1 more source

Differential 3′ splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP

, 2009
Spinal Muscular atrophy is a prevalent genetic disease caused by mutation of the SMN1 gene, which encodes the SMN protein involved in assembly of small nuclear ribonucleoprotein (snRNP) complexes.
Bonnal, S., De Araújo, M. M., Valcárcel, J., Krainer, A. R., Hastings, M. L.   +4 more
core   +1 more source